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@article{1774323,
author = {Kayser, S. and Hills, R. K. and Langova, R. and Kramer, M. and Guijarro, F. and Šustková, Zuzana and Estey, E. H. and Shaw, C. M. and Ráčil, Zdeněk and Mayer, Jiří and Zak, Pavel and Baer, M. R. and Brunner, A. M. and Szotkowski, T. and Cetkovsky, Petr and Grimwade, D. and Walter, R. B. and Burnett, A. K. and Ho, A. D. and Ehninger, G. and MullerandTidow, C. and Platzbecker, U. and Thiede, C. and Rollig, C. and Schulz, A. and Warsow, G. and Brors, B. and Esteve, J. and Russell, N. H. and Schlenk, R. F. and Levis, M. J.},
article_location = {England},
article_number = {5},
doi = {http://dx.doi.org/10.1111/bjh.17336},
keywords = {acute myeloid leukaemia; t(8;16)(p11;p13)/MYST3-CREBBP; whole-genome sequencing; allogeneic haematopoietic cell transplantation; outcome},
language = {eng},
issn = {0007-1048},
journal = {British journal of haematology},
title = {Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study},
url = {https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17336},
volume = {192},
year = {2021}
}
TY - JOUR
ID - 1774323
AU - Kayser, S. - Hills, R. K. - Langova, R. - Kramer, M. - Guijarro, F. - Šustková, Zuzana - Estey, E. H. - Shaw, C. M. - Ráčil, Zdeněk - Mayer, Jiří - Zak, Pavel - Baer, M. R. - Brunner, A. M. - Szotkowski, T. - Cetkovsky, Petr - Grimwade, D. - Walter, R. B. - Burnett, A. K. - Ho, A. D. - Ehninger, G. - Muller-Tidow, C. - Platzbecker, U. - Thiede, C. - Rollig, C. - Schulz, A. - Warsow, G. - Brors, B. - Esteve, J. - Russell, N. H. - Schlenk, R. F. - Levis, M. J.
PY - 2021
TI - Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study
JF - British journal of haematology
VL - 192
IS - 5
SP - 832-842
EP - 832-842
PB - Wiley-Blackwell
SN - 00071048
KW - acute myeloid leukaemia
KW - t(8;16)(p11;p13)/MYST3-CREBBP
KW - whole-genome sequencing
KW - allogeneic haematopoietic cell transplantation
KW - outcome
UR - https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17336
N2 - In acute myeloid leukaemia (AML) t(8;16)(p11;p13)/MYST3-CREBBP is a very rare abnormality. Previous small series suggested poor outcome. We report on 59 patients with t(8;16) within an international, collaborative study. Median age was 52 (range: 16-75) years. AML was de novo in 58%, therapy-related (t-AML) in 37% and secondary after myelodysplastic syndrome (s-AML) in 5%. Cytogenetics revealed a complex karyotype in 43%. Besides MYST3-CREBBP, whole-genome sequencing on a subset of 10 patients revealed recurrent mutations in ASXL1, BRD3, FLT3, MLH1, POLG, TP53, SAMD4B (n = 3, each), EYS, KRTAP9-1 SPTBN5 (n = 4, each), RUNX1 and TET2 (n = 2, each). Complete remission after intensive chemotherapy was achieved in 84%. Median follow-up was 5 center dot 48 years; five-year survival rate was 17%. Patients with s-/t-AML (P = 0 center dot 01) and those with complex karyotype (P = 0 center dot 04) had an inferior prognosis. Allogeneic haematopoietic cell transplantation (allo-HCT) was performed in 21 (36%) patients, including 15 in first complete remission (CR1). Allo-HCT in CR1 significantly improved survival (P = 0 center dot 04); multivariable analysis revealed that allo-HCT in CR1 was effective in de novo AML but not in patients with s-AML/t-AML and less in patients exhibiting a complex karyotype. In summary, outcomes of patients with t(8;16) are dismal with chemotherapy, and may be substantially improved with allo-HCT performed in CR1.
ER -
KAYSER, S., R. K. HILLS, R. LANGOVA, M. KRAMER, F. GUIJARRO, Zuzana ŠUSTKOVÁ, E. H. ESTEY, C. M. SHAW, Zdeněk RÁČIL, Jiří MAYER, Pavel ZAK, M. R. BAER, A. M. BRUNNER, T. SZOTKOWSKI, Petr CETKOVSKY, D. GRIMWADE, R. B. WALTER, A. K. BURNETT, A. D. HO, G. EHNINGER, C. MULLER-TIDOW, U. PLATZBECKER, C. THIEDE, C. ROLLIG, A. SCHULZ, G. WARSOW, B. BRORS, J. ESTEVE, N. H. RUSSELL, R. F. SCHLENK a M. J. LEVIS. Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study. \textit{British journal of haematology}. England: Wiley-Blackwell, 2021, roč.~192, č.~5, s.~832-842. ISSN~0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.17336.
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