CCR5 Delta 32 Deletion as a Protective Factor in Czech
First-Wave COVID-19 Subjects

J 2021

CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects

HUBACEK, Jaroslav A., Ladislav DUŠEK, Ondřej MÁJEK, Vaclav ADAMEK, Tereza CERVINKOVA et. al.

Základní údaje

Originální název

CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects

Autoři

HUBACEK, Jaroslav A. (203 Česká republika, garant), Ladislav DUŠEK (203 Česká republika, domácí), Ondřej MÁJEK (203 Česká republika, domácí), Vaclav ADAMEK (203 Česká republika), Tereza CERVINKOVA (203 Česká republika), Dana DLOUHA (203 Česká republika), Jozef PAVEL (203 Česká republika) a Vera ADAMKOVA (203 Česká republika)

Vydání

Physiological research, Praha, Fyziologický ústav AV ČR, 2021, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.139

Kód RIV

RIV/00216224:14110/21:00121769

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.33549/physiolres.934647

UT WoS

000631146600011

Klíčová slova anglicky

COVID-19; CCR5; Polymorphism; Deletion; Delta 32

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 6. 2021 07:49, Mgr. Tereza Miškechová

Anotace

V originále

Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), has spread widely around the globe. Significant inter-individual differences have been observed during the course of the infection, which suggests that genetic susceptibility may be a contributing factor. CC chemokine receptor 5 (CCR5), which acts as a co-receptor for the entry of HIV-1 into cells, is promising candidate whose can have an influence on SARS-CoV-2 infection. A genetic mutation known as CCR5 Delta 32, consisting of a 32-nucleotide deletion, encodes a truncated protein that protects homozygous carriers of the deletion from HIV-1 infection. Similarly, inhibition of CCR5 seems to be protective against COVID-19. In our study, we successfully genotyped 416 first-wave SARS-CoV-2-positive infection survivors (164 asymptomatic and 252 symptomatic) for CCR5 Delta 32, comparing them with a population based sample of 2,404 subjects. We found the highest number (P=0.03) of CCR5 Delta 32 carriers in SARS-CoV-2-positive/COVID-19-asymptomatic subjects (23.8 %) and the lowest number in SARS-CoV-2-positive/COVID-19-symptomatic patients (16.7 %), with frequency in the control population in the middle (21.0 %). We conclude that the CCR5 Delta 32 I/D polymorphism may have the potential to predict the severity of SARS-CoV-2 infection.

Citovat

HUBACEK, Jaroslav A., Ladislav DUŠEK, Ondřej MÁJEK, Vaclav ADAMEK, Tereza CERVINKOVA, Dana DLOUHA, Jozef PAVEL a Vera ADAMKOVA. CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects. Physiological research. Praha: Fyziologický ústav AV ČR, 2021, roč. 70, č. 1, s. 111-115. ISSN 0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934647.

@article{1776197,
   author = {Hubacek, Jaroslav A. and Dušek, Ladislav and Májek, Ondřej and Adamek, Vaclav and Cervinkova, Tereza and Dlouha, Dana and Pavel, Jozef and Adamkova, Vera},
   article_location = {Praha},
   article_number = {1},
   doi = {http://dx.doi.org/10.33549/physiolres.934647},
   keywords = {COVID-19; CCR5; Polymorphism; Deletion; Delta 32},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological research},
   title = {CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects},
   url = {https://www.biomed.cas.cz/physiolres/pdf/2021/70_111.pdf},
   volume = {70},
   year = {2021}
}

TY  - JOUR
ID  - 1776197
AU  - Hubacek, Jaroslav A. - Dušek, Ladislav - Májek, Ondřej - Adamek, Vaclav - Cervinkova, Tereza - Dlouha, Dana - Pavel, Jozef - Adamkova, Vera
PY  - 2021
TI  - CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects
JF  - Physiological research
VL  - 70
IS  - 1
SP  - 111-115
EP  - 111-115
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - COVID-19
KW  - CCR5
KW  - Polymorphism
KW  - Deletion
KW  - Delta 32
UR  - https://www.biomed.cas.cz/physiolres/pdf/2021/70_111.pdf
N2  - Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), has spread widely around the globe. Significant inter-individual differences have been observed during the course of the infection, which suggests that genetic susceptibility may be a contributing factor. CC chemokine receptor 5 (CCR5), which acts as a co-receptor for the entry of HIV-1 into cells, is promising candidate whose can have an influence on SARS-CoV-2 infection. A genetic mutation known as CCR5 Delta 32, consisting of a 32-nucleotide deletion, encodes a truncated protein that protects homozygous carriers of the deletion from HIV-1 infection. Similarly, inhibition of CCR5 seems to be protective against COVID-19. In our study, we successfully genotyped 416 first-wave SARS-CoV-2-positive infection survivors (164 asymptomatic and 252 symptomatic) for CCR5 Delta 32, comparing them with a population based sample of 2,404 subjects. We found the highest number (P=0.03) of CCR5 Delta 32 carriers in SARS-CoV-2-positive/COVID-19-asymptomatic subjects (23.8 %) and the lowest number in SARS-CoV-2-positive/COVID-19-symptomatic patients (16.7 %), with frequency in the control population in the middle (21.0 %). We conclude that the CCR5 Delta 32 I/D polymorphism may have the potential to predict the severity of SARS-CoV-2 infection.
ER  -

HUBACEK, Jaroslav A., Ladislav DUŠEK, Ondřej MÁJEK, Vaclav ADAMEK, Tereza CERVINKOVA, Dana DLOUHA, Jozef PAVEL a Vera ADAMKOVA. CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2021, roč.~70, č.~1, s.~111-115. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934647.

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