Fibroblasts: The grey eminence of mammary gland development

J 2021

Fibroblasts: The grey eminence of mammary gland development

SUMBAL, Jakub, Denisa BELISOVÁ a Zuzana KOLEDOVÁ

Základní údaje

Originální název

Fibroblasts: The grey eminence of mammary gland development

Autoři

SUMBAL, Jakub (203 Česká republika, domácí), Denisa BELISOVÁ (703 Slovensko, domácí) a Zuzana KOLEDOVÁ (703 Slovensko, garant, domácí)

Vydání

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, LONDON, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, 1084-9521

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.499

Kód RIV

RIV/00216224:14110/21:00121780

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.semcdb.2020.10.012

UT WoS

000653461300003

Klíčová slova anglicky

Breast; Epithelial-stromal interactions; Fibroblast; Heterogeneity; Mammary gland; Microenvironment

Štítky

14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 6. 2021 13:16, Mgr. Tereza Miškechová

Anotace

V originále

The essential role of mammary gland stroma in the regulation of mammary epithelial development, function, and cancer has long been recognized. Only recently, though, the functions of individual stromal cell populations have begun to become more clarified. Mammary fibroblasts have emerged as master regulators and modulators of epithelial cell behavior through paracrine signaling, extracellular matrix production and remodeling, and through regulation of other stromal cell types. In this review article, we summarize the crucial studies that helped to untangle the roles of fibroblasts in mammary gland development. Furthermore, we discuss the origin, heterogeneity, and plasticity of mammary fibroblasts during mammary development and cancer progression.

Návaznosti

MUNI/G/1446/2018, interní kód MU

Název: Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling

Investor: Masarykova univerzita, Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling, INTERDISCIPLINARY - Mezioborové výzkumné projekty

ROZV/28/LF19/2020, interní kód MU

Název: Regulace morfogeneze epitelu mléčné žlázy pomocí mechanických sil a dynamiky signalizace

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Regulace morfogeneze epitelu mléčné žlázy pomocí mechanických sil a dynamiky signalizace, Interní rozvojové projekty

Citovat

SUMBAL, Jakub, Denisa BELISOVÁ a Zuzana KOLEDOVÁ. Fibroblasts: The grey eminence of mammary gland development. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, roč. 114, JUN 2021, s. 134-142. ISSN 1084-9521. Dostupné z: https://dx.doi.org/10.1016/j.semcdb.2020.10.012.

@article{1776282,
   author = {Sumbal, Jakub and Belisová, Denisa and Koledová, Zuzana},
   article_location = {LONDON},
   article_number = {JUN 2021},
   doi = {http://dx.doi.org/10.1016/j.semcdb.2020.10.012},
   keywords = {Breast; Epithelial-stromal interactions; Fibroblast; Heterogeneity; Mammary gland; Microenvironment},
   language = {eng},
   issn = {1084-9521},
   journal = {SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY},
   title = {Fibroblasts: The grey eminence of mammary gland development},
   url = {https://www.sciencedirect.com/science/article/pii/S1084952120301695?via%3Dihub},
   volume = {114},
   year = {2021}
}

TY  - JOUR
ID  - 1776282
AU  - Sumbal, Jakub - Belisová, Denisa - Koledová, Zuzana
PY  - 2021
TI  - Fibroblasts: The grey eminence of mammary gland development
JF  - SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
VL  - 114
IS  - JUN 2021
SP  - 134-142
EP  - 134-142
PB  - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN  - 10849521
KW  - Breast
KW  - Epithelial-stromal interactions
KW  - Fibroblast
KW  - Heterogeneity
KW  - Mammary gland
KW  - Microenvironment
UR  - https://www.sciencedirect.com/science/article/pii/S1084952120301695?via%3Dihub
N2  - The essential role of mammary gland stroma in the regulation of mammary epithelial development, function, and cancer has long been recognized. Only recently, though, the functions of individual stromal cell populations have begun to become more clarified. Mammary fibroblasts have emerged as master regulators and modulators of epithelial cell behavior through paracrine signaling, extracellular matrix production and remodeling, and through regulation of other stromal cell types. In this review article, we summarize the crucial studies that helped to untangle the roles of fibroblasts in mammary gland development. Furthermore, we discuss the origin, heterogeneity, and plasticity of mammary fibroblasts during mammary development and cancer progression.
ER  -

SUMBAL, Jakub, Denisa BELISOVÁ a Zuzana KOLEDOVÁ. Fibroblasts: The grey eminence of mammary gland development. \textit{SEMINARS IN CELL \&{} DEVELOPMENTAL BIOLOGY}. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, roč.~114, JUN 2021, s.~134-142. ISSN~1084-9521. Dostupné z: https://dx.doi.org/10.1016/j.semcdb.2020.10.012.

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