Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease

KHAIRNAR, Amit Suresh, Jana RUDÁ, Anas ARAB, Constantinos HADJISTYLLIS, Alžběta ŠEJNOHA MINSTEROVÁ, Qi SHANG, Alexandra CHOVSEPAIN, Eva DRAŽANOVÁ, Nikoletta SZABÓ, Zenon STARČUK, Irena REKTOROVÁ and Francisco PAN-MONTOJO. Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease. Journal of Neurochemistry. HOBOKEN: Wiley-Blackwell, 2021, vol. 158, No 3, p. 779-797. ISSN 0022-3042. Available from: https://dx.doi.org/10.1111/jnc.15449.

Basic information

• Original name: Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease
• Name in Czech: Zobrazování kurtózy difuze detekuje časový průběh patologických změn v perorálním rotenonovém myším modelu Parkinsonovy nemoci
• Authors: KHAIRNAR, Amit Suresh (356 India, belonging to the institution), Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution), Anas ARAB (760 Syrian Arab Republic, belonging to the institution), Constantinos HADJISTYLLIS (276 Germany), Alžběta ŠEJNOHA MINSTEROVÁ (203 Czech Republic, belonging to the institution), Qi SHANG (276 Germany), Alexandra CHOVSEPAIN (276 Germany), Eva DRAŽANOVÁ (203 Czech Republic, belonging to the institution), Nikoletta SZABÓ (348 Hungary, belonging to the institution), Zenon STARČUK (203 Czech Republic), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Francisco PAN-MONTOJO (276 Germany).
• Edition: Journal of Neurochemistry, HOBOKEN, Wiley-Blackwell, 2021, 0022-3042.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30103 Neurosciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 5.546
• RIV identification code: RIV/00216224:14740/21:00120106
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1111/jnc.15449
• UT WoS: 000669590100001
• Keywords in English: alpha synuclein; diffusion kurtosis imaging; MRI; Parkinsons disease; rotenone; tract-based spatial statistics
• Tags: 14110127, 14110516, CF MAFIL, podil, rivok
• Tags: International impact, Reviewed

Abstract

We test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone,a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging.

Links

• EF16_013/0001775, research and development project: Name: Modernizace a podpora výzkumných aktivit národní infrastruktury pro biologické a medicínské zobrazování Czech-BioImaging
• LM2015062, research and development project: Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

• MUNI/A/1249/2020, interní kód MU: Name: Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii (Acronym: SV_Farmakologie2021)

Investor: Masaryk University

• NU20-04-00294, research and development project: Name: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Investor: Ministry of Health of the CR, Diagnostics of Lewy body diseases in prodromal stage based on multimodal data analysis