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@article{1779390,
author = {Bencúrová, Petra and Baloun, Jiří and Hynšt, Jakub and Oppelt, Jan and Kubová, Hana and Pospíšilová, Šárka and Brázdil, Milan},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-021-89084-9},
keywords = {Dynamic miRNA changes; epileptogenesis; infantile and adult-onset model},
language = {eng},
issn = {2045-2322},
journal = {Nature Scientific Reports},
title = {Dynamic miRNA changes during the process of epileptogenesis in an infantile and adult-onset model},
url = {https://www.nature.com/articles/s41598-021-89084-9.pdf},
volume = {11},
year = {2021}
}
TY - JOUR
ID - 1779390
AU - Bencúrová, Petra - Baloun, Jiří - Hynšt, Jakub - Oppelt, Jan - Kubová, Hana - Pospíšilová, Šárka - Brázdil, Milan
PY - 2021
TI - Dynamic miRNA changes during the process of epileptogenesis in an infantile and adult-onset model
JF - Nature Scientific Reports
VL - 11
IS - 1
SP - 1-14
EP - 1-14
PB - NATURE RESEARCH
SN - 20452322
KW - Dynamic miRNA changes
KW - epileptogenesis
KW - infantile and adult-onset model
UR - https://www.nature.com/articles/s41598-021-89084-9.pdf
N2 - Temporal lobe epilepsy (TLE) is the most common epilepsy type. TLE onset in infancy aggravates features like severity, drug responsiveness, or development of comorbidities. These aggravations may arise from altered micro RNA (miRNA) expression specific to the early onset of the disease. Although the miRNA involvement in TLE is widely studied, the relationship between the onset-age and miRNA expression has not been addressed. Here, we investigated the miRNA profile of infantile and adult-onset TLE in rats combining sequencing and PCR. Since miRNA expression changes with the disease progression, we scrutinized miRNA dynamics across three stages: acute, latent, and chronic. We report that infantile-onset TLE leads to changes in the expression of fewer miRNAs across these stages. Interestingly, the miRNA profile in the acute stage of infantile-onset TLE overlaps in dysregulation of miR-132-5p, -205, and -211-3p with the chronic stage of the disease starting in adulthood. The analysis of putative targets linked the majority of dysregulated miRNAs with pathways involved in epilepsy. Our profiling uncovered miRNA expression characteristic for infantile and adulthood-onset epileptogenesis, suggesting the distinct biology underlying TLE in the onset age-dependent matter. Our results indicate the necessity of addressing the onset age as an important parameter in future epilepsy research.
ER -
BENCÚROVÁ, Petra, Jiří BALOUN, Jakub HYNŠT, Jan OPPELT, Hana KUBOVÁ, Šárka POSPÍŠILOVÁ a Milan BRÁZDIL. Dynamic miRNA changes during the process of epileptogenesis in an infantile and adult-onset model. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2021, roč.~11, č.~1, s.~1-14. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-021-89084-9.
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