| KUBÍNOVÁ, Renata, R. PORIZKOVA, Alice SYCHROVÁ, Oldřich FARSA, Zuzana HANÁKOVÁ, A. BACINSKA, Alois ČÍŽEK a Marie VALENTOVÁ. Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth. Journal of Enzyme Inhibition and Medicinal Chemistry. UK: Taylor & Francis, 2014, roč. 29, č. 5, s. 749-752. ISSN 1475-6366. Dostupné z: https://dx.doi.org/10.3109/14756366.2013.848204. |
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@article{1781680,
author = {Kubínová, Renata and Porizkova, R. and Sychrová, Alice and Farsa, Oldřich and Hanáková, Zuzana and Bacinska, A. and Čížek, Alois and Valentová, Marie},
article_location = {UK},
article_number = {5},
doi = {http://dx.doi.org/10.3109/14756366.2013.848204},
keywords = {alpha-glucosidase; antibacterial activity; cholinesterase; diterpenoids; rosmarinic acid},
language = {eng},
issn = {1475-6366},
journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
title = {Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth},
url = {https://pubmed.ncbi.nlm.nih.gov/24506206/},
volume = {29},
year = {2014}
}
TY - JOUR
ID - 1781680
AU - Kubínová, Renata - Porizkova, R. - Sychrová, Alice - Farsa, Oldřich - Hanáková, Zuzana - Bacinska, A. - Čížek, Alois - Valentová, Marie
PY - 2014
TI - Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
VL - 29
IS - 5
SP - 749-752
EP - 749-752
PB - Taylor & Francis
SN - 14756366
KW - alpha-glucosidase
KW - antibacterial activity
KW - cholinesterase
KW - diterpenoids
KW - rosmarinic acid
UR - https://pubmed.ncbi.nlm.nih.gov/24506206/
N2 - Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7 beta, 6 beta-dihydroxyroyleanone (2), 7 beta-acetoxy-6 beta-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and alpha-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alpha-glucosidase with IC50 values from 33 to 275 mu M. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
ER -
KUBÍNOVÁ, Renata, R. PORIZKOVA, Alice SYCHROVÁ, Oldřich FARSA, Zuzana HANÁKOVÁ, A. BACINSKA, Alois ČÍŽEK a Marie VALENTOVÁ. Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth. \textit{Journal of Enzyme Inhibition and Medicinal Chemistry}. UK: Taylor \&{} Francis, 2014, roč.~29, č.~5, s.~749-752. ISSN~1475-6366. Dostupné z: https://dx.doi.org/10.3109/14756366.2013.848204.
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