Vibrio vulnificus-Induced Necrotizing Fasciitis Complicated by
Multidrug-Resistant Acinetobacter baumannii Infection: Efficacy
of Chemical Necrectomy Using 40% Benzoic Acid

J 2023

Vibrio vulnificus-Induced Necrotizing Fasciitis Complicated by Multidrug-Resistant Acinetobacter baumannii Infection: Efficacy of Chemical Necrectomy Using 40% Benzoic Acid

LIPOVÝ, Břetislav, Radomír MAGER, Filip RAŠKA, Marketa HANSLIANOVA, Josef BLAZEK et. al.

Základní údaje

Originální název

Vibrio vulnificus-Induced Necrotizing Fasciitis Complicated by Multidrug-Resistant Acinetobacter baumannii Infection: Efficacy of Chemical Necrectomy Using 40% Benzoic Acid

Autoři

LIPOVÝ, Břetislav (203 Česká republika, domácí), Radomír MAGER (203 Česká republika, domácí), Filip RAŠKA (203 Česká republika, domácí), Marketa HANSLIANOVA (203 Česká republika), Josef BLAZEK (203 Česká republika), Hana KREMECKOVA (203 Česká republika), Ivan SUCHÁNEK (203 Česká republika) a Martin HLADÍK (703 Slovensko, garant, domácí)

Vydání

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS, THOUSAND OAKS, SAGE PUBLICATIONS INC, 2023, 1534-7346

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.700 v roce 2022

Kód RIV

RIV/00216224:14110/23:00134616

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1177/15347346211004305

UT WoS

000643459200001

Klíčová slova anglicky

Vibrio vulnificus; skin and soft tissue infection; necrotizing fasciitis; multidrug-resistant bacteria; chemical necrectomy

Štítky

14110229, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 1. 2024 09:24, Mgr. Tereza Miškechová

Anotace

V originále

Necrotizing fasciitis is a life-threatening skin and soft tissue infection associated with high morbidity and mortality in adult patients. This infection can present as either type 1 infection caused by a mixed microflora (Streptococci, Enterobacteriacae, Bacteroides sp., and Peptostreptococcus sp.), most commonly developing in patients after surgery or in diabetic patients, or as type 2. The latter type is monomicrobial and, usually, caused by group A Streptococci. Rarely, this type can be also caused by other pathogens, such as Vibrio vulnificus. V vulnificus is a small mobile Gram-negative rod capable of causing 3 types of infections in humans-gastroenteritis, primary infection of the vascular bed, and wound infections. If infecting a wound, V vulnificus can cause a life-threatening condition-necrotizing fasciitis. We present a rare case of necrotizing fasciitis developing after an insect bite followed by exposure to the seawater. Rapid propagation of the infectious complication in the region of the right lower limb led to a serious consideration of the necessity of amputation. Due to the clearly demarcated necroses and secondary skin and soft tissue infection caused by a multiresistant strain of Acinetobacter baumannii, we, however, resorted to the use of selective chemical necrectomy using 40% benzoic acid-a unique application in this kind of condition. The chemical necrectomy was successful, relatively gentle and thanks to its selectivity, vital parts of the limb remained preserved and could have been subsequently salvaged at minimum blood loss. Moreover, the antimicrobial effect of benzoic acid led to rapid decolonization of the necrosis and wound bed preparation, which allowed us to perform defect closure using split-thickness skin grafts. The patient subsequently healed without further complications and returned to normal life.

Návaznosti

NU20-05-00166, projekt VaV

Název: Nové přístupy k hojení infikovaných ran pomocí hydrogelů z přírodní pryskyřice Gum Karaya modifikovaných inovativními komponenty cílenými na multirezistentní kmeny bakterií (Akronym: NPHIRPHGK)

Investor: Ministerstvo zdravotnictví ČR, Nové přístupy k hojení infikovaných ran pomocí hydrogelů z přírodní pryskyřice Gum Karaya modifikovaných inovativními komponenty cílenými na multirezistentní kmeny bakterií, Podprogram 1 - standardní

Citovat

LIPOVÝ, Břetislav, Radomír MAGER, Filip RAŠKA, Marketa HANSLIANOVA, Josef BLAZEK, Hana KREMECKOVA, Ivan SUCHÁNEK a Martin HLADÍK. Vibrio vulnificus-Induced Necrotizing Fasciitis Complicated by Multidrug-Resistant Acinetobacter baumannii Infection: Efficacy of Chemical Necrectomy Using 40% Benzoic Acid. INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS. THOUSAND OAKS: SAGE PUBLICATIONS INC, 2023, roč. 22, č. 1, s. 200-207. ISSN 1534-7346. Dostupné z: https://dx.doi.org/10.1177/15347346211004305.

@article{1782966,
   author = {Lipový, Břetislav and Mager, Radomír and Raška, Filip and Hanslianova, Marketa and Blazek, Josef and Kremeckova, Hana and Suchánek, Ivan and Hladík, Martin},
   article_location = {THOUSAND OAKS},
   article_number = {1},
   doi = {http://dx.doi.org/10.1177/15347346211004305},
   keywords = {Vibrio vulnificus; skin and soft tissue infection; necrotizing fasciitis; multidrug-resistant bacteria; chemical necrectomy},
   language = {eng},
   issn = {1534-7346},
   journal = {INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS},
   title = {Vibrio vulnificus-Induced Necrotizing Fasciitis Complicated by Multidrug-Resistant Acinetobacter baumannii Infection: Efficacy of Chemical Necrectomy Using 40% Benzoic Acid},
   url = {https://journals.sagepub.com/doi/10.1177/15347346211004305},
   volume = {22},
   year = {2023}
}

TY  - JOUR
ID  - 1782966
AU  - Lipový, Břetislav - Mager, Radomír - Raška, Filip - Hanslianova, Marketa - Blazek, Josef - Kremeckova, Hana - Suchánek, Ivan - Hladík, Martin
PY  - 2023
TI  - Vibrio vulnificus-Induced Necrotizing Fasciitis Complicated by Multidrug-Resistant Acinetobacter baumannii Infection: Efficacy of Chemical Necrectomy Using 40% Benzoic Acid
JF  - INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
VL  - 22
IS  - 1
SP  - 200-207
EP  - 200-207
PB  - SAGE PUBLICATIONS INC
SN  - 15347346
KW  - Vibrio vulnificus
KW  - skin and soft tissue infection
KW  - necrotizing fasciitis
KW  - multidrug-resistant bacteria
KW  - chemical necrectomy
UR  - https://journals.sagepub.com/doi/10.1177/15347346211004305
N2  - Necrotizing fasciitis is a life-threatening skin and soft tissue infection associated with high morbidity and mortality in adult patients. This infection can present as either type 1 infection caused by a mixed microflora (Streptococci, Enterobacteriacae, Bacteroides sp., and Peptostreptococcus sp.), most commonly developing in patients after surgery or in diabetic patients, or as type 2. The latter type is monomicrobial and, usually, caused by group A Streptococci. Rarely, this type can be also caused by other pathogens, such as Vibrio vulnificus. V vulnificus is a small mobile Gram-negative rod capable of causing 3 types of infections in humans-gastroenteritis, primary infection of the vascular bed, and wound infections. If infecting a wound, V vulnificus can cause a life-threatening condition-necrotizing fasciitis. We present a rare case of necrotizing fasciitis developing after an insect bite followed by exposure to the seawater. Rapid propagation of the infectious complication in the region of the right lower limb led to a serious consideration of the necessity of amputation. Due to the clearly demarcated necroses and secondary skin and soft tissue infection caused by a multiresistant strain of Acinetobacter baumannii, we, however, resorted to the use of selective chemical necrectomy using 40% benzoic acid-a unique application in this kind of condition. The chemical necrectomy was successful, relatively gentle and thanks to its selectivity, vital parts of the limb remained preserved and could have been subsequently salvaged at minimum blood loss. Moreover, the antimicrobial effect of benzoic acid led to rapid decolonization of the necrosis and wound bed preparation, which allowed us to perform defect closure using split-thickness skin grafts. The patient subsequently healed without further complications and returned to normal life.
ER  -

LIPOVÝ, Břetislav, Radomír MAGER, Filip RAŠKA, Marketa HANSLIANOVA, Josef BLAZEK, Hana KREMECKOVA, Ivan SUCHÁNEK a Martin HLADÍK. Vibrio vulnificus-Induced Necrotizing Fasciitis Complicated by Multidrug-Resistant Acinetobacter baumannii Infection: Efficacy of Chemical Necrectomy Using 40\%{} Benzoic Acid. \textit{INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS}. THOUSAND OAKS: SAGE PUBLICATIONS INC, 2023, roč.~22, č.~1, s.~200-207. ISSN~1534-7346. Dostupné z: https://dx.doi.org/10.1177/15347346211004305.

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