Immunosenescence in Childhood Cancer Survivors and in Elderly:
A Comparison and Implication for Risk Stratification

J 2021

Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification

LÁZNIČKOVÁ, Petra, Kamila BENDÍČKOVÁ, Tomáš KEPÁK a Jan FRIČ

Základní údaje

Originální název

Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification

Autoři

LÁZNIČKOVÁ, Petra (203 Česká republika, domácí), Kamila BENDÍČKOVÁ (203 Česká republika), Tomáš KEPÁK (203 Česká republika, domácí) a Jan FRIČ (203 Česká republika, garant)

Vydání

Frontiers in Aging, LAUSANNE, FRONTIERS MEDIA SA, 2021, 1663-4365

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.702

Kód RIV

RIV/00216224:14110/21:00121956

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3389/fragi.2021.708788

UT WoS

001090275600001

Klíčová slova anglicky

childhood cancer survivor; immunosenescence; low-grade inflammation; accelerated aging; late effects; patient stratification; elderly

Štítky

14110321, 14110513, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 2. 2024 12:22, Mgr. Tereza Miškechová

Anotace

V originále

The population of childhood cancer survivors (CCS) has grown rapidly in recent decades. Although cured of their original malignancy, these individuals are at increased risk of serious late effects, including age-associated complications. An impaired immune system has been linked to the emergence of these conditions in the elderly and CCS, likely due to senescent immune cell phenotypes accompanied by low-grade inflammation, which in the elderly is known as “inflammaging.” Whether these observations in the elderly and CCS are underpinned by similar mechanisms is unclear. If so, existing knowledge on immunosenescent phenotypes and inflammaging might potentially serve to benefit CCS. We summarize recent findings on the immune changes in CCS and the elderly, and highlight the similarities and identify areas for future research. Improving our understanding of the underlying mechanisms and immunosenescent markers of accelerated immune aging might help us to identify individuals at increased risk of serious health complications.

Návaznosti

MUNI/A/1325/2020, interní kód MU

Název: Biomedicínské vědy

Investor: Masarykova univerzita, Biomedicínské vědy

Citovat

LÁZNIČKOVÁ, Petra, Kamila BENDÍČKOVÁ, Tomáš KEPÁK a Jan FRIČ. Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification. Frontiers in Aging. LAUSANNE: FRONTIERS MEDIA SA, 2021, roč. 2021, č. 2, s. 1-20. ISSN 1663-4365. Dostupné z: https://dx.doi.org/10.3389/fragi.2021.708788.

@article{1783117,
   author = {Lázničková, Petra and Bendíčková, Kamila and Kepák, Tomáš and Frič, Jan},
   article_location = {LAUSANNE},
   article_number = {2},
   doi = {http://dx.doi.org/10.3389/fragi.2021.708788},
   keywords = {childhood cancer survivor; immunosenescence; low-grade inflammation; accelerated aging; late effects; patient stratification; elderly},
   language = {eng},
   issn = {1663-4365},
   journal = {Frontiers in Aging},
   title = {Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification},
   url = {https://www.frontiersin.org/articles/10.3389/fragi.2021.708788/full#h9},
   volume = {2021},
   year = {2021}
}

TY  - JOUR
ID  - 1783117
AU  - Lázničková, Petra - Bendíčková, Kamila - Kepák, Tomáš - Frič, Jan
PY  - 2021
TI  - Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification
JF  - Frontiers in Aging
VL  - 2021
IS  - 2
SP  - 1-20
EP  - 1-20
PB  - FRONTIERS MEDIA SA
SN  - 16634365
KW  - childhood cancer survivor
KW  - immunosenescence
KW  - low-grade inflammation
KW  - accelerated aging
KW  - late effects
KW  - patient stratification
KW  - elderly
UR  - https://www.frontiersin.org/articles/10.3389/fragi.2021.708788/full#h9
N2  - The population of childhood cancer survivors (CCS) has grown rapidly in recent decades. Although cured of their original malignancy, these individuals are at increased risk of serious late effects, including age-associated complications. An impaired immune system has been linked to the emergence of these conditions in the elderly and CCS, likely due to senescent immune cell phenotypes accompanied by low-grade inflammation, which in the elderly is known as “inflammaging.” Whether these observations in the elderly and CCS are underpinned by similar mechanisms is unclear. If so, existing knowledge on immunosenescent phenotypes and inflammaging might potentially serve to benefit CCS. We summarize recent findings on the immune changes in CCS and the elderly, and highlight the similarities and identify areas for future research. Improving our understanding of the underlying mechanisms and immunosenescent markers of accelerated immune aging might help us to identify individuals at increased risk of serious health complications.
ER  -

LÁZNIČKOVÁ, Petra, Kamila BENDÍČKOVÁ, Tomáš KEPÁK a Jan FRIČ. Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification. \textit{Frontiers in Aging}. LAUSANNE: FRONTIERS MEDIA SA, 2021, roč.~2021, č.~2, s.~1-20. ISSN~1663-4365. Dostupné z: https://dx.doi.org/10.3389/fragi.2021.708788.

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