The kinase module of the Mediator complex: an important
signalling processor for the development and survival of plants

J 2021

The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants

AGRAWAL, Rekha, Jiří FAJKUS a Jitendra K. THAKUR

Základní údaje

Originální název

The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants

Autoři

AGRAWAL, Rekha (356 Indie), Jiří FAJKUS (203 Česká republika, domácí) a Jitendra K. THAKUR (356 Indie)

Vydání

Journal of Experimental Botany, Oxford, OXFORD UNIV PRESS, 2021, 0022-0957

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10611 Plant sciences, botany

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.298

Kód RIV

RIV/00216224:14740/21:00121997

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1093/jxb/eraa439

UT WoS

000648886400008

Klíčová slova anglicky

Arabidopsis; development; kinase module; Mediator complex; RNA polymerase II; transcription

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 6. 2022 11:19, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Mediator, a multisubunit protein complex, is a signal processor that conveys regulatory information from transcription factors to RNA polymerase II and therefore plays an important role in the regulation of gene expression. This tnegadalton complex comprises four modules, namely, the head, middle, tail, and kinase modules. The first three modules form the core part of the complex, whereas association of the kinase module is facultative. The kinase module is able to alter the function of Mediator and has been established as a major transcriptional regulator of numerous developmental and biochemical processes. The kinase module consists of MED12, MED13, CycC, and kinase CDK8. Upon association with Mediator, the kinase module can alter its structure and function dramatically. In the past decade, research has established that the kinase module is very important for plant growth and development, and in the fight against biotic and abiotic challenges. However, there has been no comprehensive review discussing these findings in detail and depth. In this review, we survey the regulation of kinase module subunits and highlight their many functions in plants. Coordination between the subunits to process different signals for optimum plant growth and development is also discussed.

Návaznosti

EF16_026/0008446, projekt VaV

Název: Integrace signálu a epigenetické reprogramování pro produktivitu rostlin

LTC20003, projekt VaV

Název: Dynamics of telomeres and rDNA loci in plant cell nuclei

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Dynamics of telomeres and rDNA loci in plant cell nuclei, INTER-COST

Citovat

AGRAWAL, Rekha, Jiří FAJKUS a Jitendra K. THAKUR. The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants. Journal of Experimental Botany. Oxford: OXFORD UNIV PRESS, 2021, roč. 72, č. 2, s. 224-240. ISSN 0022-0957. Dostupné z: https://dx.doi.org/10.1093/jxb/eraa439.

@article{1784061,
   author = {Agrawal, Rekha and Fajkus, Jiří and Thakur, Jitendra K.},
   article_location = {Oxford},
   article_number = {2},
   doi = {http://dx.doi.org/10.1093/jxb/eraa439},
   keywords = {Arabidopsis; development; kinase module; Mediator complex; RNA polymerase II; transcription},
   language = {eng},
   issn = {0022-0957},
   journal = {Journal of Experimental Botany},
   title = {The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants},
   url = {https://academic.oup.com/jxb/article/72/2/224/5908351},
   volume = {72},
   year = {2021}
}

TY  - JOUR
ID  - 1784061
AU  - Agrawal, Rekha - Fajkus, Jiří - Thakur, Jitendra K.
PY  - 2021
TI  - The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants
JF  - Journal of Experimental Botany
VL  - 72
IS  - 2
SP  - 224-240
EP  - 224-240
PB  - OXFORD UNIV PRESS
SN  - 00220957
KW  - Arabidopsis
KW  - development
KW  - kinase module
KW  - Mediator complex
KW  - RNA polymerase II
KW  - transcription
UR  - https://academic.oup.com/jxb/article/72/2/224/5908351
N2  - Mediator, a multisubunit protein complex, is a signal processor that conveys regulatory information from transcription factors to RNA polymerase II and therefore plays an important role in the regulation of gene expression. This tnegadalton complex comprises four modules, namely, the head, middle, tail, and kinase modules. The first three modules form the core part of the complex, whereas association of the kinase module is facultative. The kinase module is able to alter the function of Mediator and has been established as a major transcriptional regulator of numerous developmental and biochemical processes. The kinase module consists of MED12, MED13, CycC, and kinase CDK8. Upon association with Mediator, the kinase module can alter its structure and function dramatically. In the past decade, research has established that the kinase module is very important for plant growth and development, and in the fight against biotic and abiotic challenges. However, there has been no comprehensive review discussing these findings in detail and depth. In this review, we survey the regulation of kinase module subunits and highlight their many functions in plants. Coordination between the subunits to process different signals for optimum plant growth and development is also discussed.
ER  -

AGRAWAL, Rekha, Jiří FAJKUS a Jitendra K. THAKUR. The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants. \textit{Journal of Experimental Botany}. Oxford: OXFORD UNIV PRESS, 2021, roč.~72, č.~2, s.~224-240. ISSN~0022-0957. Dostupné z: https://dx.doi.org/10.1093/jxb/eraa439.

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