Tumor Characteristic Variations between Symptomatic and
Asymptomatic Endometrial Cancer

J 2021

Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer

VINKLEROVÁ, Petra, Markéta BEDNAŘÍKOVÁ, Luboš MINÁŘ, Michal FELSINGER, Jitka HAUSNEROVÁ et. al.

Základní údaje

Originální název

Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer

Autoři

VINKLEROVÁ, Petra (203 Česká republika, domácí), Markéta BEDNAŘÍKOVÁ (203 Česká republika, domácí), Luboš MINÁŘ (203 Česká republika, domácí), Michal FELSINGER (203 Česká republika, domácí), Jitka HAUSNEROVÁ (203 Česká republika, domácí), Petra OVESNÁ (203 Česká republika, domácí) a Vít WEINBERGER (203 Česká republika, garant, domácí)

Vydání

Healthcare, Basel, MDPI, 2021, 2227-9032

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.160

Kód RIV

RIV/00216224:14110/21:00122021

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/healthcare9070902

UT WoS

000677363300001

Klíčová slova anglicky

endometrial cancer; tumor markers; ER; PR; p53; L1CAM

Štítky

14110212, 14110230, 14110411, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 8. 2021 10:11, Mgr. Tereza Miškechová

Anotace

V originále

Endometrial cancer is the most common gynecologic malignancy in Europe and usually diagnosed in its initial stage owing to early symptoms of abnormal bleeding. There is no population screening for this disease, although it can sometimes be accidentally diagnosed in asymptomatic patients. Our study aims to determine differences in clinical and tumor characteristics between an asymptomatic and symptomatic group of patients. This unicentric prospective observational study took place in University Hospital Brno between January 2016 and December 2019. A total of 264 patients met inclusion criteria (26% asymptomatic, 74% with reported symptoms). We did not find a statistically significant difference in clinical characteristics (menopausal status, parity, age, BMI, and serum level of CA 125) between groups. According to ultrasound examination, bleeding tumors were larger (19.5 vs. 12.7 mm, p <= 0.001). Definitive histology results indicated more frequent lymphovascular space invasion (p < 0.001), along with deep myometrial (p = 0.001) and cervical (p = 0.002) invasion. There was no difference in advanced stages of the tumor. We did not substantiate statistically significant difference in immunohistochemical profile (estrogen and progesterone receptors, L1 cell adhesion molecule, tumor protein p53), which is relevant for tumor recurrence risk and survival capacity. Our conclusions affirmed that bleeding occurs more often among patients with local tumor invasion into the myometrium and cervical stroma. Final International Federation of Gynecology and Obstetrics (FIGO) stage, histology, and immunohistochemical characteristics do not significantly affect symptom appearance.

Citovat

VINKLEROVÁ, Petra, Markéta BEDNAŘÍKOVÁ, Luboš MINÁŘ, Michal FELSINGER, Jitka HAUSNEROVÁ, Petra OVESNÁ a Vít WEINBERGER. Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer. Healthcare. Basel: MDPI, 2021, roč. 9, č. 7, s. 1-9. ISSN 2227-9032. Dostupné z: https://dx.doi.org/10.3390/healthcare9070902.

@article{1784539,
   author = {Vinklerová, Petra and Bednaříková, Markéta and Minář, Luboš and Felsinger, Michal and Hausnerová, Jitka and Ovesná, Petra and Weinberger, Vít},
   article_location = {Basel},
   article_number = {7},
   doi = {http://dx.doi.org/10.3390/healthcare9070902},
   keywords = {endometrial cancer; tumor markers; ER; PR; p53; L1CAM},
   language = {eng},
   issn = {2227-9032},
   journal = {Healthcare},
   title = {Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer},
   url = {https://www.mdpi.com/2227-9032/9/7/902},
   volume = {9},
   year = {2021}
}

TY  - JOUR
ID  - 1784539
AU  - Vinklerová, Petra - Bednaříková, Markéta - Minář, Luboš - Felsinger, Michal - Hausnerová, Jitka - Ovesná, Petra - Weinberger, Vít
PY  - 2021
TI  - Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer
JF  - Healthcare
VL  - 9
IS  - 7
SP  - 1-9
EP  - 1-9
PB  - MDPI
SN  - 22279032
KW  - endometrial cancer
KW  - tumor markers
KW  - ER
KW  - PR
KW  - p53
KW  - L1CAM
UR  - https://www.mdpi.com/2227-9032/9/7/902
N2  - Endometrial cancer is the most common gynecologic malignancy in Europe and usually diagnosed in its initial stage owing to early symptoms of abnormal bleeding. There is no population screening for this disease, although it can sometimes be accidentally diagnosed in asymptomatic patients. Our study aims to determine differences in clinical and tumor characteristics between an asymptomatic and symptomatic group of patients. This unicentric prospective observational study took place in University Hospital Brno between January 2016 and December 2019. A total of 264 patients met inclusion criteria (26% asymptomatic, 74% with reported symptoms). We did not find a statistically significant difference in clinical characteristics (menopausal status, parity, age, BMI, and serum level of CA 125) between groups. According to ultrasound examination, bleeding tumors were larger (19.5 vs. 12.7 mm, p <= 0.001). Definitive histology results indicated more frequent lymphovascular space invasion (p < 0.001), along with deep myometrial (p = 0.001) and cervical (p = 0.002) invasion. There was no difference in advanced stages of the tumor. We did not substantiate statistically significant difference in immunohistochemical profile (estrogen and progesterone receptors, L1 cell adhesion molecule, tumor protein p53), which is relevant for tumor recurrence risk and survival capacity. Our conclusions affirmed that bleeding occurs more often among patients with local tumor invasion into the myometrium and cervical stroma. Final International Federation of Gynecology and Obstetrics (FIGO) stage, histology, and immunohistochemical characteristics do not significantly affect symptom appearance.
ER  -

VINKLEROVÁ, Petra, Markéta BEDNAŘÍKOVÁ, Luboš MINÁŘ, Michal FELSINGER, Jitka HAUSNEROVÁ, Petra OVESNÁ a Vít WEINBERGER. Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer. \textit{Healthcare}. Basel: MDPI, 2021, roč.~9, č.~7, s.~1-9. ISSN~2227-9032. Dostupné z: https://dx.doi.org/10.3390/healthcare9070902.

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