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@article{1784759, author = {Kos, Jiří and Goněc, Tomáš and Oravec, Michal and Jendrzejewska, Izabela and Jampílek, Josef}, article_number = {14}, doi = {http://dx.doi.org/10.3390/molecules26144336}, keywords = {hydroxynaphthalene-carboxamides; PET inhibition; spinach chloroplasts; structure-activity relationships}, language = {eng}, issn = {1420-3049}, journal = {Molecules}, title = {Photosynthesis-Inhibiting Activity of N-(Disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamides}, url = {https://www.mdpi.com/1420-3049/26/14/4336}, volume = {26}, year = {2021} }
TY - JOUR ID - 1784759 AU - Kos, Jiří - Goněc, Tomáš - Oravec, Michal - Jendrzejewska, Izabela - Jampílek, Josef PY - 2021 TI - Photosynthesis-Inhibiting Activity of N-(Disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamides JF - Molecules VL - 26 IS - 14 SP - 1-9 EP - 1-9 PB - MDPI Basel SN - 14203049 KW - hydroxynaphthalene-carboxamides KW - PET inhibition KW - spinach chloroplasts KW - structure-activity relationships UR - https://www.mdpi.com/1420-3049/26/14/4336 N2 - A set of twenty-four 3-hydroxynaphthalene-2-carboxanilides, disubstituted on the anilide ring by combinations of methoxy/methyl/fluoro/chloro/bromo and ditrifluoromethyl groups at different positions, was prepared. The compounds were tested for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. N-(3,5-Difluorophenyl)-, N-(3,5-dimethylphenyl)-, N-(2,5-difluorophenyl)- and N-(2,5-dimethylphenyl)-3-hydroxynaphthalene-2-carboxamides showed the highest PET-inhibiting activity (IC50 similar to 10 mu M) within the series. These compounds were able to inhibit PET in photosystem II. It has been found that PET-inhibiting activity strongly depends on the position of the individual substituents on the anilide ring and on the lipophilicity of the compounds. The electron-withdrawing properties of the substituents contribute towards the PET activity of these compounds. ER -
KOS, Jiří, Tomáš GONĚC, Michal ORAVEC, Izabela JENDRZEJEWSKA a Josef JAMPÍLEK. Photosynthesis-Inhibiting Activity of N-(Disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamides. \textit{Molecules}. MDPI Basel, 2021, roč.~26, č.~14, s.~1-9. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules26144336.
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