Side Effects of mRNA-Based and Viral Vector-Based COVID-19
Vaccines among German Healthcare Workers

J 2021

Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers

KLUGAR, Miloslav, Abanoub RIAD, Mohamed MEKHEMAR, Jonas CONRAD, Mayte BUCHBENDER et. al.

Základní údaje

Originální název

Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers

Autoři

KLUGAR, Miloslav (203 Česká republika, domácí), Abanoub RIAD (818 Egypt, domácí), Mohamed MEKHEMAR, Jonas CONRAD, Mayte BUCHBENDER, Hans-Peter HOWALDT a Sameh ATTIA (garant)

Vydání

Biology, Basel, MDPI, 2021, 2079-7737

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10602 Biology , Evolutionary biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.168

Kód RIV

RIV/00216224:14110/21:00122064

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/biology10080752

UT WoS

000688819200001

Klíčová slova anglicky

adverse effects; BTN162 vaccine; ChAdOx1 COVID-19 vaccine; cross-sectional studies; COVID-19 vaccines; drug-related side effects and adverse reactions; Germany; health personnel; mRNA-1273 vaccine; prevalence

Štítky

14110525, 14119612, 14119613, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 9. 2021 09:52, Mgr. Tereza Miškechová

Anotace

V originále

Background: the increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was carried out using an online questionnaire validated and tested for a priori reliability. The questionnaire inquired about demographic data, medical and COVID-19-related anamneses, and local, systemic, oral, and skin-related side effects following COVID-19 vaccination; Results: out of the 599 participating healthcare workers, 72.3% were females, and 79.1% received mRNA-based vaccines, while 20.9% received a viral vector-based vaccine. 88.1% of the participants reported at least one side effect. Injection site pain (75.6%) was the most common local side effect, and headache/fatigue (53.6%), muscle pain (33.2%), malaise (25%), chills (23%), and joint pain (21.2%) were the most common systemic side effects. The vast majority (84.9%) of side effects resolved within 1–3 days post-vaccination; Conclusions: the mRNA-based vaccines were associated with a higher prevalence of local side effects (78.3% vs. 70.4%; Sig. = 0.064), while the viral vector-based vaccine was associated with a higher prevalence of systemic side effects (87.2% vs. 61%; Sig. < 0.001). Females and the younger age group were associated with an increased risk of side effects either after mRNA-based or viral vector-based vaccines. The gender- and age-based differences warrant further rigorous investigation and standardized methodology.

Návaznosti

LTC20031, projekt VaV

Název: Towards an International Network for Evidence-based Research in Clinical Health Research in the Czech Republic

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Towards an International Network for Evidence-based Research in Clinical Health Research in the Czech Republic, INTER-COST

MUNI/A/1608/2020, interní kód MU

Název: Prohlubování znalostí v oblasti zdravotních rizik a benefitů výživy, prostředí a životního stylu III

Investor: Masarykova univerzita, Prohlubování znalostí v oblasti zdravotních rizik a benefitů výživy, prostředí a životního stylu III

MUNI/IGA/1543/2020, interní kód MU

Název: Evidence-based Practice of Healthcare Professionals and Students in the Czech Republic (Akronym: Evidence-Based Practice in Czechia)

Investor: Masarykova univerzita, Evidence-based Practice of Healthcare Professionals and Students in the Czech Republic

Citovat

KLUGAR, Miloslav, Abanoub RIAD, Mohamed MEKHEMAR, Jonas CONRAD, Mayte BUCHBENDER, Hans-Peter HOWALDT a Sameh ATTIA. Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers. Biology. Basel: MDPI, 2021, roč. 10, č. 8, s. 1-21. ISSN 2079-7737. Dostupné z: https://dx.doi.org/10.3390/biology10080752.

@article{1785584,
   author = {Klugar, Miloslav and Riad, Abanoub and Mekhemar, Mohamed and Conrad, Jonas and Buchbender, Mayte and Howaldt, HansandPeter and Attia, Sameh},
   article_location = {Basel},
   article_number = {8},
   doi = {http://dx.doi.org/10.3390/biology10080752},
   keywords = {adverse effects; BTN162 vaccine; ChAdOx1 COVID-19 vaccine; cross-sectional studies; COVID-19 vaccines; drug-related side effects and adverse reactions; Germany; health personnel; mRNA-1273 vaccine; prevalence},
   language = {eng},
   issn = {2079-7737},
   journal = {Biology},
   title = {Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers},
   url = {https://www.mdpi.com/2079-7737/10/8/752},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1785584
AU  - Klugar, Miloslav - Riad, Abanoub - Mekhemar, Mohamed - Conrad, Jonas - Buchbender, Mayte - Howaldt, Hans-Peter - Attia, Sameh
PY  - 2021
TI  - Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers
JF  - Biology
VL  - 10
IS  - 8
SP  - 1-21
EP  - 1-21
PB  - MDPI
SN  - 20797737
KW  - adverse effects
KW  - BTN162 vaccine
KW  - ChAdOx1 COVID-19 vaccine
KW  - cross-sectional studies
KW  - COVID-19 vaccines
KW  - drug-related side effects and adverse reactions
KW  - Germany
KW  - health personnel
KW  - mRNA-1273 vaccine
KW  - prevalence
UR  - https://www.mdpi.com/2079-7737/10/8/752
N2  - Background: the increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was carried out using an online questionnaire validated and tested for a priori reliability. The questionnaire inquired about demographic data, medical and COVID-19-related anamneses, and local, systemic, oral, and skin-related side effects following COVID-19 vaccination; Results: out of the 599 participating healthcare workers, 72.3% were females, and 79.1% received mRNA-based vaccines, while 20.9% received a viral vector-based vaccine. 88.1% of the participants reported at least one side effect. Injection site pain (75.6%) was the most common local side effect, and headache/fatigue (53.6%), muscle pain (33.2%), malaise (25%), chills (23%), and joint pain (21.2%) were the most common systemic side effects. The vast majority (84.9%) of side effects resolved within 1–3 days post-vaccination; Conclusions: the mRNA-based vaccines were associated with a higher prevalence of local side effects (78.3% vs. 70.4%; Sig. = 0.064), while the viral vector-based vaccine was associated with a higher prevalence of systemic side effects (87.2% vs. 61%; Sig. < 0.001). Females and the younger age group were associated with an increased risk of side effects either after mRNA-based or viral vector-based vaccines. The gender- and age-based differences warrant further rigorous investigation and standardized methodology.
ER  -

KLUGAR, Miloslav, Abanoub RIAD, Mohamed MEKHEMAR, Jonas CONRAD, Mayte BUCHBENDER, Hans-Peter HOWALDT a Sameh ATTIA. Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers. \textit{Biology}. Basel: MDPI, 2021, roč.~10, č.~8, s.~1-21. ISSN~2079-7737. Dostupné z: https://dx.doi.org/10.3390/biology10080752.

Podrobný výpis o publikaci