Structural correlates of trauma-induced hyperarousal in mice

J 2021

Structural correlates of trauma-induced hyperarousal in mice

RUAT, Julia, Daniel E. HEINZ, Florian P. BINDER, Tibor ŠTARK, Robert NEUNER et. al.

Základní údaje

Originální název

Structural correlates of trauma-induced hyperarousal in mice

Autoři

RUAT, Julia, Daniel E. HEINZ, Florian P. BINDER, Tibor ŠTARK (703 Slovensko, domácí), Robert NEUNER, Alice HARTMANN, Paul M. KAPLICK, Alon CHEN, Michael CZISCH a Carsten T. WOTJAK (garant)

Vydání

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2021, 0278-5846

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.201

Kód RIV

RIV/00216224:14110/21:00122080

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.pnpbp.2021.110404

UT WoS

000685538900013

Klíčová slova anglicky

Post-traumatic stress disorder; Hyperarousal; Magnetic resonance imaging; Grey matter volume; Animal model

Štítky

14110516, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 2. 2022 08:35, Mgr. Tereza Miškechová

Anotace

V originále

Post-traumatic stress disorder (PTSD) is a chronic disease caused by traumatic incidents. Numerous studies have revealed grey matter volume differences in affected individuals. The nature of the disease renders it difficult to distinguish between a priori versus a posteriori changes. To overcome this difficulty, we studied the consequences of a traumatic event on brain morphology in mice before and 4 weeks after exposure to brief foot shocks (or sham treatment), and correlated morphology with symptoms of hyperarousal. In the latter context, we assessed hyperarousal upon confrontation with acoustic, visual, or composite (acoustic/visual/tactile) threats and integrated the individual readouts into a single Hyperarousal Score using logistic regression analysis. MRI scans with subsequent whole-brain deformation-based morphometry (DBM) analysis revealed a volume decrease of the dorsal hippocampus and an increase of the reticular nucleus in shocked mice when compared to non-shocked controls. Using the Hyperarousal Score as regressor for the post-exposure MRI measurement, we observed negative correlations with several brain structures including the dorsal hippocampus. If the development of changes with respect to the basal MRI was considered, reduction in globus pallidus volume reflected hyperarousal severity. Our findings demonstrate that a brief traumatic incident can cause volume changes in defined brain structures and suggest the globus pallidus as an important hub for the control of fear responses to threatening stimuli of different sensory modalities.

Návaznosti

MUNI/A/1249/2020, interní kód MU

Název: Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii (Akronym: SV_Farmakologie2021)

Investor: Masarykova univerzita, Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii

Citovat

RUAT, Julia, Daniel E. HEINZ, Florian P. BINDER, Tibor ŠTARK, Robert NEUNER, Alice HARTMANN, Paul M. KAPLICK, Alon CHEN, Michael CZISCH a Carsten T. WOTJAK. Structural correlates of trauma-induced hyperarousal in mice. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, roč. 111, December 2021, s. 1-10. ISSN 0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2021.110404.

@article{1785860,
   author = {Ruat, Julia and Heinz, Daniel E. and Binder, Florian P. and Štark, Tibor and Neuner, Robert and Hartmann, Alice and Kaplick, Paul M. and Chen, Alon and Czisch, Michael and Wotjak, Carsten T.},
   article_location = {OXFORD},
   article_number = {December 2021},
   doi = {http://dx.doi.org/10.1016/j.pnpbp.2021.110404},
   keywords = {Post-traumatic stress disorder; Hyperarousal; Magnetic resonance imaging; Grey matter volume; Animal model},
   language = {eng},
   issn = {0278-5846},
   journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY},
   title = {Structural correlates of trauma-induced hyperarousal in mice},
   url = {https://www.sciencedirect.com/science/article/pii/S0278584621001639?via%3Dihub},
   volume = {111},
   year = {2021}
}

TY  - JOUR
ID  - 1785860
AU  - Ruat, Julia - Heinz, Daniel E. - Binder, Florian P. - Štark, Tibor - Neuner, Robert - Hartmann, Alice - Kaplick, Paul M. - Chen, Alon - Czisch, Michael - Wotjak, Carsten T.
PY  - 2021
TI  - Structural correlates of trauma-induced hyperarousal in mice
JF  - PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
VL  - 111
IS  - December 2021
SP  - 1-10
EP  - 1-10
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 02785846
KW  - Post-traumatic stress disorder
KW  - Hyperarousal
KW  - Magnetic resonance imaging
KW  - Grey matter volume
KW  - Animal model
UR  - https://www.sciencedirect.com/science/article/pii/S0278584621001639?via%3Dihub
N2  - Post-traumatic stress disorder (PTSD) is a chronic disease caused by traumatic incidents. Numerous studies have revealed grey matter volume differences in affected individuals. The nature of the disease renders it difficult to distinguish between a priori versus a posteriori changes. To overcome this difficulty, we studied the consequences of a traumatic event on brain morphology in mice before and 4 weeks after exposure to brief foot shocks (or sham treatment), and correlated morphology with symptoms of hyperarousal. In the latter context, we assessed hyperarousal upon confrontation with acoustic, visual, or composite (acoustic/visual/tactile) threats and integrated the individual readouts into a single Hyperarousal Score using logistic regression analysis. MRI scans with subsequent whole-brain deformation-based morphometry (DBM) analysis revealed a volume decrease of the dorsal hippocampus and an increase of the reticular nucleus in shocked mice when compared to non-shocked controls. Using the Hyperarousal Score as regressor for the post-exposure MRI measurement, we observed negative correlations with several brain structures including the dorsal hippocampus. If the development of changes with respect to the basal MRI was considered, reduction in globus pallidus volume reflected hyperarousal severity. Our findings demonstrate that a brief traumatic incident can cause volume changes in defined brain structures and suggest the globus pallidus as an important hub for the control of fear responses to threatening stimuli of different sensory modalities.
ER  -

RUAT, Julia, Daniel E. HEINZ, Florian P. BINDER, Tibor ŠTARK, Robert NEUNER, Alice HARTMANN, Paul M. KAPLICK, Alon CHEN, Michael CZISCH a Carsten T. WOTJAK. Structural correlates of trauma-induced hyperarousal in mice. \textit{PROGRESS IN NEURO-PSYCHOPHARMACOLOGY \&{} BIOLOGICAL PSYCHIATRY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, roč.~111, December 2021, s.~1-10. ISSN~0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2021.110404.

Podrobný výpis o publikaci