Helicobacter pylori infection and other bacteria in pancreatic
cancer and autoimmune pancreatitis

J 2021

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Jiří DOLINA, Jitka VACULOVÁ et. al.

Základní údaje

Originální název

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

Autoři

KUNOVSKÝ, Lumír (203 Česká republika, domácí), Petr DÍTĚ (203 Česká republika, domácí), Petr JABANDŽIEV (203 Česká republika, domácí), Jiří DOLINA (203 Česká republika, domácí), Jitka VACULOVÁ (203 Česká republika, domácí), Martin BLAHO (203 Česká republika), Martina BOJKOVA (203 Česká republika), Jana DVORACKOVA (203 Česká republika), Magdalena UVIROVA (203 Česká republika), Zdeněk KALA (203 Česká republika, domácí) a Jan TRNA (203 Česká republika, garant, domácí)

Vydání

World Journal of Gastrointestinal Oncology, Pleasanton, Baishideng Publishing Group, 2021, 1948-5204

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.404

Kód RIV

RIV/00216224:14110/21:00120117

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4251/wjgo.v13.i8.835

UT WoS

000691097800005

Klíčová slova anglicky

Helicobacter pylori; Pancreatic cancer; Autoimmune pancreatitis; Carcinogenesis; Microbiome; Molecular mimicry

Štítky

14110213, 14110223, 14110317, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 3. 2022 07:19, Mgr. Tereza Miškechová

Anotace

V originále

Helicobacter pylori (H. pylori) is an infectious agent influencing as much as 50% of the world’s population. It is the causative agent for several diseases, most especially gastric and duodenal peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach. A number of other, extragastric manifestations also are associated with H. pylori infection. These include neurological disorders, such as Alzheimer’s disease, demyelinating multiple sclerosis and Parkinson’s disease. There is also evidence for a relationship between H. pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma. Generally little is known about the relationship between H. pylori infection and diseases of the pancreas. Most evidence about H. pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis. There is data (albeit not fully consistent) indicating modestly increased pancreatic cancer risk in H. pylori-positive patients. The pathogenetic mechanism of this increase is not yet fully elucidated, but several theories have been proposed. Reduction of antral D-cells in H. pylori-positive patients causes a suppression of somatostatin secretion that, in turn, stimulates increased secretin secretion. That stimulates pancreatic growth and thus increases the risk of carcinogenesis. Alternatively, H. pylori, as a part of microbiome dysbiosis and the so-called oncobiome, is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation. The role of H. pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins (mostly enzymes) of H. pylori and pancreatic tissue. Patients with autoimmune pancreatitis often show positivity for antibodies against H. pylori proteins. H. pylori, as a part of microbiome dysbiosis, also is viewed as a potential trigger of autoimmune inflammation of the pancreas. It is precisely these relationships (and associated equivocal conclusions) that constitute a center of attention among pancreatologists, immunologists and pathologists. In order to obtain clear and valid results, more studies on sufficiently large cohorts of patients are needed. The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research. Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer.

Návaznosti

NU20-03-00126, projekt VaV

Název: Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu

Investor: Ministerstvo zdravotnictví ČR, Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu, Podprogram 1 - standardní

Citovat

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Jiří DOLINA, Jitka VACULOVÁ, Martin BLAHO, Martina BOJKOVA, Jana DVORACKOVA, Magdalena UVIROVA, Zdeněk KALA a Jan TRNA. Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis. World Journal of Gastrointestinal Oncology. Pleasanton: Baishideng Publishing Group, 2021, roč. 13, č. 8, s. 835-844. ISSN 1948-5204. Dostupné z: https://dx.doi.org/10.4251/wjgo.v13.i8.835.

@article{1786627,
   author = {Kunovský, Lumír and Dítě, Petr and Jabandžiev, Petr and Dolina, Jiří and Vaculová, Jitka and Blaho, Martin and Bojkova, Martina and Dvorackova, Jana and Uvirova, Magdalena and Kala, Zdeněk and Trna, Jan},
   article_location = {Pleasanton},
   article_number = {8},
   doi = {http://dx.doi.org/10.4251/wjgo.v13.i8.835},
   keywords = {Helicobacter pylori; Pancreatic cancer; Autoimmune pancreatitis; Carcinogenesis; Microbiome; Molecular mimicry},
   language = {eng},
   issn = {1948-5204},
   journal = {World Journal of Gastrointestinal Oncology},
   title = {Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis},
   url = {https://www.wjgnet.com/1948-5204/full/v13/i8/835.htm},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1786627
AU  - Kunovský, Lumír - Dítě, Petr - Jabandžiev, Petr - Dolina, Jiří - Vaculová, Jitka - Blaho, Martin - Bojkova, Martina - Dvorackova, Jana - Uvirova, Magdalena - Kala, Zdeněk - Trna, Jan
PY  - 2021
TI  - Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis
JF  - World Journal of Gastrointestinal Oncology
VL  - 13
IS  - 8
SP  - 835-844
EP  - 835-844
PB  - Baishideng Publishing Group
SN  - 19485204
KW  - Helicobacter pylori
KW  - Pancreatic cancer
KW  - Autoimmune pancreatitis
KW  - Carcinogenesis
KW  - Microbiome
KW  - Molecular mimicry
UR  - https://www.wjgnet.com/1948-5204/full/v13/i8/835.htm
N2  - Helicobacter pylori (H. pylori) is an infectious agent influencing as much as 50% of the world’s population. It is the causative agent for several diseases, most especially gastric and duodenal peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach. A number of other, extragastric manifestations also are associated with H. pylori infection. These include neurological disorders, such as Alzheimer’s disease, demyelinating multiple sclerosis and Parkinson’s disease. There is also evidence for a relationship between H. pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma. Generally little is known about the relationship between H. pylori infection and diseases of the pancreas. Most evidence about H. pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis. There is data (albeit not fully consistent) indicating modestly increased pancreatic cancer risk in H. pylori-positive patients. The pathogenetic mechanism of this increase is not yet fully elucidated, but several theories have been proposed. Reduction of antral D-cells in H. pylori-positive patients causes a suppression of somatostatin secretion that, in turn, stimulates increased secretin secretion. That stimulates pancreatic growth and thus increases the risk of carcinogenesis. Alternatively, H. pylori, as a part of microbiome dysbiosis and the so-called oncobiome, is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation. The role of H. pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins (mostly enzymes) of H. pylori and pancreatic tissue. Patients with autoimmune pancreatitis often show positivity for antibodies against H. pylori proteins. H. pylori, as a part of microbiome dysbiosis, also is viewed as a potential trigger of autoimmune inflammation of the pancreas. It is precisely these relationships (and associated equivocal conclusions) that constitute a center of attention among pancreatologists, immunologists and pathologists. In order to obtain clear and valid results, more studies on sufficiently large cohorts of patients are needed. The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research. Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer.
ER  -

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Jiří DOLINA, Jitka VACULOVÁ, Martin BLAHO, Martina BOJKOVA, Jana DVORACKOVA, Magdalena UVIROVA, Zdeněk KALA a Jan TRNA. Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis. \textit{World Journal of Gastrointestinal Oncology}. Pleasanton: Baishideng Publishing Group, 2021, roč.~13, č.~8, s.~835-844. ISSN~1948-5204. Dostupné z: https://dx.doi.org/10.4251/wjgo.v13.i8.835.

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