2021
Human Granulosa Cells-Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis
DOMPE, C., M. KULUS, K. STEFANSKA, W. KRANC, B. CHERMULA et. al.Základní údaje
Originální název
Human Granulosa Cells-Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis
Autoři
DOMPE, C., M. KULUS, K. STEFANSKA, W. KRANC, B. CHERMULA, R. BRYL, W. PIENKOWSKI, M. J. NAWROCKI, J. N. PETITTE, B. STELMACH, P. MOZDZIAK, Michal JEŠETA (203 Česká republika, domácí), L. PAWELCZYK, J. M. JASKOWSKI, H. PIOTROWSKA-KEMPISTY, R. Z. SPACZYNSKI, M. NOWICKI a B. KEMPISTY (garant)
Vydání
Cells, Basel, MDPI, 2021, 2073-4409
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10601 Cell biology
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 7.666
Kód RIV
RIV/00216224:14110/21:00122117
Organizační jednotka
Lékařská fakulta
UT WoS
000665519800001
Klíčová slova anglicky
stem cells; granulosa cells; cumulus cells; translational medicine; miRNA; follicular angiogenesis
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 18. 8. 2021 13:40, Mgr. Tereza Miškechová
Anotace
V originále
The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and granulosa cells (GCs). Two different types of GCs, mural GCs and cumulus cells (CCs), serve different functions during folliculogenesis. Mural GCs produce oestrogen during the follicular phase and progesterone after ovulation, while CCs surround the oocyte tightly and form the cumulus oophurus and corona radiata inner cell layer. CCs are also engaged in bi-directional metabolite exchange with the oocyte, as they form gap-junctions, which are crucial for both the oocyte's proper maturation and GC proliferation. However, the function of both GCs and CCs is dependent on proper follicular angiogenesis. Aside from participating in complex molecular interplay with the oocyte, the ovarian follicular cells exhibit stem-like properties, characteristic of mesenchymal stem cells (MSCs). Both GCs and CCs remain under the influence of various miRNAs, and some of them may contribute to polycystic ovary syndrome (PCOS) or premature ovarian insufficiency (POI) occurrence. Considering increasing female fertility problems worldwide, it is of interest to develop new strategies enhancing assisted reproductive techniques. Therefore, it is important to carefully consider GCs as ovarian stem cells in terms of the cellular features and molecular pathways involved in their development and interactions as well as outline their possible application in translational medicine.