The Clinical Significance of DJ1 and L1CAM Serum Level
Monitoring in Patients with Endometrial Cancer

J 2021

The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer

BEDNAŘÍKOVÁ, Markéta, Petra VINKLEROVÁ, Jana GOTTWALDOVÁ, Petra OVESNÁ, Jitka HAUSNEROVÁ et. al.

Základní údaje

Originální název

The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer

Autoři

BEDNAŘÍKOVÁ, Markéta (203 Česká republika, domácí), Petra VINKLEROVÁ (203 Česká republika, domácí), Jana GOTTWALDOVÁ (203 Česká republika, domácí), Petra OVESNÁ (203 Česká republika, domácí), Jitka HAUSNEROVÁ (203 Česká republika, domácí), Luboš MINÁŘ (203 Česká republika, domácí), Michal FELSINGER (203 Česká republika, domácí), Dalibor VALÍK (203 Česká republika, domácí), Zdeňka ČERMÁKOVÁ (203 Česká republika, domácí) a Vít WEINBERGER (203 Česká republika, garant, domácí)

Vydání

Journal of Clinical Medicine, Basel, MDPI, 2021, 2077-0383

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.964

Kód RIV

RIV/00216224:14110/21:00122136

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/jcm10122640

UT WoS

000666157800001

Klíčová slova anglicky

tumor markers; endometrial cancer; DJ1; L1CAM

Štítky

14110212, 14110230, 14110411, 14110616, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 10. 2021 12:48, Mgr. Tereza Miškechová

Anotace

V originále

Circulating tumor markers are not routinely used in patients with endometrial cancer (EC). This pilot study evaluated the role of monitoring new biomarkers DJ1 and L1CAM, in correlation with CA125 and HE4, for the effects of anticancer treatment and preoperative management in EC patients. Serial serum levels of DJ1, L1CAM, CA125 and HE4 were collected in 65 enrolled patients. Serum DJ1, L1CAM, CA125 and HE4 levels were significantly higher at the time of diagnosis compared to those measured during follow-up (FU). In patients with recurrent disease, serum DJ1, CA125 and HE4 levels were significantly higher at the time of recurrence compared to levels in disease-free patients. Serum L1CAM levels were also higher in patients with recurrence but without reaching statistical significance. While DJ1 levels were not affected by any of the observed patient-related characteristics, L1CAM levels were significantly higher in patients with age >= 60 years who were overweight. At the time of EC diagnosis, DJ1 and L1CAM serum levels did not correlate with stage, histological type or risk of recurrence. This is a preliminary description of the potential of serial DJ1 and L1CAM serum level measurement for monitoring the effects of treatment in EC patients.

Citovat

BEDNAŘÍKOVÁ, Markéta, Petra VINKLEROVÁ, Jana GOTTWALDOVÁ, Petra OVESNÁ, Jitka HAUSNEROVÁ, Luboš MINÁŘ, Michal FELSINGER, Dalibor VALÍK, Zdeňka ČERMÁKOVÁ a Vít WEINBERGER. The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer. Journal of Clinical Medicine. Basel: MDPI, 2021, roč. 10, č. 12, s. 1-14. ISSN 2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm10122640.

@article{1786894,
   author = {Bednaříková, Markéta and Vinklerová, Petra and Gottwaldová, Jana and Ovesná, Petra and Hausnerová, Jitka and Minář, Luboš and Felsinger, Michal and Valík, Dalibor and Čermáková, Zdeňka and Weinberger, Vít},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/jcm10122640},
   keywords = {tumor markers; endometrial cancer; DJ1; L1CAM},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer},
   url = {https://www.mdpi.com/2077-0383/10/12/2640},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1786894
AU  - Bednaříková, Markéta - Vinklerová, Petra - Gottwaldová, Jana - Ovesná, Petra - Hausnerová, Jitka - Minář, Luboš - Felsinger, Michal - Valík, Dalibor - Čermáková, Zdeňka - Weinberger, Vít
PY  - 2021
TI  - The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer
JF  - Journal of Clinical Medicine
VL  - 10
IS  - 12
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 20770383
KW  - tumor markers
KW  - endometrial cancer
KW  - DJ1
KW  - L1CAM
UR  - https://www.mdpi.com/2077-0383/10/12/2640
N2  - Circulating tumor markers are not routinely used in patients with endometrial cancer (EC). This pilot study evaluated the role of monitoring new biomarkers DJ1 and L1CAM, in correlation with CA125 and HE4, for the effects of anticancer treatment and preoperative management in EC patients. Serial serum levels of DJ1, L1CAM, CA125 and HE4 were collected in 65 enrolled patients. Serum DJ1, L1CAM, CA125 and HE4 levels were significantly higher at the time of diagnosis compared to those measured during follow-up (FU). In patients with recurrent disease, serum DJ1, CA125 and HE4 levels were significantly higher at the time of recurrence compared to levels in disease-free patients. Serum L1CAM levels were also higher in patients with recurrence but without reaching statistical significance. While DJ1 levels were not affected by any of the observed patient-related characteristics, L1CAM levels were significantly higher in patients with age >= 60 years who were overweight. At the time of EC diagnosis, DJ1 and L1CAM serum levels did not correlate with stage, histological type or risk of recurrence. This is a preliminary description of the potential of serial DJ1 and L1CAM serum level measurement for monitoring the effects of treatment in EC patients.
ER  -

BEDNAŘÍKOVÁ, Markéta, Petra VINKLEROVÁ, Jana GOTTWALDOVÁ, Petra OVESNÁ, Jitka HAUSNEROVÁ, Luboš MINÁŘ, Michal FELSINGER, Dalibor VALÍK, Zdeňka ČERMÁKOVÁ a Vít WEINBERGER. The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2021, roč.~10, č.~12, s.~1-14. ISSN~2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm10122640.

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