Development of a New Risk Score for Stratification of Women
with Gestational Diabetes Mellitus at High Risk of Persisting
Postpartum Glucose Intolerance Using Routinely Assessed
Parameters

J 2021

Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Lukáš PÁCAL, Veronika ŤÁPALOVÁ, Silvie SEBESTOVA et. al.

Základní údaje

Originální název

Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters

Autoři

BARTÁKOVÁ, Vendula (203 Česká republika, garant, domácí), Beáta BARÁTOVÁ (703 Slovensko, domácí), Lukáš PÁCAL (203 Česká republika, domácí), Veronika ŤÁPALOVÁ (203 Česká republika), Silvie SEBESTOVA (203 Česká republika), Petr JANKŮ (203 Česká republika, domácí) a Kateřina KAŇKOVÁ (203 Česká republika, domácí)

Vydání

LIFE-BASEL, BASEL, MDPI, 2021, 2075-1729

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10606 Microbiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.253

Kód RIV

RIV/00216224:14110/21:00120124

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/life11060464

UT WoS

000666427900001

Klíčová slova anglicky

gestational diabetes mellitus; persisting glucose intolerance postpartum; risk score; peripartal outcomes

Štítky

14110518, 14110611, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 2. 2022 11:03, Mgr. Tereza Miškechová

Anotace

V originále

The aims of the study were (i) to find predictive factors for early postpartum conversion of gestational diabetes mellitus (GDM) into persisting glucose intolerance (PGI), (ii) to evaluate potential differences in adverse perinatal outcomes in GDM women with and without early postpartum PGI and, finally, (iii) to establish a risk score to predict postpartum PGI. A cross-sectional study comprised 244 GDM patients with known age, parity, positive family history of diabetes, pre-gestational BMI, comorbidities, smoking history, results of mid-trimester oral glucose tolerance test, HbA1c, obstetric complications, neonatal outcomes and mode of delivery. A risk score was calculated using parameters with highest odds ratios in a statistic scoring model. Significant differences between women with and without PGI postpartum were ascertained for mid-trimester fasting plasma glucose (p < 0.001), HbA1c above 42 mmol/mol (p = 0.035), prevalence of obesity (p = 0.007), hypothyroidism, family history of diabetes and smoking. We also observed higher incidence of prolonged and complicated delivery in PGI group (p = 0.04 and 0.007, respectively). In conclusion, this study identified several parameters with predictive potential for early PGI and also adverse peripartal outcomes. We established a simple risk-stratification score for PGI prediction applicable for GDM affected women prior their leaving maternity ward. Yet, given a relatively small sample size as a main limitation of this study, the proposed score should be validated in the larger cohort.

Návaznosti

NV18-01-00046, projekt VaV

Název: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministerstvo zdravotnictví ČR, Genetické skóre v predikci rizika diabetu a jeho komplikací

Citovat

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Lukáš PÁCAL, Veronika ŤÁPALOVÁ, Silvie SEBESTOVA, Petr JANKŮ a Kateřina KAŇKOVÁ. Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters. LIFE-BASEL. BASEL: MDPI, 2021, roč. 11, č. 6, s. 1-10. ISSN 2075-1729. Dostupné z: https://dx.doi.org/10.3390/life11060464.

@article{1787357,
   author = {Bartáková, Vendula and Barátová, Beáta and Pácal, Lukáš and Ťápalová, Veronika and Sebestova, Silvie and Janků, Petr and Kaňková, Kateřina},
   article_location = {BASEL},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/life11060464},
   keywords = {gestational diabetes mellitus; persisting glucose intolerance postpartum; risk score; peripartal outcomes},
   language = {eng},
   issn = {2075-1729},
   journal = {LIFE-BASEL},
   title = {Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters},
   url = {https://www.mdpi.com/2075-1729/11/6/464},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1787357
AU  - Bartáková, Vendula - Barátová, Beáta - Pácal, Lukáš - Ťápalová, Veronika - Sebestova, Silvie - Janků, Petr - Kaňková, Kateřina
PY  - 2021
TI  - Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters
JF  - LIFE-BASEL
VL  - 11
IS  - 6
SP  - 1-10
EP  - 1-10
PB  - MDPI
SN  - 20751729
KW  - gestational diabetes mellitus
KW  - persisting glucose intolerance postpartum
KW  - risk score
KW  - peripartal outcomes
UR  - https://www.mdpi.com/2075-1729/11/6/464
N2  - The aims of the study were (i) to find predictive factors for early postpartum conversion of gestational diabetes mellitus (GDM) into persisting glucose intolerance (PGI), (ii) to evaluate potential differences in adverse perinatal outcomes in GDM women with and without early postpartum PGI and, finally, (iii) to establish a risk score to predict postpartum PGI. A cross-sectional study comprised 244 GDM patients with known age, parity, positive family history of diabetes, pre-gestational BMI, comorbidities, smoking history, results of mid-trimester oral glucose tolerance test, HbA1c, obstetric complications, neonatal outcomes and mode of delivery. A risk score was calculated using parameters with highest odds ratios in a statistic scoring model. Significant differences between women with and without PGI postpartum were ascertained for mid-trimester fasting plasma glucose (p < 0.001), HbA1c above 42 mmol/mol (p = 0.035), prevalence of obesity (p = 0.007), hypothyroidism, family history of diabetes and smoking. We also observed higher incidence of prolonged and complicated delivery in PGI group (p = 0.04 and 0.007, respectively). In conclusion, this study identified several parameters with predictive potential for early PGI and also adverse peripartal outcomes. We established a simple risk-stratification score for PGI prediction applicable for GDM affected women prior their leaving maternity ward. Yet, given a relatively small sample size as a main limitation of this study, the proposed score should be validated in the larger cohort.
ER  -

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Lukáš PÁCAL, Veronika ŤÁPALOVÁ, Silvie SEBESTOVA, Petr JANKŮ a Kateřina KAŇKOVÁ. Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters. \textit{LIFE-BASEL}. BASEL: MDPI, 2021, roč.~11, č.~6, s.~1-10. ISSN~2075-1729. Dostupné z: https://dx.doi.org/10.3390/life11060464.

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