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@proceedings{1787360,
author = {Kročka, Erik and Galuška, David and Chalásová, Katarína and Pácal, Lukáš and Kaňková, Kateřina},
booktitle = {56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD)},
keywords = {C-peptide; glyoxalase 1 level; proximal tubular cells; in vitro},
language = {eng},
title = {C-peptide affects glyoxalase 1 level in proximal tubular cells in vitro},
url = {https://link.springer.com/article/10.1007/s00125-020-05221-5},
year = {2020}
}
TY - CONF
ID - 1787360
AU - Kročka, Erik - Galuška, David - Chalásová, Katarína - Pácal, Lukáš - Kaňková, Kateřina
PY - 2020
TI - C-peptide affects glyoxalase 1 level in proximal tubular cells in vitro
KW - C-peptide
KW - glyoxalase 1 level
KW - proximal tubular cells
KW - in vitro
UR - https://link.springer.com/article/10.1007/s00125-020-05221-5
N2 - Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease. Therapeutic strategy to prevent DKD progression involves compensation of diabetes and control of blood pressure, lipids and other metabolic parameters. However, even strict control does not have to be efficient enough. Glyoxalase system with enzyme glyoxalase I (GLO-1) is considered a protective pathway as it eliminates reactive aldehyde methylglyoxal that is involved in the development of DKD. C-peptide which has been long considered as an inert molecule, gained attention recently as it shows favourable effect on molecular and organ level in diabetes. It was shown to increase activity and expression of several antioxidants and it improved renal parameters in animal experiments. The aim of the in vitro experiment was to study the effect of C-peptide on GLO-1.
ER -
KROČKA, Erik, David GALUŠKA, Katarína CHALÁSOVÁ, Lukáš PÁCAL a Kateřina KAŇKOVÁ. C-peptide affects glyoxalase 1 level in proximal tubular cells in vitro. In \textit{56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD)}. 2020. ISSN~0012-186X.
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