The APOE4 allele is associated with a decreased risk of
retinopathy in type 2 diabetics

J 2021

The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics

DLOUHA, Lucie, Terezie PELIKANOVA, Jiri VELEBA, Vera ADAMKOVA, Vera LANSKA et. al.

Základní údaje

Originální název

The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics

Autoři

DLOUHA, Lucie (203 Česká republika), Terezie PELIKANOVA (203 Česká republika), Jiri VELEBA (203 Česká republika), Vera ADAMKOVA (203 Česká republika), Vera LANSKA (203 Česká republika), Tomas SOSNA (203 Česká republika), Lukáš PÁCAL (203 Česká republika, domácí), Kateřina KAŇKOVÁ (203 Česká republika, domácí) a Jaroslav A. HUBACEK (203 Česká republika, garant)

Vydání

MOLECULAR BIOLOGY REPORTS, DORDRECHT, Springer, 2021, 0301-4851

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.742

Kód RIV

RIV/00216224:14110/21:00120128

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s11033-021-06581-w

UT WoS

000679622300004

Klíčová slova anglicky

Retinopathy; T2DM; Apolipoprotein E; Polymorphism; Gender

Štítky

14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 1. 2022 14:43, Mgr. Tereza Miškechová

Anotace

V originále

Background Common polymorphisms within the apolipoprotein E (APOE) gene are suggested to be associated with the development of type 2 diabetes mellitus (T2DM), but the potential association with T2DM complications (nephropathy, neuropathy and retinopathy) remains unclear. We perform the case-control study to analyse the association between the APOE polymorphism and risk of T2DM and to analysed the potential relationship between the APOE and T2DM complications. Methods and results APOE variants (rs429358 and rs7412) were genotyped by TaqMan assay in T2DM patients (N = 1274; N = 829 with complications including retinopathy, neuropathy and nephropathy status) and with PCR-RFLP in healthy nondiabetic controls (N = 2055). The comparison of subjects with genotypes associated with low plasma cholesterol (APOE2/E2 and APOE2/E3 carriers vs. others) did not show an association with T2DM (OR [95% CI] = 0.88 [0.71-1.08). The differences remained insignificant after adjusting for diabetes duration, sex and BMI. Carriers of at least one APOE4 allele (rs429358) are protected against T2DM related retinopathy (OR [95% CI] = 0.65 [0.42-0.99]. Protection against retinopathy is driven mostly by females (OR [95% CI] = 0.50 [0.25-0.99]); and remains significant (P = 0.044) after adjustment for diabetes duration and BMI. Conclusion Common APOE polymorphism was not associated with T2DM in the Czech population. Yet, APOE4 allele revealed an association with retinopathy. In particular, female T2DM patients with at least one APOE4 allele exhibit lower prevalence of retinopathy in our study subjects.

Návaznosti

NV18-01-00046, projekt VaV

Název: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministerstvo zdravotnictví ČR, Genetické skóre v predikci rizika diabetu a jeho komplikací

Citovat

DLOUHA, Lucie, Terezie PELIKANOVA, Jiri VELEBA, Vera ADAMKOVA, Vera LANSKA, Tomas SOSNA, Lukáš PÁCAL, Kateřina KAŇKOVÁ a Jaroslav A. HUBACEK. The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics. MOLECULAR BIOLOGY REPORTS. DORDRECHT: Springer, 2021, roč. 48, č. 8, s. 5873-5879. ISSN 0301-4851. Dostupné z: https://dx.doi.org/10.1007/s11033-021-06581-w.

@article{1787362,
   author = {Dlouha, Lucie and Pelikanova, Terezie and Veleba, Jiri and Adamkova, Vera and Lanska, Vera and Sosna, Tomas and Pácal, Lukáš and Kaňková, Kateřina and Hubacek, Jaroslav A.},
   article_location = {DORDRECHT},
   article_number = {8},
   doi = {http://dx.doi.org/10.1007/s11033-021-06581-w},
   keywords = {Retinopathy; T2DM; Apolipoprotein E; Polymorphism; Gender},
   language = {eng},
   issn = {0301-4851},
   journal = {MOLECULAR BIOLOGY REPORTS},
   title = {The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics},
   url = {https://link.springer.com/article/10.1007%2Fs11033-021-06581-w},
   volume = {48},
   year = {2021}
}

TY  - JOUR
ID  - 1787362
AU  - Dlouha, Lucie - Pelikanova, Terezie - Veleba, Jiri - Adamkova, Vera - Lanska, Vera - Sosna, Tomas - Pácal, Lukáš - Kaňková, Kateřina - Hubacek, Jaroslav A.
PY  - 2021
TI  - The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics
JF  - MOLECULAR BIOLOGY REPORTS
VL  - 48
IS  - 8
SP  - 5873-5879
EP  - 5873-5879
PB  - Springer
SN  - 03014851
KW  - Retinopathy
KW  - T2DM
KW  - Apolipoprotein E
KW  - Polymorphism
KW  - Gender
UR  - https://link.springer.com/article/10.1007%2Fs11033-021-06581-w
N2  - Background Common polymorphisms within the apolipoprotein E (APOE) gene are suggested to be associated with the development of type 2 diabetes mellitus (T2DM), but the potential association with T2DM complications (nephropathy, neuropathy and retinopathy) remains unclear. We perform the case-control study to analyse the association between the APOE polymorphism and risk of T2DM and to analysed the potential relationship between the APOE and T2DM complications. Methods and results APOE variants (rs429358 and rs7412) were genotyped by TaqMan assay in T2DM patients (N = 1274; N = 829 with complications including retinopathy, neuropathy and nephropathy status) and with PCR-RFLP in healthy nondiabetic controls (N = 2055). The comparison of subjects with genotypes associated with low plasma cholesterol (APOE2/E2 and APOE2/E3 carriers vs. others) did not show an association with T2DM (OR [95% CI] = 0.88 [0.71-1.08). The differences remained insignificant after adjusting for diabetes duration, sex and BMI. Carriers of at least one APOE4 allele (rs429358) are protected against T2DM related retinopathy (OR [95% CI] = 0.65 [0.42-0.99]. Protection against retinopathy is driven mostly by females (OR [95% CI] = 0.50 [0.25-0.99]); and remains significant (P = 0.044) after adjustment for diabetes duration and BMI. Conclusion Common APOE polymorphism was not associated with T2DM in the Czech population. Yet, APOE4 allele revealed an association with retinopathy. In particular, female T2DM patients with at least one APOE4 allele exhibit lower prevalence of retinopathy in our study subjects.
ER  -

DLOUHA, Lucie, Terezie PELIKANOVA, Jiri VELEBA, Vera ADAMKOVA, Vera LANSKA, Tomas SOSNA, Lukáš PÁCAL, Kateřina KAŇKOVÁ a Jaroslav A. HUBACEK. The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics. \textit{MOLECULAR BIOLOGY REPORTS}. DORDRECHT: Springer, 2021, roč.~48, č.~8, s.~5873-5879. ISSN~0301-4851. Dostupné z: https://dx.doi.org/10.1007/s11033-021-06581-w.

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