2021
Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia
RIAD, Abanoub, Barbora HOCKOVÁ, Lucia KANTOROVÁ, Rastislav SLÁVIK, Lucia SPURNÁ et. al.Základní údaje
Originální název
Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia
Autoři
RIAD, Abanoub (818 Egypt, garant, domácí), Barbora HOCKOVÁ (203 Česká republika), Lucia KANTOROVÁ (703 Slovensko, domácí), Rastislav SLÁVIK (703 Slovensko), Lucia SPURNÁ (703 Slovensko), Adam STEBEL (703 Slovensko), Michal HAVRIĽAK (703 Slovensko) a Miloslav KLUGAR (203 Česká republika, domácí)
Vydání
Pharmaceuticals, Basel, MDPI, 2021, 1424-8247
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30104 Pharmacology and pharmacy
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 5.215
Kód RIV
RIV/00216224:14110/21:00122210
Organizační jednotka
Lékařská fakulta
UT WoS
000701939600001
Klíčová slova anglicky
BNT162b2 vaccine; cross-sectional studies; COVID-19; drug-related side effects and adverse reactions; health personnel; mass vaccination; prevalence
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 18. 10. 2021 09:46, Mgr. Tereza Miškechová
Anotace
V originále
mRNA-based COVID-19 vaccines such as BNT162b2 have recently been a target of anti-vaccination campaigns due to their novelty in the healthcare industry; nevertheless, these vaccines have exhibited excellent results in terms of efficacy and safety. As a consequence, they acquired the first approvals from drug regulators and were deployed at a large scale among priority groups, including healthcare workers. This phase IV study was designed as a nationwide cross-sectional survey to evaluate the post-vaccination side effects among healthcare workers in Slovakia. The study used a validated self-administered questionnaire that inquired about participants’ demographic information, medical anamneses, COVID-19-related anamnesis, and local, systemic, oral, and skin-related side effects following receiving the BNT162b2 vaccine. A total of 522 participants were included in this study, of whom 77% were females, 55.7% were aged between 31 and 54 years, and 41.6% were from Banska Bystrica. Most of the participants (91.6%) reported at least one side effect. Injection site pain (85.2%) was the most common local side effect, while fatigue (54.2%), headache (34.3%), muscle pain (28.4%), and chills (26.4%) were the most common systemic side effects. The reported side effects were of a mild nature (99.6%) that did not require medical attention and a short duration, as most of them (90.4%) were resolved within three days. Females and young adults were more likely to report post-vaccination side effects; such a finding is also consistent with what was previously reported by other phase IV studies worldwide. The role of chronic illnesses and medical treatments in post-vaccination side effect incidence and intensity requires further robust investigation among large population groups.
Návaznosti
| LTC20031, projekt VaV |
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| MUNI/A/1608/2020, interní kód MU |
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| MUNI/IGA/1068/2020, interní kód MU |
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| MUNI/IGA/1543/2020, interní kód MU |
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