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@article{1789157,
author = {Riad, Abanoub and Hocková, Barbora and Kantorová, Lucia and Slávik, Rastislav and Spurná, Lucia and Stebel, Adam and Havriľak, Michal and Klugar, Miloslav},
article_location = {Basel},
article_number = {9},
doi = {http://dx.doi.org/10.3390/ph14090873},
keywords = {BNT162b2 vaccine; cross-sectional studies; COVID-19; drug-related side effects and adverse reactions; health personnel; mass vaccination; prevalence},
language = {eng},
issn = {1424-8247},
journal = {Pharmaceuticals},
title = {Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia},
url = {https://www.mdpi.com/1424-8247/14/9/873},
volume = {14},
year = {2021}
}
TY - JOUR
ID - 1789157
AU - Riad, Abanoub - Hocková, Barbora - Kantorová, Lucia - Slávik, Rastislav - Spurná, Lucia - Stebel, Adam - Havriľak, Michal - Klugar, Miloslav
PY - 2021
TI - Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia
JF - Pharmaceuticals
VL - 14
IS - 9
SP - 1-24
EP - 1-24
PB - MDPI
SN - 14248247
KW - BNT162b2 vaccine
KW - cross-sectional studies
KW - COVID-19
KW - drug-related side effects and adverse reactions
KW - health personnel
KW - mass vaccination
KW - prevalence
UR - https://www.mdpi.com/1424-8247/14/9/873
N2 - mRNA-based COVID-19 vaccines such as BNT162b2 have recently been a target of anti-vaccination campaigns due to their novelty in the healthcare industry; nevertheless, these vaccines have exhibited excellent results in terms of efficacy and safety. As a consequence, they acquired the first approvals from drug regulators and were deployed at a large scale among priority groups, including healthcare workers. This phase IV study was designed as a nationwide cross-sectional survey to evaluate the post-vaccination side effects among healthcare workers in Slovakia. The study used a validated self-administered questionnaire that inquired about participants’ demographic information, medical anamneses, COVID-19-related anamnesis, and local, systemic, oral, and skin-related side effects following receiving the BNT162b2 vaccine. A total of 522 participants were included in this study, of whom 77% were females, 55.7% were aged between 31 and 54 years, and 41.6% were from Banska Bystrica. Most of the participants (91.6%) reported at least one side effect. Injection site pain (85.2%) was the most common local side effect, while fatigue (54.2%), headache (34.3%), muscle pain (28.4%), and chills (26.4%) were the most common systemic side effects. The reported side effects were of a mild nature (99.6%) that did not require medical attention and a short duration, as most of them (90.4%) were resolved within three days. Females and young adults were more likely to report post-vaccination side effects; such a finding is also consistent with what was previously reported by other phase IV studies worldwide. The role of chronic illnesses and medical treatments in post-vaccination side effect incidence and intensity requires further robust investigation among large population groups.
ER -
RIAD, Abanoub, Barbora HOCKOVÁ, Lucia KANTOROVÁ, Rastislav SLÁVIK, Lucia SPURNÁ, Adam STEBEL, Michal HAVRIĽAK and Miloslav KLUGAR. Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia. \textit{Pharmaceuticals}. Basel: MDPI, 2021, vol.~14, No~9, p.~1-24. ISSN~1424-8247. Available from: https://dx.doi.org/10.3390/ph14090873.
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