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@proceedings{1790350,
author = {Chareshneu, Aliaksei and Pant, Purbaj and Tristão Ramos, Ravi José and Sehnal, David and Gökbel, Tuğrul and Ionescu, CrinaandMaria and Koča, Jaroslav},
booktitle = {VIZBI 2021 - 11th international meeting on Visualizing Biological Data},
language = {eng},
title = {NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor},
url = {https://vizbi.org/Posters/2021/vA01},
year = {2021}
}
TY - CONF
ID - 1790350
AU - Chareshneu, Aliaksei - Pant, Purbaj - Tristão Ramos, Ravi José - Sehnal, David - Gökbel, Tuğrul - Ionescu, Crina-Maria - Koča, Jaroslav
PY - 2021
TI - NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor
UR - https://vizbi.org/Posters/2021/vA01
N2 - Nicotinic acetylcholine receptor (nAChR) is an ancient allosteric membrane protein mediating synaptic transmission. These prototypic pentameric ligand-gated ion channels are expressed in many tissues & species, being involved in cognition, metabolism, neuromuscular transmission, and many pathologies (myasthenia gravis, Parkinson & Alzheimer diseases, addictions). Since its isolation in 1970, studies produced >5000 publications with huge amounts of structural-functional data. However, cumulative residue-level knowledge on nAChRs is not systematically accessible. Scatteredness of literature data, aliases, various receptor types & residue numberings make it harder to summarize current knowledge and apply it efficiently to promote further discoveries. There is no single resource providing access to & visualization of such information. NACHRDB fills this gap, delivering relevant structural-functional data together with computational predictions of allosterically important residues, and facilitating its interpretation via interactive 3D visualization & sequence alignment. It can help to study allosteric regulation, reveal gaps in current knowledge, and guide further studies in the field.
ER -
CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José TRISTÃO RAMOS, David SEHNAL, Tuğrul GÖKBEL, Crina-Maria IONESCU a Jaroslav KOČA. NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor. In \textit{VIZBI 2021 - 11th international meeting on Visualizing Biological Data}. 2021.
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