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@article{1793034, author = {Tomandlová, Marie and Pařenica, Jiří and Lokaj, Petr and Ondrúš, Tomáš and Kala, Petr and Miklíková, Marie and Helánová, Kateřina and Helán, Martin and Maláska, Jan and Benešová, Klára and Jarkovský, Jiří and Pávková Goldbergová, Monika and Tomandl, Josef}, article_location = {NEW YORK}, article_number = {October 2021}, doi = {http://dx.doi.org/10.1016/j.freeradbiomed.2021.07.040}, keywords = {Cardiogenic shock; Reactive oxygen species; Oxidised guanine species; 8-Hydroxy-2 '-deoxyguanosine; Malondialdehyde; FRAP; Cu/Zn-superoxide dismutase; Glutathione peroxidase; Glutathione}, language = {eng}, issn = {0891-5849}, journal = {Free Radical Biology and Medicine}, title = {Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study}, url = {https://www.sciencedirect.com/science/article/pii/S0891584921004391?via%3Dihub}, volume = {174}, year = {2021} }
TY - JOUR ID - 1793034 AU - Tomandlová, Marie - Pařenica, Jiří - Lokaj, Petr - Ondrúš, Tomáš - Kala, Petr - Miklíková, Marie - Helánová, Kateřina - Helán, Martin - Maláska, Jan - Benešová, Klára - Jarkovský, Jiří - Pávková Goldbergová, Monika - Tomandl, Josef PY - 2021 TI - Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study JF - Free Radical Biology and Medicine VL - 174 IS - October 2021 SP - 66-72 EP - 66-72 PB - ELSEVIER SCIENCE INC SN - 08915849 KW - Cardiogenic shock KW - Reactive oxygen species KW - Oxidised guanine species KW - 8-Hydroxy-2 '-deoxyguanosine KW - Malondialdehyde KW - FRAP KW - Cu/Zn-superoxide dismutase KW - Glutathione peroxidase KW - Glutathione UR - https://www.sciencedirect.com/science/article/pii/S0891584921004391?via%3Dihub N2 - Introduction: Cardiogenic shock is a frequent complication of acute myocardial infarction. Similar to ischemia/reperfusion injury, excessive production of reactive oxygen species can be expected in those who experience cardiogenic shock. The aims of this study were to describe the extent and time course of oxidative stress and evaluate the prognostic value of oxidative stress markers in patients who experienced ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock. Methods: Plasma/serum levels of selected biomarkers of oxidative stress (oxidised guanine species (OGS), malondialdehyde, and glutathione peroxidase 3) and markers, which simultaneously reflect severe cellular damage (ferric ion reducing antioxidant power (FRAP), Cu/Zn-superoxide dismutase (SOD), and glutathione) were measured seven times per week in a prospective cohort of 82 patients with STEMI complicated by cardiogenic shock. Results: We found elevated OGS levels in patients who died during three months, which persisted significantly increased the next 12 h compared to surviving patients. A similar time course pattern also exhibited concentrations of FRAP and SOD. The other markers did not change significantly and did not show differences between surviving and non-surviving patients during the monitored period. In addition, a strong relationship between OGS, FRAP, and SOD levels (on admission and 12 h after admission) and 3-month mortality was found. Conclusion: Levels of OGS, FRAP, and SOD within 12 h after hospital admission were revealed as early predictors of the adverse development of STEMI complicated by cardiogenic shock. ER -
TOMANDLOVÁ, Marie, Jiří PAŘENICA, Petr LOKAJ, Tomáš ONDRÚŠ, Petr KALA, Marie MIKLÍKOVÁ, Kateřina HELÁNOVÁ, Martin HELÁN, Jan MALÁSKA, Klára BENEŠOVÁ, Jiří JARKOVSKÝ, Monika PÁVKOVÁ GOLDBERGOVÁ a Josef TOMANDL. Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study. \textit{Free Radical Biology and Medicine}. NEW YORK: ELSEVIER SCIENCE INC, 2021, roč.~174, October 2021, s.~66-72. ISSN~0891-5849. Dostupné z: https://dx.doi.org/10.1016/j.freeradbiomed.2021.07.040.
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