| BEZDĚKOVÁ, Renata, Tomas JELINEK, Romana KRÁLOVÁ, Martin ŠTORK, Petra POLACKOVA, Pavla VŠIANSKÁ, Lucie KUBÍNOVÁ, Jiří JARKOVSKÝ, Martina ALMÁŠI, Ivanna BOICHUK, Zdenka KNECHTOVA, Miroslav PENKA, Luděk POUR, Sabina ŠEVČÍKOVÁ, Roman HAJEK a Lucie ŘÍHOVÁ. Necessity of flow cytometry assessment of circulating plasma cells and its connection with clinical characteristics of primary and secondary plasma cell leukaemia. British journal of haematology. England: Wiley-Blackwell, 2021, roč. 195, č. 1, s. 95-107. ISSN 0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.17713. |
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@article{1793183,
author = {Bezděková, Renata and Jelinek, Tomas and Králová, Romana and Štork, Martin and Polackova, Petra and Všianská, Pavla and Kubínová, Lucie and Jarkovský, Jiří and Almáši, Martina and Boichuk, Ivanna and Knechtova, Zdenka and Penka, Miroslav and Pour, Luděk and Ševčíková, Sabina and Hajek, Roman and Říhová, Lucie},
article_location = {England},
article_number = {1},
doi = {http://dx.doi.org/10.1111/bjh.17713},
keywords = {plasma cell leukaemia; multiple myeloma; plasma cell; flow cytometry; prognosis; phenotype},
language = {eng},
issn = {0007-1048},
journal = {British journal of haematology},
title = {Necessity of flow cytometry assessment of circulating plasma cells and its connection with clinical characteristics of primary and secondary plasma cell leukaemia},
url = {https://onlinelibrary.wiley.com/doi/10.1111/bjh.17713},
volume = {195},
year = {2021}
}
TY - JOUR
ID - 1793183
AU - Bezděková, Renata - Jelinek, Tomas - Králová, Romana - Štork, Martin - Polackova, Petra - Všianská, Pavla - Kubínová, Lucie - Jarkovský, Jiří - Almáši, Martina - Boichuk, Ivanna - Knechtova, Zdenka - Penka, Miroslav - Pour, Luděk - Ševčíková, Sabina - Hajek, Roman - Říhová, Lucie
PY - 2021
TI - Necessity of flow cytometry assessment of circulating plasma cells and its connection with clinical characteristics of primary and secondary plasma cell leukaemia
JF - British journal of haematology
VL - 195
IS - 1
SP - 95-107
EP - 95-107
PB - Wiley-Blackwell
SN - 00071048
KW - plasma cell leukaemia
KW - multiple myeloma
KW - plasma cell
KW - flow cytometry
KW - prognosis
KW - phenotype
UR - https://onlinelibrary.wiley.com/doi/10.1111/bjh.17713
N2 - Plasma cell leukaemia (PCL) is a rare and very aggressive plasma cell disorder. Preventing a dismal outcome of PCL requires early diagnosis with appropriate analytical tools. Therefore, the investigation of 33 patients with primary and secondary PCL was done when the quantity of circulating plasma cells (PCs) using flow cytometry (FC) and morphology assessment was evaluated. The phenotypic profile of the PCs was also analysed to determine if there is an association with clinical outcomes and to evaluate the prognostic value of analysed markers. Our results revealed that FC is an excellent method for identifying circulating PCs as a significantly higher number was identified by FC than by morphology (26 center dot 7% vs. 13 center dot 5%, P = 0 center dot 02). None of secondary PCL cases expressed CD19 or CD20. A low level of expression with similar positivity of CD27, CD28, CD81 and CD117 was found in both PCL groups. A decrease of CD44 expression was detected only in secondary PCL. Expression of CD56 was present in more than half of PCL cases as well as cytoplasmic nestin. A decreased level of platelets, Eastern Cooperative Oncology Group score of 2-3 and lack of CD20(+) PC were associated with a higher risk of death. FC could be incorporated in PCL diagnostics not only to determine the number of circulating PCs, but also to assess their phenotype profile and this information should be useful in patients' diagnosis and possible prognosis.
ER -
BEZDĚKOVÁ, Renata, Tomas JELINEK, Romana KRÁLOVÁ, Martin ŠTORK, Petra POLACKOVA, Pavla VŠIANSKÁ, Lucie KUBÍNOVÁ, Jiří JARKOVSKÝ, Martina ALMÁŠI, Ivanna BOICHUK, Zdenka KNECHTOVA, Miroslav PENKA, Luděk POUR, Sabina ŠEVČÍKOVÁ, Roman HAJEK a Lucie ŘÍHOVÁ. Necessity of flow cytometry assessment of circulating plasma cells and its connection with clinical characteristics of primary and secondary plasma cell leukaemia. \textit{British journal of haematology}. England: Wiley-Blackwell, 2021, roč.~195, č.~1, s.~95-107. ISSN~0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.17713.
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