MARIKOVA, J., A. AL MAMUN, L. AL SHAMMARI, J. KORABECNY, T. KUCERA, D. HULCOVA, J. KUNES, Milan MALANÍK, M. VASKOVA, E. KOHELOVA, L. NOVAKOVA, L. CAHLIKOVA a M. POUR. Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids. Molecules. BASEL, SWITZERLAND: MDPI, 2021, roč. 26, č. 5, s. 1-10. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules26051279. |
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@article{1794939, author = {Marikova, J. and Al Mamun, A. and Al Shammari, L. and Korabecny, J. and Kucera, T. and Hulcova, D. and Kunes, J. and Malaník, Milan and Vaskova, M. and Kohelova, E. and Novakova, L. and Cahlikova, L. and Pour, M.}, article_location = {BASEL, SWITZERLAND}, article_number = {5}, doi = {http://dx.doi.org/10.3390/molecules26051279}, keywords = {Amaryllidaceae; 9-O-demethyllycorenine; narciabduliine; Alzheimer’ s disease}, language = {eng}, issn = {1420-3049}, journal = {Molecules}, title = {Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids}, url = {https://www.mdpi.com/1420-3049/26/5/1279}, volume = {26}, year = {2021} }
TY - JOUR ID - 1794939 AU - Marikova, J. - Al Mamun, A. - Al Shammari, L. - Korabecny, J. - Kucera, T. - Hulcova, D. - Kunes, J. - Malaník, Milan - Vaskova, M. - Kohelova, E. - Novakova, L. - Cahlikova, L. - Pour, M. PY - 2021 TI - Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids JF - Molecules VL - 26 IS - 5 SP - 1-10 EP - 1-10 PB - MDPI SN - 14203049 KW - Amaryllidaceae KW - 9-O-demethyllycorenine KW - narciabduliine KW - Alzheimer’ s disease UR - https://www.mdpi.com/1420-3049/26/5/1279 N2 - Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum x hybridum cv. Ferrari and Narcissus pseudonarcissus cv. Carlton. The chemical structures were identified by various spectroscopic (one- and two-dimensional (1D and 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) and by comparison with literature data of similar compounds. Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabduliine (2), showed balanced inhibition potency for both studied enzymes, with IC50 values of 3.29 +/- 0.73 mu M for hAChE and 3.44 +/- 0.02 mu M for hBuChE. The accommodation of 2 into the active sites of respective enzymes was predicted using molecular modeling simulation. ER -
MARIKOVA, J., A. AL MAMUN, L. AL SHAMMARI, J. KORABECNY, T. KUCERA, D. HULCOVA, J. KUNES, Milan MALANÍK, M. VASKOVA, E. KOHELOVA, L. NOVAKOVA, L. CAHLIKOVA a M. POUR. Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids. \textit{Molecules}. BASEL, SWITZERLAND: MDPI, 2021, roč.~26, č.~5, s.~1-10. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules26051279.
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