| KAUTZNER, Josef, Kristina JEDLICKOVA, Marek SRAMKO, Petr PEICHL, Jakub CVEK, Lukas KNYBEL, Radek NEUWIRTH, Otakar JIRAVSKÝ, Ludek VOSKA and Tomas KUCERA. Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia. JACC: Clinical Electrophysiology. Amsterdam: Elsevier, 2021, vol. 7, No 12, p. 1487-1492. ISSN 2405-500X. Available from: https://dx.doi.org/10.1016/j.jacep.2021.07.012. |
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@article{1795399,
author = {Kautzner, Josef and Jedlickova, Kristina and Sramko, Marek and Peichl, Petr and Cvek, Jakub and Knybel, Lukas and Neuwirth, Radek and Jiravský, Otakar and Voska, Ludek and Kucera, Tomas},
article_location = {Amsterdam},
article_number = {12},
doi = {http://dx.doi.org/10.1016/j.jacep.2021.07.012},
keywords = {catheter ablation; histology; immunohistochemistry; radiotherapy; ventricular tachycardia},
language = {eng},
issn = {2405-500X},
journal = {JACC: Clinical Electrophysiology},
title = {Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia},
url = {http://sciencedirect.com/science/article/abs/pii/S2405500X21006873?via%3Dihub#!},
volume = {7},
year = {2021}
}
TY - JOUR
ID - 1795399
AU - Kautzner, Josef - Jedlickova, Kristina - Sramko, Marek - Peichl, Petr - Cvek, Jakub - Knybel, Lukas - Neuwirth, Radek - Jiravský, Otakar - Voska, Ludek - Kucera, Tomas
PY - 2021
TI - Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia
JF - JACC: Clinical Electrophysiology
VL - 7
IS - 12
SP - 1487-1492
EP - 1487-1492
PB - Elsevier
SN - 2405500X
KW - catheter ablation
KW - histology
KW - immunohistochemistry
KW - radiotherapy
KW - ventricular tachycardia
UR - http://sciencedirect.com/science/article/abs/pii/S2405500X21006873?via%3Dihub#!
N2 - Stereotactic body radiotherapy (SBRT) has been suggested as a promising therapeutic alternative in cases of failed catheter ablation for recurrent ventricular tachycardias (VTs) in patients with structural heart disease. This case series is the first postmortem immunohistochemical analysis of morphologic changes in the myocardium early and late after SBRT. The present findings are in line with experimental observations on apoptosis followed by fibrosis. This may explain why the effect of SBRT on VT is not predominantly immediate. Together with observation of early recurrences after SBRT for VT, these data suggest that this strategy may have rather delayed antiarrhythmic effects. (J Am Coll Cardiol EP 2021;7:1487-1492) (c) 2021 by the American College of Cardiology Foundation.
ER -
KAUTZNER, Josef, Kristina JEDLICKOVA, Marek SRAMKO, Petr PEICHL, Jakub CVEK, Lukas KNYBEL, Radek NEUWIRTH, Otakar JIRAVSKÝ, Ludek VOSKA and Tomas KUCERA. Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia. \textit{JACC: Clinical Electrophysiology}. Amsterdam: Elsevier, 2021, vol.~7, No~12, p.~1487-1492. ISSN~2405-500X. Available from: https://dx.doi.org/10.1016/j.jacep.2021.07.012.
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