Cognitive impairment and depression: Meta-analysis of
structural magnetic resonance imaging studies

J 2021

Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies

ZACKOVÁ, Lenka, Martin JÁNI, Milan BRÁZDIL, Yuliya S. NIKOLOVA, Klára MAREČKOVÁ et. al.

Základní údaje

Originální název

Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies

Autoři

ZACKOVÁ, Lenka (703 Slovensko, garant, domácí), Martin JÁNI (703 Slovensko, domácí), Milan BRÁZDIL (203 Česká republika, domácí), Yuliya S. NIKOLOVA a Klára MAREČKOVÁ (203 Česká republika, domácí)

Vydání

NeuroImage: Clinical, Oxford, Elsevier BV, 2021, 2213-1582

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.891

Kód RIV

RIV/00216224:14110/21:00120148

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.nicl.2021.102830

UT WoS

000702826200006

Klíčová slova anglicky

Meta-analysis; structural magnetic resonance imaging (MRI); voxel-based morphometry (VBM); Major depressive disorder; Mild cognitive impairment; Shared volumetric reductions

Štítky

14110127, 14110222, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 2. 2022 12:05, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Longitudinal comorbidity of depression and cognitive impairment has been reported by number of epidemiological studies but the underlying mechanisms explaining the link between affective problems and cognitive decline are not very well understood. Imaging studies have typically investigated patients with major depressive disorder (MDD) and mild cognitive impairment (MCI) separately and thus have not identified a structural brain signature common to these conditions that may illuminate potentially targetable shared biological mechanisms. We performed a meta-analysis of. 48 voxel-based morphometry (VBM) studies of individuals with MDD, MCI, and age-matched controls and demonstrated that MDD and MCI patients had shared volumetric reductions in a number of regions including the insula, superior temporal gyrus (STG), inferior frontal gyrus, amygdala, hippocampus, and thalamus. We suggest that the shared volumetric reductions in the insula and STG might reflect communication deficits and infrequent participation in mentally or socially stimulating activities, which have been described as risk factors for both MCI and MDD. We also suggest that the disease-specific structural changes might reflect the disease-specific symptoms such as poor integration of emotional information, feelings of helplessness and worthlessness, and anhedonia in MDD. These findings could contribute to better understanding of the origins of MDD-MCI comorbidity and facilitate development of early interventions.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NU20J-04-00022, projekt VaV

Název: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministerstvo zdravotnictví ČR, Zdravé stárnutí mozku: Celoživotní perspektiva, Podprogram 2 - juniorský - výzkumníci do 35 let

Citovat

ZACKOVÁ, Lenka, Martin JÁNI, Milan BRÁZDIL, Yuliya S. NIKOLOVA a Klára MAREČKOVÁ. Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies. NeuroImage: Clinical. Oxford: Elsevier BV, 2021, roč. 32, č. 2021, s. 1-10. ISSN 2213-1582. Dostupné z: https://dx.doi.org/10.1016/j.nicl.2021.102830.

@article{1798280,
   author = {Zacková, Lenka and Jáni, Martin and Brázdil, Milan and Nikolova, Yuliya S. and Marečková, Klára},
   article_location = {Oxford},
   article_number = {2021},
   doi = {http://dx.doi.org/10.1016/j.nicl.2021.102830},
   keywords = {Meta-analysis; structural magnetic resonance imaging (MRI); voxel-based morphometry (VBM); Major depressive disorder; Mild cognitive impairment; Shared volumetric reductions},
   language = {eng},
   issn = {2213-1582},
   journal = {NeuroImage: Clinical},
   title = {Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies},
   url = {https://www.sciencedirect.com/science/article/pii/S2213158221002746?via%3Dihub},
   volume = {32},
   year = {2021}
}

TY  - JOUR
ID  - 1798280
AU  - Zacková, Lenka - Jáni, Martin - Brázdil, Milan - Nikolova, Yuliya S. - Marečková, Klára
PY  - 2021
TI  - Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies
JF  - NeuroImage: Clinical
VL  - 32
IS  - 2021
SP  - 1-10
EP  - 1-10
PB  - Elsevier BV
SN  - 22131582
KW  - Meta-analysis
KW  - structural magnetic resonance imaging (MRI)
KW  - voxel-based morphometry (VBM)
KW  - Major depressive disorder
KW  - Mild cognitive impairment
KW  - Shared volumetric reductions
UR  - https://www.sciencedirect.com/science/article/pii/S2213158221002746?via%3Dihub
N2  - Longitudinal comorbidity of depression and cognitive impairment has been reported by number of epidemiological studies but the underlying mechanisms explaining the link between affective problems and cognitive decline are not very well understood. Imaging studies have typically investigated patients with major depressive disorder (MDD) and mild cognitive impairment (MCI) separately and thus have not identified a structural brain signature common to these conditions that may illuminate potentially targetable shared biological mechanisms. We performed a meta-analysis of. 48 voxel-based morphometry (VBM) studies of individuals with MDD, MCI, and age-matched controls and demonstrated that MDD and MCI patients had shared volumetric reductions in a number of regions including the insula, superior temporal gyrus (STG), inferior frontal gyrus, amygdala, hippocampus, and thalamus. We suggest that the shared volumetric reductions in the insula and STG might reflect communication deficits and infrequent participation in mentally or socially stimulating activities, which have been described as risk factors for both MCI and MDD. We also suggest that the disease-specific structural changes might reflect the disease-specific symptoms such as poor integration of emotional information, feelings of helplessness and worthlessness, and anhedonia in MDD. These findings could contribute to better understanding of the origins of MDD-MCI comorbidity and facilitate development of early interventions.
ER  -

ZACKOVÁ, Lenka, Martin JÁNI, Milan BRÁZDIL, Yuliya S. NIKOLOVA a Klára MAREČKOVÁ. Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies. \textit{NeuroImage: Clinical}. Oxford: Elsevier BV, 2021, roč.~32, č.~2021, s.~1-10. ISSN~2213-1582. Dostupné z: https://dx.doi.org/10.1016/j.nicl.2021.102830.

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