Decreased immune response after PASylation of stealth ferritin nanocarriers

TESAROVA, B, H POLANSKA, V SMIDOVA a Zita GOLIÁŠOVÁ. Decreased immune response after PASylation of stealth ferritin nanocarriers. In MENDELNET 2019: PROCEEDINGS OF 26TH INTERNATIONAL PHD STUDENTS CONFERENCE. 2019. ISBN 978-80-7509-688-3.

Základní údaje

Originální název

Decreased immune response after PASylation of stealth ferritin nanocarriers

Autoři

TESAROVA, B, H POLANSKA, V SMIDOVA a Zita GOLIÁŠOVÁ

Vydání

MENDELNET 2019: PROCEEDINGS OF 26TH INTERNATIONAL PHD STUDENTS CONFERENCE, 2019

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Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Utajení

není předmětem státního či obchodního tajemství

ISBN

978-80-7509-688-3

UT WoS

000576735500121

Klíčová slova anglicky

apoferritin; immune response; nanomedicine; PASylation

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Anotace

V originále

The effects on immunocompatibility after performed surface modifications (PEGylation and PASylation) of natural nanocarriers based on ferritin (FRT) were tested in this work. Potential cytostatic drug ellipticine (Elli) was encapsulated into FRT, leading to formation of FRTElli. The main goals of prepared PEG-FRTElli, PAS-10-FRTElli and PAS-20-FRTElli were to achieve decreased in vitro macrophage uptake and decreased in vivo complement activation. Macrophage uptake was studied via flow cytometry and complement activation via western blot. According to performed experiments PAS-10 modification was the only one that was sufficient to ensure both aspects.