COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)
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PAGANO, L. (garant), J. SALMANTON-GARCIA, F. MARCHESI, A. BUSCA, P. CORRADINI, M. HOENIGL, N. KLIMKO, P. KOEHLER, A. PAGLIUCA, F. PASSAMONTI, L. VERGA, B. VISEK, O. ILHAN, G. NADALI, Barbora WEINBERGEROVÁ (203 Česká republika, domácí), R. CORDOBA-MASCUNANO, M. MARCHETTI, G. P. COLLINS, F. FARINA, C. CATTANEO, A. CABIRTA, M. GOMES-SILVA, F. ITRI, J. VAN DOESUM, M. P. LEDOUX, M. CERNAN, O. JAKSIC, R. F. DUARTE, G. MAGLIANO, A. S. OMRANI, N. S. FRACCHIOLLA, A. KULASEKARARAJ, T. VALKOVIC, C. B. POULSEN, M. MACHADO, A. GLENTHOJ, I. STOMA, Zdenek RACIL (203 Česká republika), K. PIUKOVICS, Milan NAVRATIL, Z. EMARAH, U. SILI, J. MAERTENS, O. BLENNOW, R. BERGANTIM, C. GARCIA-VIDAL, L. PREZIOSO, A. GUIDETTI, M. I. DEL PRINCIPE, M. POPOVA, N. DE JONGE, I. ORMAZABAL-VELEZ, N. FERNANDEZ, I. FALCES-ROMERO, A. CUCCARO, S. MEERS, C. BUQUICCHIO, D. ANTIC, M. AL-KHABORI, R. GARCIA-SANZ, M. M. BIERNAT, M. C. TISI, E. SAL, L. RAHIMLI, N. COLOVIC, M. SCHONLEIN, M. CALBACHO, C. TASCINI, C. MIRANDA-CASTILLO, N. KHANNA, G. A. MENDEZ, V. PETZER, J. NOVAK, C. BESSON, R. DULERY, S. LAMURE, M. NUCCI, G. ZAMBROTTA, Pavel ZAK (203 Česká republika), G. C. SEVAL, V. BONUOMO, Jiří MAYER (203 Česká republika, domácí), A. LOPEZ-GARCIA, M. V. SACCHI, S. BOOTH, F. CICERI, M. OBERTI, M. SALVINI, M. IZUZQUIZA, R. NUNES-RODRIGUES, E. AMMATUNA, Ales OBR (203 Česká republika), R. HERBRECHT, L. NUNEZ-MARTIN-BUITRAGO, V. MANCINI, H. SHWAYLIA, M. SCIUME, J. ESSAME, M. NYGAARD, J. BATINIC, Y. GONZAGA, I. REGALADO-ARTAMENDI, L. K. KARLSSON, M. SHAPETSKA, Michaela HANAKOVA (203 Česká republika), S. EL-ASHWAH, Z. BORBENYI, G. M. COLAK, A. NORDLANDER, G. DRAGONETTI, A. M. E. MARAGLINO, A. RINALDI, C. DE RAMON-SANCHEZ a O. A. CORNELY
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JOURNAL OF HEMATOLOGY & ONCOLOGY, LONDON, BMC, 2021, 1756-8722
Background Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.
Návaznosti
2015-1-CZ01-KA203-013935, interní kód MU
Název: Medical Curriculum Innovations (Akronym: MEDCIN)
Investor: Evropská unie, Medical Curriculum Innovations, Strategická partnerství v oblasti vzdělávání, odborné přípravy a mládeže
PAGANO, L., J. SALMANTON-GARCIA, F. MARCHESI, A. BUSCA, P. CORRADINI, M. HOENIGL, N. KLIMKO, P. KOEHLER, A. PAGLIUCA, F. PASSAMONTI, L. VERGA, B. VISEK, O. ILHAN, G. NADALI, Barbora WEINBERGEROVÁ, R. CORDOBA-MASCUNANO, M. MARCHETTI, G. P. COLLINS, F. FARINA, C. CATTANEO, A. CABIRTA, M. GOMES-SILVA, F. ITRI, J. VAN DOESUM, M. P. LEDOUX, M. CERNAN, O. JAKSIC, R. F. DUARTE, G. MAGLIANO, A. S. OMRANI, N. S. FRACCHIOLLA, A. KULASEKARARAJ, T. VALKOVIC, C. B. POULSEN, M. MACHADO, A. GLENTHOJ, I. STOMA, Zdenek RACIL, K. PIUKOVICS, Milan NAVRATIL, Z. EMARAH, U. SILI, J. MAERTENS, O. BLENNOW, R. BERGANTIM, C. GARCIA-VIDAL, L. PREZIOSO, A. GUIDETTI, M. I. DEL PRINCIPE, M. POPOVA, N. DE JONGE, I. ORMAZABAL-VELEZ, N. FERNANDEZ, I. FALCES-ROMERO, A. CUCCARO, S. MEERS, C. BUQUICCHIO, D. ANTIC, M. AL-KHABORI, R. GARCIA-SANZ, M. M. BIERNAT, M. C. TISI, E. SAL, L. RAHIMLI, N. COLOVIC, M. SCHONLEIN, M. CALBACHO, C. TASCINI, C. MIRANDA-CASTILLO, N. KHANNA, G. A. MENDEZ, V. PETZER, J. NOVAK, C. BESSON, R. DULERY, S. LAMURE, M. NUCCI, G. ZAMBROTTA, Pavel ZAK, G. C. SEVAL, V. BONUOMO, Jiří MAYER, A. LOPEZ-GARCIA, M. V. SACCHI, S. BOOTH, F. CICERI, M. OBERTI, M. SALVINI, M. IZUZQUIZA, R. NUNES-RODRIGUES, E. AMMATUNA, Ales OBR, R. HERBRECHT, L. NUNEZ-MARTIN-BUITRAGO, V. MANCINI, H. SHWAYLIA, M. SCIUME, J. ESSAME, M. NYGAARD, J. BATINIC, Y. GONZAGA, I. REGALADO-ARTAMENDI, L. K. KARLSSON, M. SHAPETSKA, Michaela HANAKOVA, S. EL-ASHWAH, Z. BORBENYI, G. M. COLAK, A. NORDLANDER, G. DRAGONETTI, A. M. E. MARAGLINO, A. RINALDI, C. DE RAMON-SANCHEZ a O. A. CORNELY. COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). JOURNAL OF HEMATOLOGY & ONCOLOGY. LONDON: BMC, 2021, roč. 14, č. 1, s. 1-15. ISSN 1756-8722. Dostupné z: https://dx.doi.org/10.1186/s13045-021-01177-0.
@article{1801283, author = {Pagano, L. and SalmantonandGarcia, J. and Marchesi, F. and Busca, A. and Corradini, P. and Hoenigl, M. and Klimko, N. and Koehler, P. and Pagliuca, A. and Passamonti, F. and Verga, L. and Visek, B. and Ilhan, O. and Nadali, G. and Weinbergerová, Barbora and CordobaandMascunano, R. and Marchetti, M. and Collins, G. P. and Farina, F. and Cattaneo, C. and Cabirta, A. and GomesandSilva, M. and Itri, F. and van Doesum, J. and Ledoux, M. P. and Cernan, M. and Jaksic, O. and Duarte, R. F. and Magliano, G. and Omrani, A. S. and Fracchiolla, N. S. and Kulasekararaj, A. and Valkovic, T. and Poulsen, C. B. and Machado, M. and Glenthoj, A. and Stoma, I. and Racil, Zdenek and Piukovics, K. and Navratil, Milan and Emarah, Z. and Sili, U. and Maertens, J. and Blennow, O. and Bergantim, R. and GarciaandVidal, C. and Prezioso, L. and Guidetti, A. and del Principe, M. I. and Popova, M. and de Jonge, N. and OrmazabalandVelez, I. and Fernandez, N. and FalcesandRomero, I. and Cuccaro, A. and Meers, S. and Buquicchio, C. and Antic, D. and AlandKhabori, M. and GarciaandSanz, R. and Biernat, M. M. and Tisi, M. C. and Sal, E. and Rahimli, L. and Colovic, N. and Schonlein, M. and Calbacho, M. and Tascini, C. and MirandaandCastillo, C. and Khanna, N. and Mendez, G. A. and Petzer, V. and Novak, J. and Besson, C. and Dulery, R. and Lamure, S. and Nucci, M. and Zambrotta, G. and Zak, Pavel and Seval, G. C. and Bonuomo, V. and Mayer, Jiří and LopezandGarcia, A. and Sacchi, M. V. and Booth, S. and Ciceri, F. and Oberti, M. and Salvini, M. and Izuzquiza, M. and NunesandRodrigues, R. and Ammatuna, E. and Obr, Ales and Herbrecht, R. and NunezandMartinandBuitrago, L. and Mancini, V. and Shwaylia, H. and Sciume, M. and Essame, J. and Nygaard, M. and Batinic, J. and Gonzaga, Y. and RegaladoandArtamendi, I. and Karlsson, L. K. and Shapetska, M. and Hanakova, Michaela and ElandAshwah, S. and Borbenyi, Z. and Colak, G. M. and Nordlander, A. and Dragonetti, G. and Maraglino, A. M. E. and Rinaldi, A. and De RamonandSanchez, C. and Cornely, O. A.}, article_location = {LONDON}, article_number = {1}, doi = {http://dx.doi.org/10.1186/s13045-021-01177-0}, keywords = {COVID-19; Pandemic; Hematological malignancies; Epidemiology; EHA}, language = {eng}, issn = {1756-8722}, journal = {JOURNAL OF HEMATOLOGY & ONCOLOGY}, title = {COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)}, url = {https://jhoonline.biomedcentral.com/articles/10.1186/s13045-021-01177-0}, volume = {14}, year = {2021} }
TY - JOUR ID - 1801283 AU - Pagano, L. - Salmanton-Garcia, J. - Marchesi, F. - Busca, A. - Corradini, P. - Hoenigl, M. - Klimko, N. - Koehler, P. - Pagliuca, A. - Passamonti, F. - Verga, L. - Visek, B. - Ilhan, O. - Nadali, G. - Weinbergerová, Barbora - Cordoba-Mascunano, R. - Marchetti, M. - Collins, G. P. - Farina, F. - Cattaneo, C. - Cabirta, A. - Gomes-Silva, M. - Itri, F. - van Doesum, J. - Ledoux, M. P. - Cernan, M. - Jaksic, O. - Duarte, R. F. - Magliano, G. - Omrani, A. S. - Fracchiolla, N. S. - Kulasekararaj, A. - Valkovic, T. - Poulsen, C. B. - Machado, M. - Glenthoj, A. - Stoma, I. - Racil, Zdenek - Piukovics, K. - Navratil, Milan - Emarah, Z. - Sili, U. - Maertens, J. - Blennow, O. - Bergantim, R. - Garcia-Vidal, C. - Prezioso, L. - Guidetti, A. - del Principe, M. I. - Popova, M. - de Jonge, N. - Ormazabal-Velez, I. - Fernandez, N. - Falces-Romero, I. - Cuccaro, A. - Meers, S. - Buquicchio, C. - Antic, D. - Al-Khabori, M. - Garcia-Sanz, R. - Biernat, M. M. - Tisi, M. C. - Sal, E. - Rahimli, L. - Colovic, N. - Schonlein, M. - Calbacho, M. - Tascini, C. - Miranda-Castillo, C. - Khanna, N. - Mendez, G. A. - Petzer, V. - Novak, J. - Besson, C. - Dulery, R. - Lamure, S. - Nucci, M. - Zambrotta, G. - Zak, Pavel - Seval, G. C. - Bonuomo, V. - Mayer, Jiří - Lopez-Garcia, A. - Sacchi, M. V. - Booth, S. - Ciceri, F. - Oberti, M. - Salvini, M. - Izuzquiza, M. - Nunes-Rodrigues, R. - Ammatuna, E. - Obr, Ales - Herbrecht, R. - Nunez-Martin-Buitrago, L. - Mancini, V. - Shwaylia, H. - Sciume, M. - Essame, J. - Nygaard, M. - Batinic, J. - Gonzaga, Y. - Regalado-Artamendi, I. - Karlsson, L. K. - Shapetska, M. - Hanakova, Michaela - El-Ashwah, S. - Borbenyi, Z. - Colak, G. M. - Nordlander, A. - Dragonetti, G. - Maraglino, A. M. E. - Rinaldi, A. - De Ramon-Sanchez, C. - Cornely, O. A. PY - 2021 TI - COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA) JF - JOURNAL OF HEMATOLOGY & ONCOLOGY VL - 14 IS - 1 SP - 1-15 EP - 1-15 PB - BMC SN - 17568722 KW - COVID-19 KW - Pandemic KW - Hematological malignancies KW - Epidemiology KW - EHA UR - https://jhoonline.biomedcentral.com/articles/10.1186/s13045-021-01177-0 N2 - Background Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases. ER -
PAGANO, L., J. SALMANTON-GARCIA, F. MARCHESI, A. BUSCA, P. CORRADINI, M. HOENIGL, N. KLIMKO, P. KOEHLER, A. PAGLIUCA, F. PASSAMONTI, L. VERGA, B. VISEK, O. ILHAN, G. NADALI, Barbora WEINBERGEROVÁ, R. CORDOBA-MASCUNANO, M. MARCHETTI, G. P. COLLINS, F. FARINA, C. CATTANEO, A. CABIRTA, M. GOMES-SILVA, F. ITRI, J. VAN DOESUM, M. P. LEDOUX, M. CERNAN, O. JAKSIC, R. F. DUARTE, G. MAGLIANO, A. S. OMRANI, N. S. FRACCHIOLLA, A. KULASEKARARAJ, T. VALKOVIC, C. B. POULSEN, M. MACHADO, A. GLENTHOJ, I. STOMA, Zdenek RACIL, K. PIUKOVICS, Milan NAVRATIL, Z. EMARAH, U. SILI, J. MAERTENS, O. BLENNOW, R. BERGANTIM, C. GARCIA-VIDAL, L. PREZIOSO, A. GUIDETTI, M. I. DEL PRINCIPE, M. POPOVA, N. DE JONGE, I. ORMAZABAL-VELEZ, N. FERNANDEZ, I. FALCES-ROMERO, A. CUCCARO, S. MEERS, C. BUQUICCHIO, D. ANTIC, M. AL-KHABORI, R. GARCIA-SANZ, M. M. BIERNAT, M. C. TISI, E. SAL, L. RAHIMLI, N. COLOVIC, M. SCHONLEIN, M. CALBACHO, C. TASCINI, C. MIRANDA-CASTILLO, N. KHANNA, G. A. MENDEZ, V. PETZER, J. NOVAK, C. BESSON, R. DULERY, S. LAMURE, M. NUCCI, G. ZAMBROTTA, Pavel ZAK, G. C. SEVAL, V. BONUOMO, Jiří MAYER, A. LOPEZ-GARCIA, M. V. SACCHI, S. BOOTH, F. CICERI, M. OBERTI, M. SALVINI, M. IZUZQUIZA, R. NUNES-RODRIGUES, E. AMMATUNA, Ales OBR, R. HERBRECHT, L. NUNEZ-MARTIN-BUITRAGO, V. MANCINI, H. SHWAYLIA, M. SCIUME, J. ESSAME, M. NYGAARD, J. BATINIC, Y. GONZAGA, I. REGALADO-ARTAMENDI, L. K. KARLSSON, M. SHAPETSKA, Michaela HANAKOVA, S. EL-ASHWAH, Z. BORBENYI, G. M. COLAK, A. NORDLANDER, G. DRAGONETTI, A. M. E. MARAGLINO, A. RINALDI, C. DE RAMON-SANCHEZ a O. A. CORNELY. COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). \textit{JOURNAL OF HEMATOLOGY \&{} ONCOLOGY}. LONDON: BMC, 2021, roč.~14, č.~1, s.~1-15. ISSN~1756-8722. Dostupné z: https://dx.doi.org/10.1186/s13045-021-01177-0.