SOJKA, Martin, Jan CHYBA, Shib Shankar PAUL, Karolina WAWROCKA, Kateřina HÖNIGOVÁ, Ben Joseph Rubiato CUYACOT, Abril Carolina Castro AGUILERA, Tomáš VACULOVIČ, Jaromír MAREK, Michal REPISKY, Michal MASAŘÍK, Jan NOVOTNÝ a Radek MAREK. Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects. Inorganic Chemistry. Washington: American Chemical Society, 2021, roč. 60, č. 23, s. 17911-17925. ISSN 0020-1669. Dostupné z: https://dx.doi.org/10.1021/acs.inorgchem.1c02467. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1801348, author = {Sojka, Martin and Chyba, Jan and Paul, Shib Shankar and Wawrocka, Karolina and Hönigová, Kateřina and Cuyacot, Ben Joseph Rubiato and Aguilera, Abril Carolina Castro and Vaculovič, Tomáš and Marek, Jaromír and Repisky, Michal and Masařík, Michal and Novotný, Jan and Marek, Radek}, article_location = {Washington}, article_number = {23}, doi = {http://dx.doi.org/10.1021/acs.inorgchem.1c02467}, keywords = {metallodrug; supramolecule; host-guest complex; platinum; NMR; chemical shift; relativistic DFT; cytotoxicity; drug uptake}, language = {eng}, issn = {0020-1669}, journal = {Inorganic Chemistry}, title = {Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects}, url = {https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c02467}, volume = {60}, year = {2021} }
TY - JOUR ID - 1801348 AU - Sojka, Martin - Chyba, Jan - Paul, Shib Shankar - Wawrocka, Karolina - Hönigová, Kateřina - Cuyacot, Ben Joseph Rubiato - Aguilera, Abril Carolina Castro - Vaculovič, Tomáš - Marek, Jaromír - Repisky, Michal - Masařík, Michal - Novotný, Jan - Marek, Radek PY - 2021 TI - Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects JF - Inorganic Chemistry VL - 60 IS - 23 SP - 17911-17925 EP - 17911-17925 PB - American Chemical Society SN - 00201669 KW - metallodrug KW - supramolecule KW - host-guest complex KW - platinum KW - NMR KW - chemical shift KW - relativistic DFT KW - cytotoxicity KW - drug uptake UR - https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c02467 N2 - Platinum-based anticancer drugs are actively developed utilizing lipophilic ligands or drug carriers for the efficient penetration of biomembranes, reduction of side effects, and tumor targeting. We report the development of a supramolecular host–guest system built on cationic platinum(II) compounds bearing ligands anchored in the cavity of the macrocyclic host. The host–guest binding and hydrolysis process on the platinum core were investigated in detail by using NMR, MS, X-ray diffraction, and relativistic DFT calculations. The encapsulation process in cucurbit[7]uril unequivocally promotes the stability of hydrolyzed dicationic cis-[PtII(NH3)2(H2O)(NH2-R)]2+ compared to its trans isomer. Biological screening on the ovarian cancer lines A2780 and A2780/CP shows time-dependent toxicity. Notably, the reported complex and its β-cyclodextrin (β-CD) assembly achieve the same cellular uptake as cisplatin and cisplatin@β-CD, respectively, while maintaining a significantly lower toxicity profile. ER -
SOJKA, Martin, Jan CHYBA, Shib Shankar PAUL, Karolina WAWROCKA, Kateřina HÖNIGOVÁ, Ben Joseph Rubiato CUYACOT, Abril Carolina Castro AGUILERA, Tomáš VACULOVIČ, Jaromír MAREK, Michal REPISKY, Michal MASAŘÍK, Jan NOVOTNÝ a Radek MAREK. Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects. \textit{Inorganic Chemistry}. Washington: American Chemical Society, 2021, roč.~60, č.~23, s.~17911-17925. ISSN~0020-1669. Dostupné z: https://dx.doi.org/10.1021/acs.inorgchem.1c02467.
|