| SOJKA, Martin, Jan CHYBA, Shib Shankar PAUL, Karolina WAWROCKA, Kateřina HÖNIGOVÁ, Ben Joseph Rubiato CUYACOT, Abril Carolina Castro AGUILERA, Tomáš VACULOVIČ, Jaromír MAREK, Michal REPISKY, Michal MASAŘÍK, Jan NOVOTNÝ a Radek MAREK. Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects. Inorganic Chemistry. Washington: American Chemical Society, 2021, roč. 60, č. 23, s. 17911-17925. ISSN 0020-1669. Dostupné z: https://dx.doi.org/10.1021/acs.inorgchem.1c02467. |
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@article{1801348,
author = {Sojka, Martin and Chyba, Jan and Paul, Shib Shankar and Wawrocka, Karolina and Hönigová, Kateřina and Cuyacot, Ben Joseph Rubiato and Aguilera, Abril Carolina Castro and Vaculovič, Tomáš and Marek, Jaromír and Repisky, Michal and Masařík, Michal and Novotný, Jan and Marek, Radek},
article_location = {Washington},
article_number = {23},
doi = {http://dx.doi.org/10.1021/acs.inorgchem.1c02467},
keywords = {metallodrug; supramolecule; host-guest complex; platinum; NMR; chemical shift; relativistic DFT; cytotoxicity; drug uptake},
language = {eng},
issn = {0020-1669},
journal = {Inorganic Chemistry},
title = {Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects},
url = {https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c02467},
volume = {60},
year = {2021}
}
TY - JOUR
ID - 1801348
AU - Sojka, Martin - Chyba, Jan - Paul, Shib Shankar - Wawrocka, Karolina - Hönigová, Kateřina - Cuyacot, Ben Joseph Rubiato - Aguilera, Abril Carolina Castro - Vaculovič, Tomáš - Marek, Jaromír - Repisky, Michal - Masařík, Michal - Novotný, Jan - Marek, Radek
PY - 2021
TI - Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects
JF - Inorganic Chemistry
VL - 60
IS - 23
SP - 17911-17925
EP - 17911-17925
PB - American Chemical Society
SN - 00201669
KW - metallodrug
KW - supramolecule
KW - host-guest complex
KW - platinum
KW - NMR
KW - chemical shift
KW - relativistic DFT
KW - cytotoxicity
KW - drug uptake
UR - https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c02467
N2 - Platinum-based anticancer drugs are actively developed utilizing lipophilic ligands or drug carriers for the efficient penetration of biomembranes, reduction of side effects, and tumor targeting. We report the development of a supramolecular host–guest system built on cationic platinum(II) compounds bearing ligands anchored in the cavity of the macrocyclic host. The host–guest binding and hydrolysis process on the platinum core were investigated in detail by using NMR, MS, X-ray diffraction, and relativistic DFT calculations. The encapsulation process in cucurbit[7]uril unequivocally promotes the stability of hydrolyzed dicationic cis-[PtII(NH3)2(H2O)(NH2-R)]2+ compared to its trans isomer. Biological screening on the ovarian cancer lines A2780 and A2780/CP shows time-dependent toxicity. Notably, the reported complex and its β-cyclodextrin (β-CD) assembly achieve the same cellular uptake as cisplatin and cisplatin@β-CD, respectively, while maintaining a significantly lower toxicity profile.
ER -
SOJKA, Martin, Jan CHYBA, Shib Shankar PAUL, Karolina WAWROCKA, Kateřina HÖNIGOVÁ, Ben Joseph Rubiato CUYACOT, Abril Carolina Castro AGUILERA, Tomáš VACULOVIČ, Jaromír MAREK, Michal REPISKY, Michal MASAŘÍK, Jan NOVOTNÝ a Radek MAREK. Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects. \textit{Inorganic Chemistry}. Washington: American Chemical Society, 2021, roč.~60, č.~23, s.~17911-17925. ISSN~0020-1669. Dostupné z: https://dx.doi.org/10.1021/acs.inorgchem.1c02467.
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