Adolopment of guideline on diabetic foot ulcers: an umbrella
review with de novo meta-analyses of randomized controlled
trials for autologous cell therapy in no-option chronic
limb-threatening ischemia

k 2021

Adolopment of guideline on diabetic foot ulcers: an umbrella review with de novo meta-analyses of randomized controlled trials for autologous cell therapy in no-option chronic limb-threatening ischemia

KANTOROVÁ, Lucia, Tereza VRBOVÁ, Andrea POKORNÁ, Jitka KLUGAROVÁ, Miloslav KLUGAR et. al.

Základní údaje

Originální název

Adolopment of guideline on diabetic foot ulcers: an umbrella review with de novo meta-analyses of randomized controlled trials for autologous cell therapy in no-option chronic limb-threatening ischemia

Autoři

KANTOROVÁ, Lucia (703 Slovensko, domácí), Tereza VRBOVÁ (203 Česká republika, domácí), Andrea POKORNÁ (203 Česká republika, domácí), Jitka KLUGAROVÁ (203 Česká republika, domácí) a Miloslav KLUGAR (203 Česká republika, domácí)

Vydání

GIN Conference 2021, 2021

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/21:00122796

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

diabetic foot ulcers; autologous cell therapy; umbrella review

Změněno: 25. 11. 2021 11:32, Mgr. Bc. Alena Langaufová, Ph.D.

Anotace

V originále

Background One of the approved guidelines by the Czech Health Research Council in the Project Clinical Practice Guidelines is focused on the issue of Diabetic foot ulcers (DFU). We identified several existing high-quality guidelines for adaptation; however, none addressed the question of proper use of autologous cell therapy (ACT) optimally. Objective This work presents methods and results of an umbrella systematic review following the JBI methodology to evaluate the effectiveness and safety of ACT in no-option critical limb-threatening ischemia (CLTI) for the DFU guideline adolopment process. Methods To keep up with the highest methodological standards and choose a feasible solution, we first searched 12 electronic sources via Epistemonikos in January 2021. We identified 19 systematic reviews (SR) of various quality and conflicting findings. We used the PRISMA guidelines and an a priori published protocol. To get conclusive answers, we decided to extract primary study results from the eligible SRs and undertake de novo meta-analyses, with detailed sensitivity and subgroup analyses, as discussed with clinical experts. We carried out a GRADE assessment of the certainty of evidence. Results We found 20 RCTs with 1140 participants in the SRs to be eligible for this review and the guideline under preparation. We assessed mortality, healed ulcers, major amputations, amputation-free survival, rest pain, and ischemic parameters. Discussion ACT likely improves healing, reduces amputations, alleviates pain, and may lead to a slight increase in the ankle-brachial index and transcutaneous oxygen pressure in CLTI patients.

Návaznosti

MUNI/IGA/1068/2020, interní kód MU

Název: Methodological and practical aspects of the development of guidelines and rapid guidelines in public health (Akronym: RAPguidelines-public-health)

Investor: Masarykova univerzita, Methodological and practical aspects of the development of guidelines and rapid guidelines in public health

Citovat

KANTOROVÁ, Lucia, Tereza VRBOVÁ, Andrea POKORNÁ, Jitka KLUGAROVÁ a Miloslav KLUGAR. Adolopment of guideline on diabetic foot ulcers: an umbrella review with de novo meta-analyses of randomized controlled trials for autologous cell therapy in no-option chronic limb-threatening ischemia. In GIN Conference 2021. 2021.

@proceedings{1802264,
   author = {Kantorová, Lucia and Vrbová, Tereza and Pokorná, Andrea and Klugarová, Jitka and Klugar, Miloslav},
   booktitle = {GIN Conference 2021},
   keywords = {diabetic foot ulcers; autologous cell therapy; umbrella review},
   language = {eng},
   title = {Adolopment of guideline on diabetic foot ulcers: an umbrella review with de novo meta-analyses of randomized controlled trials for autologous cell therapy in no-option chronic limb-threatening ischemia},
   year = {2021}
}

TY  - CONF
ID  - 1802264
AU  - Kantorová, Lucia - Vrbová, Tereza - Pokorná, Andrea - Klugarová, Jitka - Klugar, Miloslav
PY  - 2021
TI  - Adolopment of guideline on diabetic foot ulcers: an umbrella review with de novo meta-analyses of randomized controlled trials for autologous cell therapy in no-option chronic limb-threatening ischemia
KW  - diabetic foot ulcers
KW  - autologous cell therapy
KW  - umbrella review
N2  - Background One of the approved guidelines by the Czech Health Research Council in the Project Clinical Practice Guidelines is focused on the issue of Diabetic foot ulcers (DFU). We identified several existing high-quality guidelines for adaptation; however, none addressed the question of proper use of autologous cell therapy (ACT) optimally. Objective This work presents methods and results of an umbrella systematic review following the JBI methodology to evaluate the effectiveness and safety of ACT in no-option critical limb-threatening ischemia (CLTI) for the DFU guideline adolopment process. Methods To keep up with the highest methodological standards and choose a feasible solution, we first searched 12 electronic sources via Epistemonikos in January 2021. We identified 19 systematic reviews (SR) of various quality and conflicting findings. We used the PRISMA guidelines and an a priori published protocol. To get conclusive answers, we decided to extract primary study results from the eligible SRs and undertake de novo meta-analyses, with detailed sensitivity and subgroup analyses, as discussed with clinical experts. We carried out a GRADE assessment of the certainty of evidence. Results We found 20 RCTs with 1140 participants in the SRs to be eligible for this review and the guideline under preparation. We assessed mortality, healed ulcers, major amputations, amputation-free survival, rest pain, and ischemic parameters. Discussion ACT likely improves healing, reduces amputations, alleviates pain, and may lead to a slight increase in the ankle-brachial index and transcutaneous oxygen pressure in CLTI patients.
ER  -

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