The Aging Muscle in Experimental Bed Rest: A Systematic Review
and Meta-Analysis

J 2021

The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis

DI GIROLAMO, Filippo Giorgio, Nicola FIOTTI, Zoran MILANOVIC, Roberta SITULIN, Filippo MEARELLI et. al.

Základní údaje

Originální název

The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis

Autoři

DI GIROLAMO, Filippo Giorgio (380 Itálie), Nicola FIOTTI (380 Itálie), Zoran MILANOVIC (688 Srbsko, garant, domácí), Roberta SITULIN (380 Itálie), Filippo MEARELLI (380 Itálie), Pierandrea VINCI (380 Itálie), Boštjan ŠIMUNIČ (705 Slovinsko), Rado PIŠOT (705 Slovinsko), Marco NARICI (380 Itálie) a Gianini BIOLO (380 Itálie)

Vydání

FRONTIERS IN NUTRITION, Velká Británie, FRONTIERS MEDIA SA, 2021, 2296-861X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30306 Sport and fitness sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.590

Kód RIV

RIV/00216224:14510/21:00122857

Organizační jednotka

Fakulta sportovních studií

DOI

http://dx.doi.org/10.3389/fnut.2021.633987

UT WoS

000687378800001

Klíčová slova anglicky

bed rest; aging; muscle mass; muscle physiopathology; muscle function

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 5. 2022 09:52, Mgr. Pavlína Roučová, DiS.

Anotace

V originále

Background: Maintaining skeletal muscle mass and function in aging is crucial for preserving the quality of life and health. An experimental bed rest (BR) protocol is a suitable model to explore muscle decline on aging during inactivity. Objective: The purpose of this systematic review and meta-analysis was, therefore, to carry out an up-to-date evaluation of bed rest, with a specific focus on the magnitude of effects on muscle mass, strength, power, and functional capacity changes as well as the mechanisms, molecules, and pathways involved in muscle decay. Design: This was a systematic review and meta-analysis study. Data sources: We used PubMed, Medline; Web of Science, Google Scholar, and the Cochrane library, all of which were searched prior to April 23, 2020. A manual search was performed to cover bed rest experimental protocols using the following key terms, either singly or in combination: "Elderly Bed rest," "Older Bed rest," "Old Bed rest," "Aging Bed rest," "Aging Bed rest," "Bed-rest," and "Bedrest". Eligibility criteria for selecting studies: The inclusion criteria were divided into four sections: type of study, participants, interventions, and outcome measures. The primary outcome measures were: body mass index, fat mass, fat-free mass, leg lean mass, cross-sectional area, knee extension power, cytokine pattern, IGF signaling biomarkers, FOXO signaling biomarkers, mitochondrial modulation biomarkers, and muscle protein kinetics biomarkers. Results: A total of 25 studies were included in the qualitative synthesis, while 17 of them were included in the meta-analysis. In total, 118 healthy elderly volunteers underwent 5-, 7-, 10-, or 14-days of BR and provided a brief sketch on the possible mechanisms involved. In the very early phase of BR, important changes occurred in the skeletal muscle, with significant loss of performance associated with a lesser grade reduction of the total body and muscle mass. Meta-analysis of the effect of bed rest on total body mass was determined to be small but statistically significant (ES = -0.45, 95% CI: -0.72 to -0.19, P < 0.001). Moderate, statistically significant effects were observed for total lean body mass (ES = -0.67, 95% CI: -0.95 to -0.40, P < 0.001) after bed rest intervention. Overall, total lean body mass was decreased by 1.5 kg, while there was no relationship between bed rest duration and outcomes (Z = 0.423, p = 672). The meta-analyzed effect showed that bed rest produced large, statistically significant, effects (ES = -1.06, 95% CI: -1.37 to -0.75, P < 0.001) in terms of the knee extension power. Knee extension power was decreased by 14.65 N/s. In contrast, to other measures, meta-regression showed a significant relationship between bed rest duration and knee extension power (Z = 4.219, p < 0.001). Moderate, statistically significant, effects were observed after bed rest intervention for leg muscle mass in both old (ES = -0.68, 95% CI: -0.96 to -0.40, P < 0.001) and young (ES = -0.51, 95% CI: -0.80 to -0.22, P < 0.001) adults. However, the magnitude of change was higher in older (MD = -0.86 kg) compared to younger (MD = -0.24 kg) adults. Conclusion: Experimental BR is a suitable model to explore the detrimental effects of inactivity in young adults, old adults, and hospitalized people. Changes in muscle mass and function are the two most investigated variables, and they allow for a consistent trend in the BR-induced changes. Mechanisms underlying the greater loss of muscle mass and function in aging, following inactivity, need to be thoroughly investigated.

Citovat

DI GIROLAMO, Filippo Giorgio, Nicola FIOTTI, Zoran MILANOVIC, Roberta SITULIN, Filippo MEARELLI, Pierandrea VINCI, Boštjan ŠIMUNIČ, Rado PIŠOT, Marco NARICI a Gianini BIOLO. The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis. FRONTIERS IN NUTRITION. Velká Británie: FRONTIERS MEDIA SA, 2021, roč. 8, Aug 2021, s. nestránkováno, 13 s. ISSN 2296-861X. Dostupné z: https://dx.doi.org/10.3389/fnut.2021.633987.

@article{1803770,
   author = {Di Girolamo, Filippo Giorgio and Fiotti, Nicola and Milanovic, Zoran and Situlin, Roberta and Mearelli, Filippo and Vinci, Pierandrea and Šimunič, Boštjan and Pišot, Rado and Narici, Marco and Biolo, Gianini},
   article_location = {Velká Británie},
   article_number = {Aug 2021},
   doi = {http://dx.doi.org/10.3389/fnut.2021.633987},
   keywords = {bed rest; aging; muscle mass; muscle physiopathology; muscle function},
   language = {eng},
   issn = {2296-861X},
   journal = {FRONTIERS IN NUTRITION},
   title = {The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis},
   url = {https://www.frontiersin.org/articles/10.3389/fnut.2021.633987/full},
   volume = {8},
   year = {2021}
}

TY  - JOUR
ID  - 1803770
AU  - Di Girolamo, Filippo Giorgio - Fiotti, Nicola - Milanovic, Zoran - Situlin, Roberta - Mearelli, Filippo - Vinci, Pierandrea - Šimunič, Boštjan - Pišot, Rado - Narici, Marco - Biolo, Gianini
PY  - 2021
TI  - The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis
JF  - FRONTIERS IN NUTRITION
VL  - 8
IS  - Aug 2021
SP  - nestránkováno
EP  - nestránkováno
PB  - FRONTIERS MEDIA SA
SN  - 2296861X
KW  - bed rest
KW  - aging
KW  - muscle mass
KW  - muscle physiopathology
KW  - muscle function
UR  - https://www.frontiersin.org/articles/10.3389/fnut.2021.633987/full
N2  - Background: Maintaining skeletal muscle mass and function in aging is crucial for preserving the quality of life and health. An experimental bed rest (BR) protocol is a suitable model to explore muscle decline on aging during inactivity. Objective: The purpose of this systematic review and meta-analysis was, therefore, to carry out an up-to-date evaluation of bed rest, with a specific focus on the magnitude of effects on muscle mass, strength, power, and functional capacity changes as well as the mechanisms, molecules, and pathways involved in muscle decay. Design: This was a systematic review and meta-analysis study. Data sources: We used PubMed, Medline; Web of Science, Google Scholar, and the Cochrane library, all of which were searched prior to April 23, 2020. A manual search was performed to cover bed rest experimental protocols using the following key terms, either singly or in combination: "Elderly Bed rest," "Older Bed rest," "Old Bed rest," "Aging Bed rest," "Aging Bed rest," "Bed-rest," and "Bedrest". Eligibility criteria for selecting studies: The inclusion criteria were divided into four sections: type of study, participants, interventions, and outcome measures. The primary outcome measures were: body mass index, fat mass, fat-free mass, leg lean mass, cross-sectional area, knee extension power, cytokine pattern, IGF signaling biomarkers, FOXO signaling biomarkers, mitochondrial modulation biomarkers, and muscle protein kinetics biomarkers. Results: A total of 25 studies were included in the qualitative synthesis, while 17 of them were included in the meta-analysis. In total, 118 healthy elderly volunteers underwent 5-, 7-, 10-, or 14-days of BR and provided a brief sketch on the possible mechanisms involved. In the very early phase of BR, important changes occurred in the skeletal muscle, with significant loss of performance associated with a lesser grade reduction of the total body and muscle mass. Meta-analysis of the effect of bed rest on total body mass was determined to be small but statistically significant (ES = -0.45, 95% CI: -0.72 to -0.19, P < 0.001). Moderate, statistically significant effects were observed for total lean body mass (ES = -0.67, 95% CI: -0.95 to -0.40, P < 0.001) after bed rest intervention. Overall, total lean body mass was decreased by 1.5 kg, while there was no relationship between bed rest duration and outcomes (Z = 0.423, p = 672). The meta-analyzed effect showed that bed rest produced large, statistically significant, effects (ES = -1.06, 95% CI: -1.37 to -0.75, P < 0.001) in terms of the knee extension power. Knee extension power was decreased by 14.65 N/s. In contrast, to other measures, meta-regression showed a significant relationship between bed rest duration and knee extension power (Z = 4.219, p < 0.001). Moderate, statistically significant, effects were observed after bed rest intervention for leg muscle mass in both old (ES = -0.68, 95% CI: -0.96 to -0.40, P < 0.001) and young (ES = -0.51, 95% CI: -0.80 to -0.22, P < 0.001) adults. However, the magnitude of change was higher in older (MD = -0.86 kg) compared to younger (MD = -0.24 kg) adults. Conclusion: Experimental BR is a suitable model to explore the detrimental effects of inactivity in young adults, old adults, and hospitalized people. Changes in muscle mass and function are the two most investigated variables, and they allow for a consistent trend in the BR-induced changes. Mechanisms underlying the greater loss of muscle mass and function in aging, following inactivity, need to be thoroughly investigated.
ER  -

DI GIROLAMO, Filippo Giorgio, Nicola FIOTTI, Zoran MILANOVIC, Roberta SITULIN, Filippo MEARELLI, Pierandrea VINCI, Boštjan ŠIMUNIČ, Rado PIŠOT, Marco NARICI a Gianini BIOLO. The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis. \textit{FRONTIERS IN NUTRITION}. Velká Británie: FRONTIERS MEDIA SA, 2021, roč.~8, Aug 2021, s.~nestránkováno, 13 s. ISSN~2296-861X. Dostupné z: https://dx.doi.org/10.3389/fnut.2021.633987.

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