In vivo Molecular Signatures of Cervical Spinal Cord Pathology
in Degenerative Compression

J 2021

In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression

HORÁK, Tomáš, Magda HORÁKOVÁ, Alena SVÁTKOVÁ, Zdeněk KADAŇKA, Petr KUDLIČKA et. al.

Základní údaje

Originální název

In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression

Autoři

HORÁK, Tomáš (203 Česká republika, domácí), Magda HORÁKOVÁ (203 Česká republika, domácí), Alena SVÁTKOVÁ (703 Slovensko), Zdeněk KADAŇKA (203 Česká republika, domácí), Petr KUDLIČKA (203 Česká republika, domácí), Jan VALOSEK (203 Česká republika), Tomáš ROHAN (203 Česká republika), Miloš KEŘKOVSKÝ (203 Česká republika), Eva VLČKOVÁ (203 Česká republika, domácí), Zdeněk KADAŇKA (203 Česká republika), Dinesh K. DEELCHAND, Pierre-Gilles HENRY, Josef BEDNAŘÍK (203 Česká republika, domácí) a Petr BEDNAŘÍK (203 Česká republika, garant, domácí)

Vydání

Journal of Neurotrauma, New Rochelle, Mary Ann Liebert, 2021, 0897-7151

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.869

Kód RIV

RIV/00216224:14110/21:00120166

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1089/neu.2021.0151

UT WoS

000745030000006

Klíčová slova anglicky

cervical spinal cord; compression; degenerative magnetic resonance; myelopathy; spectroscopy

Štítky

14110127, 14110221, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 10. 2024 13:35, Ing. Jana Kuchtová

Anotace

V originále

Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC compression and 47 healthy controls (HCs). The MRS voxel was centered at the C2 level. Compression-affected participants were clinically categorized as NMDC and DCM, radiologically as mild (MC) or severe (SC) compression. CSC volumes and neurochemical concentrations were compared between cohorts (HC vs. NMDC vs. DCM and HC vs. MC vs. SC) with general linear models adjusted for age and height (pFWE < 0.05) and correlated to stenosis severity, electrophysiology, and myelopathy symptoms (p < 0.05). Whereas the ratio of total creatine (tCr) to total N-acetylaspartate (tNAA) increased in NMDC (+11%) and in DCM (+26%) and SC (+21%), myo-inositol/tNAA, glutamate + glutamine/tNAA, and volumes changed only in DCM (+20%, +73%, and −14%) and SC (+12%, +46%, and −8%, respectively) relative to HCs. Both tCr/tNAA and myo-inositol/tNAA correlated with compression severity and volume (−0.376 < r < −0.259). Myo-inositol/tNAA correlated with myelopathy symptoms (r = −0.670), whereas CSC volume did not. Short-echo 1H-MRS provided neurochemical signatures of CSC impairment that reflected compression severity and clinical significance. Whereas volumetry only reflected clinically manifest myelopathy (DCM), MRS detected neurochemical changes already before the onset of myelopathy symptoms.

Návaznosti

NV18-04-00159, projekt VaV

Název: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministerstvo zdravotnictví ČR, Využití pokročilých magneticko-rezonančních technik k objasnění patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

90042, velká výzkumná infrastruktura

Název: CESNET II

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

HORÁK, Tomáš, Magda HORÁKOVÁ, Alena SVÁTKOVÁ, Zdeněk KADAŇKA, Petr KUDLIČKA, Jan VALOSEK, Tomáš ROHAN, Miloš KEŘKOVSKÝ, Eva VLČKOVÁ, Zdeněk KADAŇKA, Dinesh K. DEELCHAND, Pierre-Gilles HENRY, Josef BEDNAŘÍK a Petr BEDNAŘÍK. In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression. Journal of Neurotrauma. New Rochelle: Mary Ann Liebert, 2021, roč. 38, č. 21, s. 2999-3010. ISSN 0897-7151. Dostupné z: https://dx.doi.org/10.1089/neu.2021.0151.

@article{1804614,
   author = {Horák, Tomáš and Horáková, Magda and Svátková, Alena and Kadaňka, Zdeněk and Kudlička, Petr and Valosek, Jan and Rohan, Tomáš and Keřkovský, Miloš and Vlčková, Eva and Kadaňka, Zdeněk and Deelchand, Dinesh K. and Henry, PierreandGilles and Bednařík, Josef and Bednařík, Petr},
   article_location = {New Rochelle},
   article_number = {21},
   doi = {http://dx.doi.org/10.1089/neu.2021.0151},
   keywords = {cervical spinal cord; compression; degenerative magnetic resonance; myelopathy; spectroscopy},
   language = {eng},
   issn = {0897-7151},
   journal = {Journal of Neurotrauma},
   title = {In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression},
   url = {https://www.liebertpub.com/doi/10.1089/neu.2021.0151},
   volume = {38},
   year = {2021}
}

TY  - JOUR
ID  - 1804614
AU  - Horák, Tomáš - Horáková, Magda - Svátková, Alena - Kadaňka, Zdeněk - Kudlička, Petr - Valosek, Jan - Rohan, Tomáš - Keřkovský, Miloš - Vlčková, Eva - Kadaňka, Zdeněk - Deelchand, Dinesh K. - Henry, Pierre-Gilles - Bednařík, Josef - Bednařík, Petr
PY  - 2021
TI  - In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression
JF  - Journal of Neurotrauma
VL  - 38
IS  - 21
SP  - 2999-3010
EP  - 2999-3010
PB  - Mary Ann Liebert
SN  - 08977151
KW  - cervical spinal cord
KW  - compression
KW  - degenerative magnetic resonance
KW  - myelopathy
KW  - spectroscopy
UR  - https://www.liebertpub.com/doi/10.1089/neu.2021.0151
N2  - Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC compression and 47 healthy controls (HCs). The MRS voxel was centered at the C2 level. Compression-affected participants were clinically categorized as NMDC and DCM, radiologically as mild (MC) or severe (SC) compression. CSC volumes and neurochemical concentrations were compared between cohorts (HC vs. NMDC vs. DCM and HC vs. MC vs. SC) with general linear models adjusted for age and height (pFWE < 0.05) and correlated to stenosis severity, electrophysiology, and myelopathy symptoms (p < 0.05). Whereas the ratio of total creatine (tCr) to total N-acetylaspartate (tNAA) increased in NMDC (+11%) and in DCM (+26%) and SC (+21%), myo-inositol/tNAA, glutamate + glutamine/tNAA, and volumes changed only in DCM (+20%, +73%, and −14%) and SC (+12%, +46%, and −8%, respectively) relative to HCs. Both tCr/tNAA and myo-inositol/tNAA correlated with compression severity and volume (−0.376 < r < −0.259). Myo-inositol/tNAA correlated with myelopathy symptoms (r = −0.670), whereas CSC volume did not. Short-echo 1H-MRS provided neurochemical signatures of CSC impairment that reflected compression severity and clinical significance. Whereas volumetry only reflected clinically manifest myelopathy (DCM), MRS detected neurochemical changes already before the onset of myelopathy symptoms.
ER  -

HORÁK, Tomáš, Magda HORÁKOVÁ, Alena SVÁTKOVÁ, Zdeněk KADAŇKA, Petr KUDLIČKA, Jan VALOSEK, Tomáš ROHAN, Miloš KEŘKOVSKÝ, Eva VLČKOVÁ, Zdeněk KADAŇKA, Dinesh K. DEELCHAND, Pierre-Gilles HENRY, Josef BEDNAŘÍK a Petr BEDNAŘÍK. In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression. \textit{Journal of Neurotrauma}. New Rochelle: Mary Ann Liebert, 2021, roč.~38, č.~21, s.~2999-3010. ISSN~0897-7151. Dostupné z: https://dx.doi.org/10.1089/neu.2021.0151.

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