Osmolarita slz, její měření a korelace s dalšími testy pro vyšetření suchého oka

VESELÝ, Petr, Pavel BENEŠ, Petra ZÁDĚROVÁ a Jana SOKOLOVÁ ŠIDLOVÁ. Osmolarita slz, její měření a korelace s dalšími testy pro vyšetření suchého oka. In Oftalmologický tematický kurz. 2021.

Základní údaje

• Originální název: Osmolarita slz, její měření a korelace s dalšími testy pro vyšetření suchého oka
• Název česky: Osmolarita slz, její měření a korelace s dalšími testy pro vyšetření suchého oka
• Název anglicky: Tear osmolarity, its measurement and correlation with other tests for dry eye examination
• Autoři: VESELÝ, Petr (203 Česká republika, garant, domácí), Pavel BENEŠ (203 Česká republika), Petra ZÁDĚROVÁ (203 Česká republika) a Jana SOKOLOVÁ ŠIDLOVÁ (203 Česká republika).
• Vydání: Oftalmologický tematický kurz, 2021.

Další údaje

• Originální jazyk: čeština
• Typ výsledku: Vyžádané přednášky
• Obor: 30207 Ophthalmology
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Kód RIV: RIV/00216224:14110/21:00122910
• Organizační jednotka: Lékařská fakulta
• Klíčová slova česky: Tearlab;osmolarita;dotazník DEQ-5;syndrom suchého oka;Sjogrenův syndrom;break time test
• Klíčová slova anglicky: Tearlab;osmolarity;DEQ-5 questionnaire;dry eye syndrome;Sjogren’s syndrome;break time test

Anotace

Abstract Aim: To determine the values of osmolarity of tears of the right and left eye in individual probands, to evaluate their symptoms using the DEQ-5 questionnaire and to compare the results with other studies. Furthermore, to find out how invasive and non-invasive methods of tear film quality evaluation correlate together. Methods: In our study, we had data from 20 probands, whose average age was 23.5 years (SD 1.55 years). All subjects underwent a standard optometric examination, including the determination of the current subjective correction of the refractive error. Subsequently, we presented the DEQ-5 questionnaire to the probands. After completing the questionnaires, each proband underwent tear osmolarity using a TearLab® instrument (TearLab Corporation, USA). Further examination was performed on a Keratograph 5M® (Oculus, Germany). Results: The average value of tear osmolarity in the right and left eye of all probands was 300.35 (SD 16.52) and 293.70 (SD 12.92) mOsmol/l, respectively. The difference in the osmolarity of both eyes in one proband greater than 8 mOsmol/l inclusive was identified in a total of 11 probands out of 20 (i.e. 55 %). The mean value of the non-invasive break time test (nBUT) on the right and left eyes of all probands was 14.05 s (SD 5.78 s) and 15.59 s (SD 6.13 s), respectively. From the DEQ-5 questionnaire, we recorded a positive capture (score equal to greater than 6 points) in a total of 8 probands out of 20 (i.e. 40 %). Conclusion: The results of our study show that there is no correlation between non-invasive break time test (nBUT) and tear osmolarity (difTL8, R = 0.23 at p = 0.32). To evaluate the symptoms of dry eye disease, a special questionnaire with 5 questions (Dry Eye Questionnaire, DEQ-5) proved to be very accurate and effective, which helped us to accurately divide the baseline group into a symptomatic group and a group without symptoms (p <0.001). Subsequently, we demonstrated statistically significant sensitivity and specificity in both tests (nBUT, difTL8).

Anotace anglicky

Abstract Aim: To determine the values of osmolarity of tears of the right and left eye in individual probands, to evaluate their symptoms using the DEQ-5 questionnaire and to compare the results with other studies. Furthermore, to find out how invasive and non-invasive methods of tear film quality evaluation correlate together. Methods: In our study, we had data from 20 probands, whose average age was 23.5 years (SD 1.55 years). All subjects underwent a standard optometric examination, including the determination of the current subjective correction of the refractive error. Subsequently, we presented the DEQ-5 questionnaire to the probands. After completing the questionnaires, each proband underwent tear osmolarity using a TearLab® instrument (TearLab Corporation, USA). Further examination was performed on a Keratograph 5M® (Oculus, Germany). Results: The average value of tear osmolarity in the right and left eye of all probands was 300.35 (SD 16.52) and 293.70 (SD 12.92) mOsmol/l, respectively. The difference in the osmolarity of both eyes in one proband greater than 8 mOsmol/l inclusive was identified in a total of 11 probands out of 20 (i.e. 55 %). The mean value of the non-invasive break time test (nBUT) on the right and left eyes of all probands was 14.05 s (SD 5.78 s) and 15.59 s (SD 6.13 s), respectively. From the DEQ-5 questionnaire, we recorded a positive capture (score equal to greater than 6 points) in a total of 8 probands out of 20 (i.e. 40 %). Conclusion: The results of our study show that there is no correlation between non-invasive break time test (nBUT) and tear osmolarity (difTL8, R = 0.23 at p = 0.32). To evaluate the symptoms of dry eye disease, a special questionnaire with 5 questions (Dry Eye Questionnaire, DEQ-5) proved to be very accurate and effective, which helped us to accurately divide the baseline group into a symptomatic group and a group without symptoms (p <0.001). Subsequently, we demonstrated statistically significant sensitivity and specificity in both tests (nBUT, difTL8).

Návaznosti

• MUNI/11/0993/2020, interní kód MU: Název: Stanovení fyziologických hodnot osmolarity pomocí zařízení TearLab a korelace těchto hodnot s dalšími neinvazivními testy slzného filmu (Akronym: TEFILOM)

Investor: Masarykova univerzita, Stanovení fyziologických hodnot osmolarity pomocí zařízení TearLab a korelace těchto hodnot s dalšími neinvazivními testy slzného filmu