Articulatory network reorganization in Parkinson ? s disease as
assessed by multimodal MRI and acoustic measures

J 2021

Articulatory network reorganization in Parkinson ? s disease as assessed by multimodal MRI and acoustic measures

KLOBUŠIAKOVÁ, Patrícia; J. MEKYSKA; Luboš BRABENEC; Z. GALAZ; V. ZVONCAK et. al.

Základní údaje

Originální název

Articulatory network reorganization in Parkinson ? s disease as assessed by multimodal MRI and acoustic measures

Autoři

KLOBUŠIAKOVÁ, Patrícia (703 Slovensko, domácí); J. MEKYSKA (203 Česká republika); Luboš BRABENEC (203 Česká republika, domácí); Z. GALAZ; V. ZVONCAK; J. MUCHA; S.Z. RAPCSAK a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2021, 1353-8020

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.402

Kód RIV

RIV/00216224:14740/21:00120169

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.parkreldis.2021.02.012

UT WoS

000632026700020

EID Scopus

2-s2.0-85101359663

Klíčová slova anglicky

Acoustic analysis; Hypokinetic dysarthria; fMRI; Parkinson?s disease; Voxel-based morphometry; Resting-state functional connectivity

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 10. 2024 13:00, Ing. Jana Kuchtová

Anotace

V originále

Introduction: Hypokinetic dysarthria (HD) is common in Parkinson?s disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.

Návaznosti

EF16_013/0001775, projekt VaV

Název: Modernizace a podpora výzkumných aktivit národní infrastruktury pro biologické a medicínské zobrazování Czech-BioImaging

NU20-04-00294, projekt VaV

Název: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Investor: Ministerstvo zdravotnictví ČR, Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

734718, interní kód MU

Název: Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology (Akronym: CoBeN)

Investor: Evropská unie, Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Přiložené soubory

PIIS1353802021000535.pdf

Citovat

KLOBUŠIAKOVÁ, Patrícia; J. MEKYSKA; Luboš BRABENEC; Z. GALAZ; V. ZVONCAK; J. MUCHA; S.Z. RAPCSAK a Irena REKTOROVÁ. Articulatory network reorganization in Parkinson ? s disease as assessed by multimodal MRI and acoustic measures. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2021, roč. 84, MAR, s. 122-128. ISSN 1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2021.02.012.

@article{1805259,
   author = {Klobušiaková, Patrícia and Mekyska, J. and Brabenec, Luboš and Galaz, Z. and Zvoncak, V. and Mucha, J. and Rapcsak, S.Z. and Rektorová, Irena},
   article_location = {OXFORD},
   article_number = {MAR},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2021.02.012},
   keywords = {Acoustic analysis; Hypokinetic dysarthria; fMRI; Parkinson?s disease; Voxel-based morphometry; Resting-state functional connectivity},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Articulatory network reorganization in Parkinson ? s disease as assessed by multimodal MRI and acoustic measures},
   url = {https://www.sciencedirect.com/science/article/pii/S1353802021000535?via%3Dihub},
   volume = {84},
   year = {2021}
}

TY  - JOUR
ID  - 1805259
AU  - Klobušiaková, Patrícia - Mekyska, J. - Brabenec, Luboš - Galaz, Z. - Zvoncak, V. - Mucha, J. - Rapcsak, S.Z. - Rektorová, Irena
PY  - 2021
TI  - Articulatory network reorganization in Parkinson ? s disease as assessed by multimodal MRI and acoustic measures
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 84
IS  - MAR
SP  - 122-128
EP  - 122-128
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - Acoustic analysis
KW  - Hypokinetic dysarthria
KW  - fMRI
KW  - Parkinson?s disease
KW  - Voxel-based morphometry
KW  - Resting-state functional connectivity
UR  - https://www.sciencedirect.com/science/article/pii/S1353802021000535?via%3Dihub
N2  - Introduction: Hypokinetic dysarthria (HD) is common in Parkinson?s disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.
ER  -

KLOBUŠIAKOVÁ, Patrícia; J. MEKYSKA; Luboš BRABENEC; Z. GALAZ; V. ZVONCAK; J. MUCHA; S.Z. RAPCSAK a Irena REKTOROVÁ. Articulatory network reorganization in Parkinson ? s disease as assessed by multimodal MRI and acoustic measures. \textit{PARKINSONISM \&{}amp; RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2021, roč.~84, MAR, s.~122-128. ISSN~1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2021.02.012.

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