Penis as a primary site of an extraskeletal Ewing sarcoma A
case report

J 2021

Penis as a primary site of an extraskeletal Ewing sarcoma A case report

ADÁMKOVÁ KRÁKOROVÁ, Dagmar, Jana HALÁMKOVÁ, Štěpán TUČEK, Ondřej BÍLEK, Jan KRISTEK et. al.

Základní údaje

Originální název

Penis as a primary site of an extraskeletal Ewing sarcoma A case report

Autoři

ADÁMKOVÁ KRÁKOROVÁ, Dagmar (203 Česká republika), Jana HALÁMKOVÁ (203 Česká republika, garant, domácí), Štěpán TUČEK (203 Česká republika, domácí), Ondřej BÍLEK (203 Česká republika, domácí), Jan KRISTEK (203 Česká republika), Tomáš KAZDA (203 Česká republika, domácí), Iva ZAMBO (203 Česká republika, domácí), Regina DEMLOVÁ (203 Česká republika, domácí) a Igor KISS (203 Česká republika, domácí)

Vydání

Medicine, Philadelphia, Lippincott Williams & Wilkins, 2021, 0025-7974

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.817

Kód RIV

RIV/00216224:14110/21:00120171

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/MD.0000000000025074

UT WoS

000659055900064

Klíčová slova česky

extraskeletal Ewing sarcoma; multidisciplinary treatment; penis

Klíčová slova anglicky

extraskeletal Ewing sarcoma; multidisciplinary treatment; penis

Štítky

14110112, 14110516, 14110522, 14110811, 14110812, MOÚ, MU, RIV, rivok, user

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 2. 2022 08:47, Mgr. Tereza Miškechová

Anotace

V originále

Rationale: The Ewing sarcoma family of malignant tumors is a group of tumors characterized by morphologically similar round-cell neoplasms and by the presence of a common chromosomal translocation; Ewing sarcoma family of tumors typically occur in children and young adults between 4 to 15 years of age. The primary tumor usually originates in the bone, extraskeletal localization is rare. Patient concern: We present a case report concerning a 32-year-old male patient with a primary involvement of the penis. Diagnosis: The histopathology from the first penile biopsy showed a small-cell neuroendocrine carcinoma; however, that result was based on a sample obtained at a different facility than the Sarcoma Center, where the investigating pathologist did not have the adequate expertise. The patient then underwent a radical penectomy and a second reading of the histology was demanded after a radical penile amputation when Ewing sarcoma with R1 resection was confirmed. Interventions: The patient was referred to the national Sarcoma Center, where - using a multidisciplinary approach - the treatment was started with curative intent. However, it was preceded by a non-standard initiation of the therapy due to the poor primary diagnosis. Outcomes: The non-standard therapy at the onset of the disease caused a poor prognosis of an otherwise curable diagnosis. Despite all that, the patient survived for a relatively long time. Lessons: The treatment of sarcomas with atypical localizations should be conducted by an experienced multidisciplinary team in a center with experience in sarcoma treatment.

Návaznosti

NV18-07-00073, projekt VaV

Název: c-Myb a jeho transkripční program ve fyziologických a patologických osteogenních procesech

Investor: Ministerstvo zdravotnictví ČR, c-Myb a jeho transkripční program ve fyziologických a patologických osteogenních procesech

90128, velká výzkumná infrastruktura

Název: CZECRIN III

Citovat

ADÁMKOVÁ KRÁKOROVÁ, Dagmar, Jana HALÁMKOVÁ, Štěpán TUČEK, Ondřej BÍLEK, Jan KRISTEK, Tomáš KAZDA, Iva ZAMBO, Regina DEMLOVÁ a Igor KISS. Penis as a primary site of an extraskeletal Ewing sarcoma A case report. Medicine. Philadelphia: Lippincott Williams & Wilkins, 2021, roč. 100, č. 11, s. 1-5. ISSN 0025-7974. Dostupné z: https://dx.doi.org/10.1097/MD.0000000000025074.

@article{1807088,
   author = {Adámková Krákorová, Dagmar and Halámková, Jana and Tuček, Štěpán and Bílek, Ondřej and Kristek, Jan and Kazda, Tomáš and Zambo, Iva and Demlová, Regina and Kiss, Igor},
   article_location = {Philadelphia},
   article_number = {11},
   doi = {http://dx.doi.org/10.1097/MD.0000000000025074},
   keywords = {extraskeletal Ewing sarcoma; multidisciplinary treatment; penis},
   language = {eng},
   issn = {0025-7974},
   journal = {Medicine},
   title = {Penis as a primary site of an extraskeletal Ewing sarcoma A case report},
   url = {https://journals.lww.com/md-journal/Fulltext/2021/03190/Penis_as_a_primary_site_of_an_extraskeletal_Ewing.64.aspx},
   volume = {100},
   year = {2021}
}

TY  - JOUR
ID  - 1807088
AU  - Adámková Krákorová, Dagmar - Halámková, Jana - Tuček, Štěpán - Bílek, Ondřej - Kristek, Jan - Kazda, Tomáš - Zambo, Iva - Demlová, Regina - Kiss, Igor
PY  - 2021
TI  - Penis as a primary site of an extraskeletal Ewing sarcoma A case report
JF  - Medicine
VL  - 100
IS  - 11
SP  - 1-5
EP  - 1-5
PB  - Lippincott Williams & Wilkins
SN  - 00257974
KW  - extraskeletal Ewing sarcoma
KW  - multidisciplinary treatment
KW  - penis
UR  - https://journals.lww.com/md-journal/Fulltext/2021/03190/Penis_as_a_primary_site_of_an_extraskeletal_Ewing.64.aspx
N2  - Rationale: The Ewing sarcoma family of malignant tumors is a group of tumors characterized by morphologically similar round-cell neoplasms and by the presence of a common chromosomal translocation; Ewing sarcoma family of tumors typically occur in children and young adults between 4 to 15 years of age. The primary tumor usually originates in the bone, extraskeletal localization is rare. Patient concern: We present a case report concerning a 32-year-old male patient with a primary involvement of the penis. Diagnosis: The histopathology from the first penile biopsy showed a small-cell neuroendocrine carcinoma; however, that result was based on a sample obtained at a different facility than the Sarcoma Center, where the investigating pathologist did not have the adequate expertise. The patient then underwent a radical penectomy and a second reading of the histology was demanded after a radical penile amputation when Ewing sarcoma with R1 resection was confirmed. Interventions: The patient was referred to the national Sarcoma Center, where - using a multidisciplinary approach - the treatment was started with curative intent. However, it was preceded by a non-standard initiation of the therapy due to the poor primary diagnosis. Outcomes: The non-standard therapy at the onset of the disease caused a poor prognosis of an otherwise curable diagnosis. Despite all that, the patient survived for a relatively long time. Lessons: The treatment of sarcomas with atypical localizations should be conducted by an experienced multidisciplinary team in a center with experience in sarcoma treatment.
ER  -

ADÁMKOVÁ KRÁKOROVÁ, Dagmar, Jana HALÁMKOVÁ, Štěpán TUČEK, Ondřej BÍLEK, Jan KRISTEK, Tomáš KAZDA, Iva ZAMBO, Regina DEMLOVÁ a Igor KISS. Penis as a primary site of an extraskeletal Ewing sarcoma A case report. \textit{Medicine}. Philadelphia: Lippincott Williams \&{} Wilkins, 2021, roč.~100, č.~11, s.~1-5. ISSN~0025-7974. Dostupné z: https://dx.doi.org/10.1097/MD.0000000000025074.

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