Penis as a primary site of an extraskeletal Ewing sarcoma A
case report

J 2021

Penis as a primary site of an extraskeletal Ewing sarcoma A case report

ADÁMKOVÁ KRÁKOROVÁ, Dagmar; Jana HALÁMKOVÁ; Štěpán TUČEK; Ondřej BÍLEK; Jan KRISTEK et. al.

Základní údaje

Originální název

Penis as a primary site of an extraskeletal Ewing sarcoma A case report

Autoři

ADÁMKOVÁ KRÁKOROVÁ, Dagmar (203 Česká republika); Jana HALÁMKOVÁ (203 Česká republika, garant, domácí); Štěpán TUČEK (203 Česká republika, domácí); Ondřej BÍLEK (203 Česká republika, domácí); Jan KRISTEK (203 Česká republika); Tomáš KAZDA (203 Česká republika, domácí); Iva ZAMBO (203 Česká republika, domácí); Regina DEMLOVÁ (203 Česká republika, domácí) a Igor KISS (203 Česká republika, domácí)

Vydání

Medicine, Philadelphia, Lippincott Williams & Wilkins, 2021, 0025-7974

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.817

Kód RIV

RIV/00216224:14110/21:00120171

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/MD.0000000000025074

UT WoS

000659055900064

EID Scopus

2-s2.0-85103073618

Klíčová slova česky

extraskeletal Ewing sarcoma; multidisciplinary treatment; penis

Klíčová slova anglicky

extraskeletal Ewing sarcoma; multidisciplinary treatment; penis

Štítky

14110112, 14110516, 14110522, 14110811, 14110812, MOÚ, MU, RIV, rivok, user

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 2. 2022 08:47, Mgr. Tereza Miškechová

Anotace

V originále

Rationale: The Ewing sarcoma family of malignant tumors is a group of tumors characterized by morphologically similar round-cell neoplasms and by the presence of a common chromosomal translocation; Ewing sarcoma family of tumors typically occur in children and young adults between 4 to 15 years of age. The primary tumor usually originates in the bone, extraskeletal localization is rare. Patient concern: We present a case report concerning a 32-year-old male patient with a primary involvement of the penis. Diagnosis: The histopathology from the first penile biopsy showed a small-cell neuroendocrine carcinoma; however, that result was based on a sample obtained at a different facility than the Sarcoma Center, where the investigating pathologist did not have the adequate expertise. The patient then underwent a radical penectomy and a second reading of the histology was demanded after a radical penile amputation when Ewing sarcoma with R1 resection was confirmed. Interventions: The patient was referred to the national Sarcoma Center, where - using a multidisciplinary approach - the treatment was started with curative intent. However, it was preceded by a non-standard initiation of the therapy due to the poor primary diagnosis. Outcomes: The non-standard therapy at the onset of the disease caused a poor prognosis of an otherwise curable diagnosis. Despite all that, the patient survived for a relatively long time. Lessons: The treatment of sarcomas with atypical localizations should be conducted by an experienced multidisciplinary team in a center with experience in sarcoma treatment.

Návaznosti

NV18-07-00073, projekt VaV

Název: c-Myb a jeho transkripční program ve fyziologických a patologických osteogenních procesech

Investor: Ministerstvo zdravotnictví ČR, c-Myb a jeho transkripční program ve fyziologických a patologických osteogenních procesech

90128, velká výzkumná infrastruktura

Název: CZECRIN III

Citovat

ADÁMKOVÁ KRÁKOROVÁ, Dagmar; Jana HALÁMKOVÁ; Štěpán TUČEK; Ondřej BÍLEK; Jan KRISTEK; Tomáš KAZDA; Iva ZAMBO; Regina DEMLOVÁ a Igor KISS. Penis as a primary site of an extraskeletal Ewing sarcoma A case report. Medicine. Philadelphia: Lippincott Williams & Wilkins, 2021, roč. 100, č. 11, s. 1-5. ISSN 0025-7974. Dostupné z: https://dx.doi.org/10.1097/MD.0000000000025074.

@article{1807088,
   author = {Adámková Krákorová, Dagmar and Halámková, Jana and Tuček, Štěpán and Bílek, Ondřej and Kristek, Jan and Kazda, Tomáš and Zambo, Iva and Demlová, Regina and Kiss, Igor},
   article_location = {Philadelphia},
   article_number = {11},
   doi = {http://dx.doi.org/10.1097/MD.0000000000025074},
   keywords = {extraskeletal Ewing sarcoma; multidisciplinary treatment; penis},
   language = {eng},
   issn = {0025-7974},
   journal = {Medicine},
   title = {Penis as a primary site of an extraskeletal Ewing sarcoma A case report},
   url = {https://journals.lww.com/md-journal/Fulltext/2021/03190/Penis_as_a_primary_site_of_an_extraskeletal_Ewing.64.aspx},
   volume = {100},
   year = {2021}
}

TY  - JOUR
ID  - 1807088
AU  - Adámková Krákorová, Dagmar - Halámková, Jana - Tuček, Štěpán - Bílek, Ondřej - Kristek, Jan - Kazda, Tomáš - Zambo, Iva - Demlová, Regina - Kiss, Igor
PY  - 2021
TI  - Penis as a primary site of an extraskeletal Ewing sarcoma A case report
JF  - Medicine
VL  - 100
IS  - 11
SP  - 1-5
EP  - 1-5
PB  - Lippincott Williams & Wilkins
SN  - 00257974
KW  - extraskeletal Ewing sarcoma
KW  - multidisciplinary treatment
KW  - penis
UR  - https://journals.lww.com/md-journal/Fulltext/2021/03190/Penis_as_a_primary_site_of_an_extraskeletal_Ewing.64.aspx
N2  - Rationale: The Ewing sarcoma family of malignant tumors is a group of tumors characterized by morphologically similar round-cell neoplasms and by the presence of a common chromosomal translocation; Ewing sarcoma family of tumors typically occur in children and young adults between 4 to 15 years of age. The primary tumor usually originates in the bone, extraskeletal localization is rare. Patient concern: We present a case report concerning a 32-year-old male patient with a primary involvement of the penis. Diagnosis: The histopathology from the first penile biopsy showed a small-cell neuroendocrine carcinoma; however, that result was based on a sample obtained at a different facility than the Sarcoma Center, where the investigating pathologist did not have the adequate expertise. The patient then underwent a radical penectomy and a second reading of the histology was demanded after a radical penile amputation when Ewing sarcoma with R1 resection was confirmed. Interventions: The patient was referred to the national Sarcoma Center, where - using a multidisciplinary approach - the treatment was started with curative intent. However, it was preceded by a non-standard initiation of the therapy due to the poor primary diagnosis. Outcomes: The non-standard therapy at the onset of the disease caused a poor prognosis of an otherwise curable diagnosis. Despite all that, the patient survived for a relatively long time. Lessons: The treatment of sarcomas with atypical localizations should be conducted by an experienced multidisciplinary team in a center with experience in sarcoma treatment.
ER  -

ADÁMKOVÁ KRÁKOROVÁ, Dagmar; Jana HALÁMKOVÁ; Štěpán TUČEK; Ondřej BÍLEK; Jan KRISTEK; Tomáš KAZDA; Iva ZAMBO; Regina DEMLOVÁ a Igor KISS. Penis as a primary site of an extraskeletal Ewing sarcoma A case report. \textit{Medicine}. Philadelphia: Lippincott Williams \&{} Wilkins, 2021, roč.~100, č.~11, s.~1-5. ISSN~0025-7974. Dostupné z: https://dx.doi.org/10.1097/MD.0000000000025074.

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