FRELICH, M., J. DIVAK, V. VODICKA, M. MASAROVA, O. JOR and R. GAL. Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage. MEDICAL SCIENCE MONITOR. MELVILLE: INT SCIENTIFIC INFORMATION, INC, vol. 24, p. 8430-8438. ISSN 1643-3750. doi:10.12659/MSM.911231. 2018.
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Basic information
Original name Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage
Name in Czech Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage
Authors FRELICH, M., J. DIVAK, V. VODICKA, M. MASAROVA, O. JOR and R. GAL.
Edition MEDICAL SCIENCE MONITOR, MELVILLE, INT SCIENTIFIC INFORMATION, INC, 2018, 1643-3750.
Other information
Original language English
Type of outcome Article in a journal
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.980
Doi http://dx.doi.org/10.12659/MSM.911231
UT WoS 000451039400003
Keywords (in Czech) Adenoidectomy; Dexamethasone; Postoperative Complications; Postoperative Nausea and Vomiting
Keywords in English Adenoidectomy; Dexamethasone; Postoperative Complications; Postoperative Nausea and Vomiting
Tags Excelence Science, FN Brno, FN OSTRAVA, RIV, user
Tags International impact
Changed by Changed by: Bc. Hana Vladíková, BBA, učo 244692. Changed: 7/12/2021 14:29.
Abstract
Background: Postoperative nausea and vomiting (PONV) is a common complication of pediatric anesthesia, but the overall incidence of PONV in patients undergoing adenoidectomy is unknown. The aim of this controlled study was to compare the effect of dexamethasone administration with placebo to reduce PONV in children undergoing endoscopic adenoidectomy under general anesthesia. Material/Methods: A randomized placebo-controlled study included 118 pediatric patients who underwent elective endoscopic adenoidectomy under general anesthesia. A dexamethasone-treated (0.15 mg/kg) group (Group D) (n=56) and a placebo group (Group C) (n=62) were randomly assigned. The incidence of nausea and vomiting was recorded on the day of surgery. Postoperative nausea was assessed according to illustrated Baxter Animated Retching Faces (BARF) scale. The Face, Legs, Activity, Cry, and Consolability (FLACC) scale (scores between 0-10) was used to assess pain. Follow-up was performed on the 14th postoperative day by a telephone call. Results: Overall prevalence of postoperative nausea was 25% (30/118) and postoperative vomiting was 14% (17/118). In the first 24 hours following surgery, in Group D, the incidence of nausea and vomiting was 13% and 7%, respectively; in Group C, without pharmacological prophylaxis, the incidence of postoperative nausea and vomiting was 37%, and 21%, respectively. Conclusions: A prospective controlled study in children undergoing endoscopic adenoidectomy under general anesthesia showed that dexamethasone (0.15 mg/kg) significantly reduced the incidence of PONV without increasing the risk of postoperative hemorrhage. Dexamethasone is a safe method for the prevention of PONV that may be recommended in pediatric anesthesiology.
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