Dexamethasone Reduces the Incidence of Postoperative Nausea and
Vomiting in Children Undergoing Endoscopic Adenoidectomy under
General Anesthesia Without Increasing the Risk of Postoperative
Hemorrhage

J 2018

Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage

FRELICH, M., J. DIVAK, V. VODICKA, M. MASAROVA, O. JOR et. al.

Basic information

Original name

Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage

Name in Czech

Authors

FRELICH, M., J. DIVAK, V. VODICKA, M. MASAROVA, O. JOR and R. GAL

Edition

MEDICAL SCIENCE MONITOR, MELVILLE, INT SCIENTIFIC INFORMATION, INC, 2018, 1643-3750

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.980

DOI

http://dx.doi.org/10.12659/MSM.911231

UT WoS

000451039400003

Keywords (in Czech)

Adenoidectomy; Dexamethasone; Postoperative Complications; Postoperative Nausea and Vomiting

Keywords in English

Adenoidectomy; Dexamethasone; Postoperative Complications; Postoperative Nausea and Vomiting

Abstract

V originále

Background: Postoperative nausea and vomiting (PONV) is a common complication of pediatric anesthesia, but the overall incidence of PONV in patients undergoing adenoidectomy is unknown. The aim of this controlled study was to compare the effect of dexamethasone administration with placebo to reduce PONV in children undergoing endoscopic adenoidectomy under general anesthesia. Material/Methods: A randomized placebo-controlled study included 118 pediatric patients who underwent elective endoscopic adenoidectomy under general anesthesia. A dexamethasone-treated (0.15 mg/kg) group (Group D) (n=56) and a placebo group (Group C) (n=62) were randomly assigned. The incidence of nausea and vomiting was recorded on the day of surgery. Postoperative nausea was assessed according to illustrated Baxter Animated Retching Faces (BARF) scale. The Face, Legs, Activity, Cry, and Consolability (FLACC) scale (scores between 0-10) was used to assess pain. Follow-up was performed on the 14th postoperative day by a telephone call. Results: Overall prevalence of postoperative nausea was 25% (30/118) and postoperative vomiting was 14% (17/118). In the first 24 hours following surgery, in Group D, the incidence of nausea and vomiting was 13% and 7%, respectively; in Group C, without pharmacological prophylaxis, the incidence of postoperative nausea and vomiting was 37%, and 21%, respectively. Conclusions: A prospective controlled study in children undergoing endoscopic adenoidectomy under general anesthesia showed that dexamethasone (0.15 mg/kg) significantly reduced the incidence of PONV without increasing the risk of postoperative hemorrhage. Dexamethasone is a safe method for the prevention of PONV that may be recommended in pediatric anesthesiology.

Links

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Name: CZECRIN II

Citovat

FRELICH, M., J. DIVAK, V. VODICKA, M. MASAROVA, O. JOR and R. GAL. Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage. MEDICAL SCIENCE MONITOR. MELVILLE: INT SCIENTIFIC INFORMATION, INC, 2018, vol. 24, p. 8430-8438. ISSN 1643-3750. Available from: https://dx.doi.org/10.12659/MSM.911231.

@article{1808051,
   author = {Frelich, M. and Divak, J. and Vodicka, V. and Masarova, M. and Jor, O. and Gal, R.},
   article_location = {MELVILLE},
   doi = {http://dx.doi.org/10.12659/MSM.911231},
   keywords = {Adenoidectomy; Dexamethasone; Postoperative Complications; Postoperative Nausea and Vomiting},
   language = {eng},
   issn = {1643-3750},
   journal = {MEDICAL SCIENCE MONITOR},
   note = {RIV/65269705:_____/18:00069466},
   title = {Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage},
   url = {https://www.medscimonit.com/abstract/index/idArt/911231},
   volume = {24},
   year = {2018}
}

TY  - JOUR
ID  - 1808051
AU  - Frelich, M. - Divak, J. - Vodicka, V. - Masarova, M. - Jor, O. - Gal, R.
PY  - 2018
TI  - Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage
JF  - MEDICAL SCIENCE MONITOR
VL  - 24
SP  - 8430-8438
EP  - 8430-8438
PB  - INT SCIENTIFIC INFORMATION, INC
SN  - 16433750
N1  - RIV/65269705:_____/18:00069466
KW  - Adenoidectomy
KW  - Dexamethasone
KW  - Postoperative Complications
KW  - Postoperative Nausea and Vomiting
UR  - https://www.medscimonit.com/abstract/index/idArt/911231
N2  - Background: Postoperative nausea and vomiting (PONV) is a common complication of pediatric anesthesia, but the overall incidence of PONV in patients undergoing adenoidectomy is unknown. The aim of this controlled study was to compare the effect of dexamethasone administration with placebo to reduce PONV in children undergoing endoscopic adenoidectomy under general anesthesia. Material/Methods: A randomized placebo-controlled study included 118 pediatric patients who underwent elective endoscopic adenoidectomy under general anesthesia. A dexamethasone-treated (0.15 mg/kg) group (Group D) (n=56) and a placebo group (Group C) (n=62) were randomly assigned. The incidence of nausea and vomiting was recorded on the day of surgery. Postoperative nausea was assessed according to illustrated Baxter Animated Retching Faces (BARF) scale. The Face, Legs, Activity, Cry, and Consolability (FLACC) scale (scores between 0-10) was used to assess pain. Follow-up was performed on the 14th postoperative day by a telephone call. Results: Overall prevalence of postoperative nausea was 25% (30/118) and postoperative vomiting was 14% (17/118). In the first 24 hours following surgery, in Group D, the incidence of nausea and vomiting was 13% and 7%, respectively; in Group C, without pharmacological prophylaxis, the incidence of postoperative nausea and vomiting was 37%, and 21%, respectively. Conclusions: A prospective controlled study in children undergoing endoscopic adenoidectomy under general anesthesia showed that dexamethasone (0.15 mg/kg) significantly reduced the incidence of PONV without increasing the risk of postoperative hemorrhage. Dexamethasone is a safe method for the prevention of PONV that may be recommended in pediatric anesthesiology.
ER  -

FRELICH, M., J. DIVAK, V. VODICKA, M. MASAROVA, O. JOR and R. GAL. Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage. \textit{MEDICAL SCIENCE MONITOR}. MELVILLE: INT SCIENTIFIC INFORMATION, INC, 2018, vol.~24, p.~8430-8438. ISSN~1643-3750. Available from: https://dx.doi.org/10.12659/MSM.911231.

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