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@article{1808237,
author = {Bencsikova, B. and Budinska, E. and Selingerová, I. and Pilatova, K. and Fedorova, L. and Greplova, K. and Nenutil, R. and Valík, Dalibor and Obermannová, Radka and Sheard, M.A. and Zdrazilova Dubska, L.},
article_location = {London},
article_number = {687},
doi = {http://dx.doi.org/10.1186/s12885-019-5909-5},
keywords = {Metastatic colorectal cancer; T cell subsets; Regulatory T cells; Antitumor immune response; Anti-VEGF; Primary colorectal carcinoma sidedness},
language = {eng},
issn = {1471-2407},
journal = {BMC Cancer},
note = {RIV/00209805:_____/19:00078214!RIV20-MSM-00209805},
title = {Circulating T cell subsets are associated with clinical outcome of anti-VEGF-based 1st-line treatment of metastatic colorectal cancer patients: a prospective study with focus on primary tumor sidedness},
url = {https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5909-5},
volume = {19},
year = {2019}
}
TY - JOUR
ID - 1808237
AU - Bencsikova, B. - Budinska, E. - Selingerová, I. - Pilatova, K. - Fedorova, L. - Greplova, K. - Nenutil, R. - Valík, Dalibor - Obermannová, Radka - Sheard, M.A. - Zdrazilova Dubska, L.
PY - 2019
TI - Circulating T cell subsets are associated with clinical outcome of anti-VEGF-based 1st-line treatment of metastatic colorectal cancer patients: a prospective study with focus on primary tumor sidedness
JF - BMC Cancer
VL - 19
IS - 687
SP - 1-9
EP - 1-9
PB - BioMed Central
SN - 14712407
N1 - RIV/00209805:_____/19:00078214!RIV20-MSM-00209805
KW - Metastatic colorectal cancer
KW - T cell subsets
KW - Regulatory T cells
KW - Antitumor immune response
KW - Anti-VEGF
KW - Primary colorectal carcinoma sidedness
UR - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5909-5
N2 - BackgroundIn a prospective study with long-term follow-up, we analyzed circulating T cell subsets in patients with metastatic colorectal cancer (mCRC) in the context of primary tumor sidedness, KRAS status, and clinical outcome. Our primary goal was to investigate whether baseline levels of circulating T cell subsets serve as a potential biomarker of clinical outcome of mCRC patients treated with an anti-VEGF-based regimen.MethodsThe study group consisted of 36 patients with colorectal adenocarcinoma who started first-line chemotherapy with bevacizumab for metastatic disease. We quantified T cell subsets including Tregs and CD8(+) T cells in the peripheral blood prior to therapy initiation. Clinical outcome was evaluated as progression-free survival (PFS), overall survival (OS), and objective response rate (ORR).Results1) mCRC patients with KRAS wt tumors had higher proportions of circulating CD8(+) cytotoxic T cells among all T cells but also higher measures of T regulatory (Treg) cells such as absolute count and a higher proportion of Tregs in the CD4(+) subset. 2) A low proportion of circulating Tregs among CD4(+) cells, and a high CD8:Treg ratio at initiation of VEGF-targeting therapy, were associated with favorable clinical outcome. 3) In a subset of patients with primarily right-sided mCRC, superior PFS and OS were observed when the CD8:Treg ratio was high.ConclusionsThe baseline level of circulating immune cells predicts clinical outcome of 1st-line treatment with the anti-VEGF angio/immunomodulatory agent bevacizumab. Circulating immune biomarkers, namely the CD8:Treg ratio, identified patients in the right-sided mCRC subgroup with favorable outcome following treatment with 1st-line anti-VEGF treatment.
ER -
BENCSIKOVA, B., E. BUDINSKA, I. SELINGEROVÁ, K. PILATOVA, L. FEDOROVA, K. GREPLOVA, R. NENUTIL, Dalibor VALÍK, Radka OBERMANNOVÁ, M.A. SHEARD and L. ZDRAZILOVA DUBSKA. Circulating T cell subsets are associated with clinical outcome of anti-VEGF-based 1st-line treatment of metastatic colorectal cancer patients: a prospective study with focus on primary tumor sidedness. \textit{BMC Cancer}. London: BioMed Central, 2019, vol.~19, No~687, p.~1-9. ISSN~1471-2407. Available from: https://dx.doi.org/10.1186/s12885-019-5909-5.
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