Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS
Lung Cancer Clinical Registry

J 2021

Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry

VENCLÍČEK, Ondřej, Jana SKŘIČKOVÁ, Kristián BRAT, Ondrej FISCHER, Libor HAVEL et. al.

Základní údaje

Originální název

Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry

Autoři

VENCLÍČEK, Ondřej (203 Česká republika, garant, domácí), Jana SKŘIČKOVÁ (203 Česká republika, domácí), Kristián BRAT (703 Slovensko, domácí), Ondrej FISCHER (203 Česká republika), Libor HAVEL (203 Česká republika), Michal HRNCIARIK (203 Česká republika), Miloslav MAREL (203 Česká republika), Petr OPALKA (203 Česká republika), Gabriela KRAKOROVA (203 Česká republika), Denisa ROZSIVALOVA (203 Česká republika), Juraj KULTAN (203 Česká republika), Andrea MULLEROVA (203 Česká republika), Lydia ZARNAYOVA (203 Česká republika), Petra SMICKOVA (203 Česká republika), Martina VASAKOVA (203 Česká republika), Zsuzsanna GYORFY (203 Česká republika), Michal JIROUSEK (203 Česká republika), Daniel KREJCI (203 Česká republika), Jana KREJCI (203 Česká republika), Petr ZUNA (203 Česká republika), Martin SVATON (203 Česká republika), Kristyna HRDA (203 Česká republika), Jaroslav DUBA (203 Česká republika), Jana ALAHAKOON (203 Česká republika), Michal SVOBODA (203 Česká republika, domácí) a Jiri SILAR (203 Česká republika)

Vydání

Anticancer Research, Athens, International Institute of Anticancer Research, 2021, 0250-7005

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.435

Kód RIV

RIV/00216224:14110/21:00123236

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.21873/anticanres.15368

UT WoS

000720235500001

Klíčová slova anglicky

Lung cancer; non-smokers; clinical registry; NSCLC; survival; driving mutations

Štítky

14110215, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 12. 2021 12:33, Mgr. Tereza Miškechová

Anotace

V originále

Background/Aim: LUCAS is a clinical lung cancer registry (ClinicalTrials.gov identifier is NCT04228237), prospectively collecting data from newly diagnosed lung cancer patients in seven pneumooncology centers in the Czech Republic, since June 1, 2018. The aim of the study was to assess the stage of the disease at the time of diagnosis, percentage of morphological types, survival, percentage of driving mutations, eligibility for radical surgery, and percentage of patients who undergo radical surgery, in the non-smoking population in comparison with smokers and former smokers. Patients and Methods: The total number of patients in the registry at the time of the analysis was 2,743. Only 2,439 patients with complete records (smoking status, stage, and type of tumor) were included in this study. Results: The analysis indicated that non-smokers are diagnosed at a later stage of the disease but they have a better survival rate than smokers. Fewer smokers with stage III disease who are eligible for radical surgery will undergo surgery compared to non-smokers with the same clinical stage. Driving mutations are more common in non-smokers, even after adjustment for the more frequent occurrence of adenocarcinoma in the group of non-smokers. Conclusion: The data from LUCAS registry are consistent with already known facts, suggesting that the LUCAS registry is a useful clinical tool.

Citovat

VENCLÍČEK, Ondřej, Jana SKŘIČKOVÁ, Kristián BRAT, Ondrej FISCHER, Libor HAVEL, Michal HRNCIARIK, Miloslav MAREL, Petr OPALKA, Gabriela KRAKOROVA, Denisa ROZSIVALOVA, Juraj KULTAN, Andrea MULLEROVA, Lydia ZARNAYOVA, Petra SMICKOVA, Martina VASAKOVA, Zsuzsanna GYORFY, Michal JIROUSEK, Daniel KREJCI, Jana KREJCI, Petr ZUNA, Martin SVATON, Kristyna HRDA, Jaroslav DUBA, Jana ALAHAKOON, Michal SVOBODA a Jiri SILAR. Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry. Anticancer Research. Athens: International Institute of Anticancer Research, 2021, roč. 41, č. 11, s. 5549-5556. ISSN 0250-7005. Dostupné z: https://dx.doi.org/10.21873/anticanres.15368.

@article{1809527,
   author = {Venclíček, Ondřej and Skřičková, Jana and Brat, Kristián and Fischer, Ondrej and Havel, Libor and Hrnciarik, Michal and Marel, Miloslav and Opalka, Petr and Krakorova, Gabriela and Rozsivalova, Denisa and Kultan, Juraj and Mullerova, Andrea and Zarnayova, Lydia and Smickova, Petra and Vasakova, Martina and Gyorfy, Zsuzsanna and Jirousek, Michal and Krejci, Daniel and Krejci, Jana and Zuna, Petr and Svaton, Martin and Hrda, Kristyna and Duba, Jaroslav and Alahakoon, Jana and Svoboda, Michal and Silar, Jiri},
   article_location = {Athens},
   article_number = {11},
   doi = {http://dx.doi.org/10.21873/anticanres.15368},
   keywords = {Lung cancer; non-smokers; clinical registry; NSCLC; survival; driving mutations},
   language = {eng},
   issn = {0250-7005},
   journal = {Anticancer Research},
   title = {Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry},
   url = {https://ar.iiarjournals.org/content/41/11/5549},
   volume = {41},
   year = {2021}
}

TY  - JOUR
ID  - 1809527
AU  - Venclíček, Ondřej - Skřičková, Jana - Brat, Kristián - Fischer, Ondrej - Havel, Libor - Hrnciarik, Michal - Marel, Miloslav - Opalka, Petr - Krakorova, Gabriela - Rozsivalova, Denisa - Kultan, Juraj - Mullerova, Andrea - Zarnayova, Lydia - Smickova, Petra - Vasakova, Martina - Gyorfy, Zsuzsanna - Jirousek, Michal - Krejci, Daniel - Krejci, Jana - Zuna, Petr - Svaton, Martin - Hrda, Kristyna - Duba, Jaroslav - Alahakoon, Jana - Svoboda, Michal - Silar, Jiri
PY  - 2021
TI  - Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry
JF  - Anticancer Research
VL  - 41
IS  - 11
SP  - 5549-5556
EP  - 5549-5556
PB  - International Institute of Anticancer Research
SN  - 02507005
KW  - Lung cancer
KW  - non-smokers
KW  - clinical registry
KW  - NSCLC
KW  - survival
KW  - driving mutations
UR  - https://ar.iiarjournals.org/content/41/11/5549
N2  - Background/Aim: LUCAS is a clinical lung cancer registry (ClinicalTrials.gov identifier is NCT04228237), prospectively collecting data from newly diagnosed lung cancer patients in seven pneumooncology centers in the Czech Republic, since June 1, 2018. The aim of the study was to assess the stage of the disease at the time of diagnosis, percentage of morphological types, survival, percentage of driving mutations, eligibility for radical surgery, and percentage of patients who undergo radical surgery, in the non-smoking population in comparison with smokers and former smokers. Patients and Methods: The total number of patients in the registry at the time of the analysis was 2,743. Only 2,439 patients with complete records (smoking status, stage, and type of tumor) were included in this study. Results: The analysis indicated that non-smokers are diagnosed at a later stage of the disease but they have a better survival rate than smokers. Fewer smokers with stage III disease who are eligible for radical surgery will undergo surgery compared to non-smokers with the same clinical stage. Driving mutations are more common in non-smokers, even after adjustment for the more frequent occurrence of adenocarcinoma in the group of non-smokers. Conclusion: The data from LUCAS registry are consistent with already known facts, suggesting that the LUCAS registry is a useful clinical tool.
ER  -

VENCLÍČEK, Ondřej, Jana SKŘIČKOVÁ, Kristián BRAT, Ondrej FISCHER, Libor HAVEL, Michal HRNCIARIK, Miloslav MAREL, Petr OPALKA, Gabriela KRAKOROVA, Denisa ROZSIVALOVA, Juraj KULTAN, Andrea MULLEROVA, Lydia ZARNAYOVA, Petra SMICKOVA, Martina VASAKOVA, Zsuzsanna GYORFY, Michal JIROUSEK, Daniel KREJCI, Jana KREJCI, Petr ZUNA, Martin SVATON, Kristyna HRDA, Jaroslav DUBA, Jana ALAHAKOON, Michal SVOBODA a Jiri SILAR. Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry. \textit{Anticancer Research}. Athens: International Institute of Anticancer Research, 2021, roč.~41, č.~11, s.~5549-5556. ISSN~0250-7005. Dostupné z: https://dx.doi.org/10.21873/anticanres.15368.

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