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@article{1809821, author = {Singh, A. and Hussain, Mohammad Salman and Jha, R. and Jayraj, A. S. and Klugar, Miloslav and Antony, B.}, article_location = {HOBOKEN}, article_number = {4}, doi = {http://dx.doi.org/10.1111/jebm.12456}, keywords = {hepatocellular carcinoma; meta-analysis; pharmacoepidemiological study; proton pump inhibitors; real-world evidence; systematic review}, language = {eng}, issn = {1756-5383}, journal = {JOURNAL OF EVIDENCE BASED MEDICINE}, title = {Proton pump inhibitor use and the risk of hepatocellular carcinoma: A systematic review of pharmacoepidemiological data}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/jebm.12456}, volume = {14}, year = {2021} }
TY - JOUR ID - 1809821 AU - Singh, A. - Hussain, Mohammad Salman - Jha, R. - Jayraj, A. S. - Klugar, Miloslav - Antony, B. PY - 2021 TI - Proton pump inhibitor use and the risk of hepatocellular carcinoma: A systematic review of pharmacoepidemiological data JF - JOURNAL OF EVIDENCE BASED MEDICINE VL - 14 IS - 4 SP - 278-280 EP - 278-280 PB - WILEY SN - 17565383 KW - hepatocellular carcinoma KW - meta-analysis KW - pharmacoepidemiological study KW - proton pump inhibitors KW - real-world evidence KW - systematic review UR - https://onlinelibrary.wiley.com/doi/epdf/10.1111/jebm.12456 N2 - Proton pump inhibitors (PPIs) were first introduced in the market in the 1980s and are used as an over-the-counter (OTC) drug for acid-related diseases of the gastrointestinal tract. (1) Over the years, both prescription and non-prescription use of PPIs has grown exponentially, and they are now among the most widely used class of drugs globally. (2) PPIs are generally intended for short-term use and are rarely required beyond four to eight weeks; however, in real-world practice, their duration of use often extends beyond recommended guidelines. Hepatocellular carcinoma (HCC), a primary liver cancer, is a heterogeneous disease with multiple variables that differ by geography and presence or absence of prognostic factors such as NAFLD and cirrhosis. Preclinical studies have found PPIs-induced acid suppression to be associated with disease progression in hepatic diseases such as alcoholic liver disease, NAFLD, non-alcoholic steatohepatitis, and liver tumors. Similarly, population-based studies have also found an association of PPIs use with the risk of acute liver injury. (3) Nevertheless, many recent pharmacoepidemiologic studies using real-world databases to evaluate the association between PPIs and the risk of HCC show divergent results. (4-6) Thus, a systematic review was conducted to identify all the published articles and to determine the effect of PPI on the risk of HCC based on real-world data studies. ER -
SINGH, A., Mohammad Salman HUSSAIN, R. JHA, A. S. JAYRAJ, Miloslav KLUGAR a B. ANTONY. Proton pump inhibitor use and the risk of hepatocellular carcinoma: A systematic review of pharmacoepidemiological data. \textit{JOURNAL OF EVIDENCE BASED MEDICINE}. HOBOKEN: WILEY, 2021, roč.~14, č.~4, s.~278-280. ISSN~1756-5383. Dostupné z: https://dx.doi.org/10.1111/jebm.12456.
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