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@article{1812479,
author = {Kunovský, Lumír and Dítě, Petr and Jabandžiev, Petr and Eid, Michal and Poredská, Karolina and Vaculová, Jitka and Sochorová, Dana and Janeček, Pavel and Tesaříková, Pavla and Blaho, Martin and Trna, Jan and Hlavsa, Jan and Kala, Zdeněk},
article_location = {Basel},
article_number = {24},
doi = {http://dx.doi.org/10.3390/jcm10245779},
keywords = {exocrine pancreatic insufficiency; pancreatic enzyme replacement therapy; pancreatic cancer; cystic fibrosis; pancreatic resection; surgery; diabetes; celiac disease; inflammatory bowel disease; microbiome},
language = {eng},
issn = {2077-0383},
journal = {Journal of Clinical Medicine},
title = {Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis},
url = {https://www.mdpi.com/2077-0383/10/24/5779#cite},
volume = {10},
year = {2021}
}
TY - JOUR
ID - 1812479
AU - Kunovský, Lumír - Dítě, Petr - Jabandžiev, Petr - Eid, Michal - Poredská, Karolina - Vaculová, Jitka - Sochorová, Dana - Janeček, Pavel - Tesaříková, Pavla - Blaho, Martin - Trna, Jan - Hlavsa, Jan - Kala, Zdeněk
PY - 2021
TI - Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis
JF - Journal of Clinical Medicine
VL - 10
IS - 24
SP - 1-22
EP - 1-22
PB - MDPI
SN - 20770383
KW - exocrine pancreatic insufficiency
KW - pancreatic enzyme replacement therapy
KW - pancreatic cancer
KW - cystic fibrosis
KW - pancreatic resection
KW - surgery
KW - diabetes
KW - celiac disease
KW - inflammatory bowel disease
KW - microbiome
UR - https://www.mdpi.com/2077-0383/10/24/5779#cite
N2 - Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and malnutrition, results from primary pancreatic disease or is secondary to impaired exocrine pancreatic function. Although chronic pancreatitis is the most common cause of EPI, several additional causes exist. These include pancreatic tumors, pancreatic resection procedures, and cystic fibrosis. Other diseases and conditions, such as diabetes mellitus, celiac disease, inflammatory bowel disease, and advanced patient age, have also been shown to be associated with EPI, but the exact etiology of EPI has not been clearly elucidated in these cases. The causes of EPI can be divided into loss of pancreatic parenchyma, inhibition or inactivation of pancreatic secretion, and postcibal pancreatic asynchrony. Pancreatic enzyme replacement therapy (PERT) is indicated for the conditions described above presenting with clinically clear steatorrhea, weight loss, or symptoms related to maldigestion and malabsorption. This review summarizes the current literature concerning those etiologies of EPI less common than chronic pancreatitis, the pathophysiology of the mechanisms of EPI associated with each diagnosis, and treatment recommendations.
ER -
KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Michal EID, Karolina POREDSKÁ, Jitka VACULOVÁ, Dana SOCHOROVÁ, Pavel JANEČEK, Pavla TESAŘÍKOVÁ, Martin BLAHO, Jan TRNA, Jan HLAVSA a Zdeněk KALA. Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2021, roč.~10, č.~24, s.~1-22. ISSN~2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm10245779.
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