CT Evaluated Sarcopenia Signals: Shorter Survival for Small
Cell Lung Cancer Patients

J 2021

CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients

PEKAŘOVÁ, Anna, Matej PEKAŘ, Daniel DANIŠ a Zuzana NOVÁKOVÁ

Základní údaje

Originální název

CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients

Autoři

PEKAŘOVÁ, Anna (203 Česká republika, domácí), Matej PEKAŘ (703 Slovensko, garant, domácí), Daniel DANIŠ (703 Slovensko) a Zuzana NOVÁKOVÁ (203 Česká republika, domácí)

Vydání

Physiological Research, Praha, Institute of Physiology, Academy of Sci, 2021, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.139

Kód RIV

RIV/00216224:14110/21:00123367

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.33549/physiolres.934816

UT WoS

000755158200012

Klíčová slova anglicky

small cell lung cancer; survival; sarcopenia; psoas muscle density; abdominal muscle area

Štítky

14110515, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 5. 2022 12:42, Mgr. Tereza Miškechová

Anotace

V originále

Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from small cell lung cancer (SCLC), however, a universal indicator of sarcopenia usable in clinical practice is still missing. A novel indicator for describing the severity of cancer could be helpful in tailoring the anti-tumor therapy. The aim of this study was to evaluate the computed tomography (CT) scans of total muscle area and radiation attenuation in patients suffering from small cell lung cancer. We used staging CT scans performed at the time of diagnosis to measure total muscle area (TMA) and average psoas density (PD) at level of the 3rd lumbar vertebra. TMA and PD were statistically evaluated in association with overall survival and disease staging. We used Mann-Whitney test and Spearman ' s correlation coefficient for statistical testing and p-value under 0.05 was considered statistically significant. Retrospectively we examined 47 patients suffering from SCLC (mean age 65.05 +/- 7.3 years, BMI 23.97 +/- 4.4 kg/m(2) , BSA 1.77 +/- 0.2 m(2) , 30-day mortality was 4.3 % with 10 months median survival). As sarcopenia was pointed TMA under 55 and 39 cm(2)/m(2) for men and women respectively. The sarcopenic patients had significantly shorter median survival (7 vs. 11 months, p=0.05). We observed a significant relationship between survival and performance status (Spearman ' s correlation, R=-0.39, p=0.05). The patients were divided into two groups according to the extensive (ED, n=34) or limited (LD, n=13) form of the disease. We observed significant difference in PD (42.49 +/- 6.1 vs. 47.67 +/- 4.5 HU, p=0.006) between ED vs. LD groups.

Návaznosti

MUNI/A/1246/2020, interní kód MU

Název: Kardiovaskulární systém: od iontového kanálu k celotělovému modelu (Akronym: KAVASYKAMO)

Investor: Masarykova univerzita, Kardiovaskulární systém: od iontového kanálu k celotělovému modelu

Citovat

PEKAŘOVÁ, Anna, Matej PEKAŘ, Daniel DANIŠ a Zuzana NOVÁKOVÁ. CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients. Physiological Research. Praha: Institute of Physiology, Academy of Sci, 2021, roč. 70, (Suppl. 3), s. "S381"-"S386", 6 s. ISSN 0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934816.

@article{1813265,
   author = {Pekařová, Anna and Pekař, Matej and Daniš, Daniel and Nováková, Zuzana},
   article_location = {Praha},
   article_number = {(Suppl. 3)},
   doi = {http://dx.doi.org/10.33549/physiolres.934816},
   keywords = {small cell lung cancer; survival; sarcopenia; psoas muscle density; abdominal muscle area},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients},
   url = {https://doi.org/10.33549/physiolres.934816},
   volume = {70},
   year = {2021}
}

TY  - JOUR
ID  - 1813265
AU  - Pekařová, Anna - Pekař, Matej - Daniš, Daniel - Nováková, Zuzana
PY  - 2021
TI  - CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients
JF  - Physiological Research
VL  - 70
IS  - (Suppl. 3)
SP  - "S381"-"S386"
EP  - "S381"-"S386"
PB  - Institute of Physiology, Academy of Sci
SN  - 08628408
KW  - small cell lung cancer
KW  - survival
KW  - sarcopenia
KW  - psoas muscle density
KW  - abdominal muscle area
UR  - https://doi.org/10.33549/physiolres.934816
N2  - Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from small cell lung cancer (SCLC), however, a universal indicator of sarcopenia usable in clinical practice is still missing. A novel indicator for describing the severity of cancer could be helpful in tailoring the anti-tumor therapy. The aim of this study was to evaluate the computed tomography (CT) scans of total muscle area and radiation attenuation in patients suffering from small cell lung cancer. We used staging CT scans performed at the time of diagnosis to measure total muscle area (TMA) and average psoas density (PD) at level of the 3rd lumbar vertebra. TMA and PD were statistically evaluated in association with overall survival and disease staging. We used Mann-Whitney test and Spearman ' s correlation coefficient for statistical testing and p-value under 0.05 was considered statistically significant. Retrospectively we examined 47 patients suffering from SCLC (mean age 65.05 +/- 7.3 years, BMI 23.97 +/- 4.4 kg/m(2) , BSA 1.77 +/- 0.2 m(2) , 30-day mortality was 4.3 % with 10 months median survival). As sarcopenia was pointed TMA under 55 and 39 cm(2)/m(2) for men and women respectively. The sarcopenic patients had significantly shorter median survival (7 vs. 11 months, p=0.05). We observed a significant relationship between survival and performance status (Spearman ' s correlation, R=-0.39, p=0.05). The patients were divided into two groups according to the extensive (ED, n=34) or limited (LD, n=13) form of the disease. We observed significant difference in PD (42.49 +/- 6.1 vs. 47.67 +/- 4.5 HU, p=0.006) between ED vs. LD groups.
ER  -

PEKAŘOVÁ, Anna, Matej PEKAŘ, Daniel DANIŠ a Zuzana NOVÁKOVÁ. CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients. \textit{Physiological Research}. Praha: Institute of Physiology, Academy of Sci, 2021, roč.~70, (Suppl. 3), s.~''S381''-''S386'', 6 s. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934816.

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