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@proceedings{1814117,
author = {Smrčka, Martin and Večeřa, Marek and Radová, Lenka and Sidorová, Simona and Siegl, František and Jančálek, Radim and Hermanová, Markéta and Křen, Leoš and Šána, Jiří and Slabý, Ondřej},
booktitle = {Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti},
keywords = {brain metastases; microRNA},
language = {eng},
title = {Global profiling of microRNA expression in brain metastases},
year = {2021}
}
TY - CONF
ID - 1814117
AU - Smrčka, Martin - Večeřa, Marek - Radová, Lenka - Sidorová, Simona - Siegl, František - Jančálek, Radim - Hermanová, Markéta - Křen, Leoš - Šána, Jiří - Slabý, Ondřej
PY - 2021
TI - Global profiling of microRNA expression in brain metastases
KW - brain metastases
KW - microRNA
N2 - Brain metastases (BM) are the most common intracranial tumors occurring in 20-40% of adult cancer patients. BM have long received little attention and, in general, symptomatic palliative care has been indicated without attempting to significantly prolong overall survival (OS). The current approach to BM treatment is changing as the incidence increases over time because of more effective treatment of primary tumors prolonging OS, as well as improved imaging to detect smaller asymptomatic BM. Although the survival of patients with BM is generally unfavorable, the prognosis individually varies significantly. Therefore, it would be useful to strengthen prognostic tools with new high-performance molecular markers. Particularly promising are microRNAs (miRNAs), non-coding RNAs with the length of 18-25 nt, which post-transcriptionally regulate gene expression by silencing mRNA targets. They are stable and thus suitable for sequencing and retrospective analyses in FFPE tissues. Although dysregulated expression (DE) and diagnostic potential of miRNAs have been described in tumors, including BM, there is only a handful of studies describing global miRNA expression profiling in BM and their association with OS.
ER -
SMRČKA, Martin, Marek VEČEŘA, Lenka RADOVÁ, Simona SIDOROVÁ, František SIEGL, Radim JANČÁLEK, Markéta HERMANOVÁ, Leoš KŘEN, Jiří ŠÁNA a Ondřej SLABÝ. Global profiling of microRNA expression in brain metastases. In \textit{Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti}. 2021.
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