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@proceedings{1814118,
author = {Siegl, František and Večeřa, Marek and Trachtová, Karolína and Al Tukmachi, Dagmar and Bušek, Petr and Fadrus, Pavel and Smrčka, Martin and Slabý, Ondřej and Šána, Jiří},
booktitle = {Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti},
keywords = {glioblastoma; PIWI-interacting RNAs},
language = {eng},
title = {Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation?},
year = {2021}
}
TY - CONF
ID - 1814118
AU - Siegl, František - Večeřa, Marek - Trachtová, Karolína - Al Tukmachi, Dagmar - Bušek, Petr - Fadrus, Pavel - Smrčka, Martin - Slabý, Ondřej - Šána, Jiří
PY - 2021
TI - Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation?
KW - glioblastoma
KW - PIWI-interacting RNAs
N2 - Glioblastoma (GBM) is the most common malignant brain tumor of astrocytic origin. Despite the radical therapy, relapse is a common and relatively early event, with the major mechanism possibly being the presence of glioblastoma stem cells (GSC), able to withstand the therapy and to establish new GBM deposits. PIWI-interacting RNAs (piRNA) may have a key role in GSC biology, which are physiologically responsible for the genome stability maintenance in germ and stem cells. Nevertheless, their dysregulation was observed in cancers, including GBM. Identification of GSC-specific piRNA molecules could lead to distinguishing GSC from their differentiated counterparts (non-GSC), enabling their therapeutic targeting.
ER -
SIEGL, František, Marek VEČEŘA, Karolína TRACHTOVÁ, Dagmar AL TUKMACHI, Petr BUŠEK, Pavel FADRUS, Martin SMRČKA, Ondřej SLABÝ a Jiří ŠÁNA. Study of PIWI-Interacting RNAs in the pathology of glioblastoma: a new level of glioblastoma stem cell regulation? In \textit{Sborník abstrakt – VII. Sjezd Ukrajinské neurochirurgické společnosti}. 2021.
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