Epileptogenic zone detection in MRI negative epilepsy using
adaptive thresholding of arterial spin labeling data

J 2021

Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data

GAJDOŠ, Martin, Pavel ŘÍHA, Martin KOJAN, Irena DOLEŽALOVÁ, H.J.M.M. MUTSAERTS et. al.

Základní údaje

Originální název

Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data

Autoři

GAJDOŠ, Martin (203 Česká republika, domácí), Pavel ŘÍHA (203 Česká republika, domácí), Martin KOJAN (703 Slovensko, domácí), Irena DOLEŽALOVÁ (203 Česká republika, domácí), H.J.M.M. MUTSAERTS, J. PETR a Ivan REKTOR (203 Česká republika, garant, domácí)

Vydání

Nature Scientific Reports, London, NATURE RESEARCH, 2021, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.996

Kód RIV

RIV/00216224:14740/21:00120198

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1038/s41598-021-89774-4

UT WoS

000659135700033

Klíčová slova anglicky

TEMPORAL-LOBE EPILEPSY; CONSENSUS CLASSIFICATION; TASK-FORCE; PERFUSION; HYPOPERFUSION

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 10. 2024 09:50, Mgr. Adéla Pešková

Anotace

V originále

Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion MRI can help localize the epileptogenic zone (EZ). To that end, we developed an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images. We demonstrated three thresholding criteria (termed minimal product criterion, minimal distance criterion, and elbow criterion) on 29 patients with MRI-negative epilepsy (age 32.98 +/- 10.4 years). The minimal product criterion showed optimal results in terms of positive predictive value (mean 0.12 in postoperative group and 0.22 in preoperative group) and true positive rate (mean 0.71 in postoperative group and 1.82 in preoperative group). Additionally, we found high accuracy in determining the EZ side (mean 0.86 in postoperative group and 0.73 in preoperative group out of 1.00). ASL can be easily incorporated into the standard presurgical MR protocol, and it provides an additional benefit in EZ localization.

Návaznosti

LM2018129, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

NV17-32292A, projekt VaV

Název: Detekce léze u nelezionální epilepsie s využitím multimodálního zobrazování

Citovat

GAJDOŠ, Martin, Pavel ŘÍHA, Martin KOJAN, Irena DOLEŽALOVÁ, H.J.M.M. MUTSAERTS, J. PETR a Ivan REKTOR. Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data. Nature Scientific Reports. London: NATURE RESEARCH, 2021, roč. 11, č. 1, s. 10904-10909. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-021-89774-4.

@article{1816718,
   author = {Gajdoš, Martin and Říha, Pavel and Kojan, Martin and Doležalová, Irena and Mutsaerts, H.J.M.M. and Petr, J. and Rektor, Ivan},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-021-89774-4},
   keywords = {TEMPORAL-LOBE EPILEPSY; CONSENSUS CLASSIFICATION; TASK-FORCE; PERFUSION; HYPOPERFUSION},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data},
   url = {https://www.nature.com/articles/s41598-021-89774-4.pdf},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1816718
AU  - Gajdoš, Martin - Říha, Pavel - Kojan, Martin - Doležalová, Irena - Mutsaerts, H.J.M.M. - Petr, J. - Rektor, Ivan
PY  - 2021
TI  - Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
JF  - Nature Scientific Reports
VL  - 11
IS  - 1
SP  - 10904
EP  - 10904
PB  - NATURE RESEARCH
SN  - 20452322
KW  - TEMPORAL-LOBE EPILEPSY
KW  - CONSENSUS CLASSIFICATION
KW  - TASK-FORCE
KW  - PERFUSION
KW  - HYPOPERFUSION
UR  - https://www.nature.com/articles/s41598-021-89774-4.pdf
N2  - Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion MRI can help localize the epileptogenic zone (EZ). To that end, we developed an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images. We demonstrated three thresholding criteria (termed minimal product criterion, minimal distance criterion, and elbow criterion) on 29 patients with MRI-negative epilepsy (age 32.98 +/- 10.4 years). The minimal product criterion showed optimal results in terms of positive predictive value (mean 0.12 in postoperative group and 0.22 in preoperative group) and true positive rate (mean 0.71 in postoperative group and 1.82 in preoperative group). Additionally, we found high accuracy in determining the EZ side (mean 0.86 in postoperative group and 0.73 in preoperative group out of 1.00). ASL can be easily incorporated into the standard presurgical MR protocol, and it provides an additional benefit in EZ localization.
ER  -

GAJDOŠ, Martin, Pavel ŘÍHA, Martin KOJAN, Irena DOLEŽALOVÁ, H.J.M.M. MUTSAERTS, J. PETR a Ivan REKTOR. Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2021, roč.~11, č.~1, s.~10904-10909. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-021-89774-4.

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