Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus

DEUTSCHOVÁ, Barbora, P. KLIMES, Z. JORDAN, P. JURAK, L. EROSS, Martin LAMOŠ, J. HALAMEK, Pavel DANIEL, Ivan REKTOR and D. FABO. Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus. Epilepsia. Hoboken: Wiley-Blackwell, 2021, vol. 62, No 5, p. "E70"-"E75", 6 pp. ISSN 0013-9580. Available from: https://dx.doi.org/10.1111/epi.16883.

Basic information

• Original name: Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus
• Authors: DEUTSCHOVÁ, Barbora (203 Czech Republic, belonging to the institution), P. KLIMES, Z. JORDAN, P. JURAK, L. EROSS, Martin LAMOŠ (203 Czech Republic, belonging to the institution), J. HALAMEK, Pavel DANIEL (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution) and D. FABO.
• Edition: Epilepsia, Hoboken, Wiley-Blackwell, 2021, 0013-9580.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30210 Clinical neurology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 6.740
• RIV identification code: RIV/00216224:14740/21:00119502
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1111/epi.16883
• UT WoS: 000631593800001
• Keywords in English: anterior thalamic nucleus; deep brain stimulation; oscillations; prediction
• Tags: 14110127, podil, rivok
• Tags: International impact, Reviewed

Abstract

We hypothesized that local/regional properties of stimulated structure/circuitry contribute to the effect of deep brain stimulation (DBS). We analyzed intracerebral electroencephalographic (EEG) recordings from externalized DBS electrodes targeted bilaterally in the anterior nuclei of the thalamus (ANT) in 12 patients (six responders, six nonresponders) with more than 1 year of follow-up care. In the bipolar local field potentials of the EEG, spectral power (PW) and power spectral entropy (PSE) were calculated in the passbands 1-4, 4-8, 8-12, 12-20, 20-45, 65-80, 80-200 and 200-500 Hz. The most significant differences between responders and nonresponders were observed in the BRIDGE area (bipolar recordings with one contact within the ANT and the second contact in adjacent tissue). In responders, PW was significantly decreased in the frequency bands of 65-80, 80-200, and 200-500 Hz (p < .05); PSE was significantly increased in all frequency bands (p < .05) except for 200-500 Hz (p = .06). The local EEG characteristics of ANT recorded after implantation may play a significant role in DBS response prediction.

Links

• GA21-25953S, research and development project: Name: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Acronym: DBS3D)

Investor: Czech Science Foundation, Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective