J 2022

Post-recurrence survival in patients with cervical cancer

CIBULA, David, Lukáš DOSTÁLEK, Jiří JARKOVSKÝ, Constantijne H MOM, Aldo LOPEZ et. al.

Základní údaje

Originální název

Post-recurrence survival in patients with cervical cancer

Autoři

CIBULA, David (203 Česká republika, garant), Lukáš DOSTÁLEK (203 Česká republika), Jiří JARKOVSKÝ (203 Česká republika, domácí), Constantijne H MOM, Aldo LOPEZ, Henrik FALCONER, Giovanni SCAMBIA, Ali AYHAN, Sarah H KIM, David Isla ORTIZ, Jaroslav KLAT, Andreas OBERMAIR, Giampaolo Di MARTINO, Rene PAREJA, Ranjit MANCHANDA, Jan KOSŤUN, Ricardo dos REIS, Mehmet Mutlu MEYDANLI, Diego ODETTO, Rene LAKY, Ignacio ZAPARDIEL, Vít WEINBERGER (203 Česká republika, domácí), Klára BENEŠOVÁ (203 Česká republika, domácí), Martina BORČINOVÁ (203 Česká republika), Fernando CARDENAS, Emelie WALLIN, Luigi Pedone ANCHORA, Huseyin AKILLI, Nadeem R ABU-RUSTUM, Salim Abraham BARQUET-MUÑOZ, Veronika JAVŮRKOVÁ (203 Česká republika), Daniela FISCHEROVÁ (203 Česká republika) a Luc R C W van LONKHUIJZEN

Vydání

Gynecologic Oncology, San Diego, Elsevier, 2022, 0090-8258

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 4.700

Kód RIV

RIV/00216224:14110/22:00125157

Organizační jednotka

Lékařská fakulta

UT WoS

000789325700017

Klíčová slova anglicky

Early-stage cervical cancer; Recurrence; Post-recurrence disease-specific survival; Prognosis; Multivariable model; Risk profile

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 28. 6. 2022 14:09, Mgr. Tereza Miškechová

Anotace

V originále

Background Up to 26% of patients with early-stage cervical cancer experience relapse after primary surgery. However, little is known about which factors influence prognosis following disease recurrence. Therefore, our aims were to determine post-recurrence disease-specific survival (PR-DSS) and to identify respective prognostic factors for PR-DSS. Methods Data from 528 patients with early-stage cervical cancer who relapsed after primary surgery performed between 2007 and 2016 were obtained from the SCANN study (Surveillance in Cervical CANcer). Factors related to the primary disease and recurrence were combined in a multivariable Cox proportional hazards model to predict PR-DSS. Results The 5-year PR-DSS was 39.1% (95% confidence interval [CI] 22.7%–44.5%), median disease-free interval between primary surgery and recurrence (DFI1) was 1.5 years, and median survival after recurrence was 2.5 years. Six significant variables were identified in the multivariable analysis and were used to construct the prognostic model. Two were related to primary treatment (largest tumour size and lymphovascular space invasion) and four to recurrence (DFI1, age at recurrence, presence of symptoms, and recurrence type). The C-statistic after 10-fold cross-validation of prognostic model reached 0.701 (95% CI 0.675–0.727). Three risk-groups with significantly differing prognoses were identified, with 5-year PR-DSS rates of 81.8%, 44.6%, and 12.7%. Conclusions We developed the robust model of PR-DSS to stratify patients with relapsed cervical cancer according to risk profiles using six routinely recorded prognostic markers. The model can be utilised in clinical practice to aid decision-making on the strategy of recurrence management, and to better inform the patients.