Bidirectional Association Between Sleep and Brain Atrophy in Aging

@article{1821821,
   author = {Kokošová, Viktória and Filip, Pavel and Kec, David and Baláž, Marek},
   article_location = {Lausanne},
   article_number = {December 2021},
   doi = {http://dx.doi.org/10.3389/fnagi.2021.726662},
   keywords = {brain aging; sleep; neuroimaging; structural brain integrity; functional brain integrity},
   language = {eng},
   issn = {1663-4365},
   journal = {Frontiers in Aging Neuroscience},
   title = {Bidirectional Association Between Sleep and Brain Atrophy in Aging},
   url = {https://www.frontiersin.org/article/10.3389/fnagi.2021.726662},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1821821
AU  - Kokošová, Viktória - Filip, Pavel - Kec, David - Baláž, Marek
PY  - 2021
TI  - Bidirectional Association Between Sleep and Brain Atrophy in Aging
JF  - Frontiers in Aging Neuroscience
VL  - 13
IS  - December 2021
SP  - 1-7
EP  - 1-7
PB  - Frontiers
SN  - 16634365
KW  - brain aging
KW  - sleep
KW  - neuroimaging
KW  - structural brain integrity
KW  - functional brain integrity
UR  - https://www.frontiersin.org/article/10.3389/fnagi.2021.726662
N2  - Human brain aging is characterized by the gradual deterioration of its function and structure, affected by the interplay of a multitude of causal factors. The sleep, a periodically repeating state of reversible unconsciousness characterized by distinct electrical brain activity, is crucial for maintaining brain homeostasis. Indeed, insufficient sleep was associated with accelerated brain atrophy and impaired brain functional connectivity. Concurrently, alteration of sleep-related transient electrical events in senescence was correlated with structural and functional deterioration of brain regions responsible for their generation, implying the interconnectedness of sleep and brain structure. This review discusses currently available data on the link between human brain aging and sleep derived from various neuroimaging and neurophysiological methods. We advocate the notion of a mutual relationship between the sleep structure and age-related alterations of functional and structural brain integrity, pointing out the position of high-quality sleep as a potent preventive factor of early brain aging and neurodegeneration. However, further studies are needed to reveal the causality of the relationship between sleep and brain aging.
ER  - 

KOKOŠOVÁ, Viktória, Pavel FILIP, David KEC a Marek BALÁŽ. Bidirectional Association Between Sleep and Brain Atrophy in Aging. \textit{Frontiers in Aging Neuroscience}. Lausanne: Frontiers, 2021, roč.~13, December 2021, s.~1-7. ISSN~1663-4365. Dostupné z: https://dx.doi.org/10.3389/fnagi.2021.726662.